Title:
ANTIBODY USED TO TREAT CORONAVIRUS INFECTION
Document Type and Number:
WIPO Patent Application WO/2023/199943
Kind Code:
A1
Abstract:
The present invention provides an antibody that binds to an extracellular domain of TMPRSS2, said antibody being capable of inhibiting the infection of cells by a betacoronavirus. Also provided are an antigen-binding fragment thereof, and a composition comprising the antibody or the antigen-binding fragment.
Inventors:
SAITO TAKASHI (JP)
HARADA MICHISHIGE (JP)
SHIROUZU MIKAKO (JP)
MATSUMOTO TAKEHISA (JP)
IDEI AKIKO (JP)
INOUE JUN-ICHIRO (JP)
YAMAMOTO MIZUKI (JP)
GOHDA JIN (JP)
KAWAGUCHI YASUSHI (JP)
ITO YASUSHI (JP)
ISHIGAKI HIROHITO (JP)
NAKAYAMA MISAKO (JP)
KITAGAWA YOSHINORI (JP)
HARADA MICHISHIGE (JP)
SHIROUZU MIKAKO (JP)
MATSUMOTO TAKEHISA (JP)
IDEI AKIKO (JP)
INOUE JUN-ICHIRO (JP)
YAMAMOTO MIZUKI (JP)
GOHDA JIN (JP)
KAWAGUCHI YASUSHI (JP)
ITO YASUSHI (JP)
ISHIGAKI HIROHITO (JP)
NAKAYAMA MISAKO (JP)
KITAGAWA YOSHINORI (JP)
Application Number:
PCT/JP2023/014855
Publication Date:
October 19, 2023
Filing Date:
April 12, 2023
Export Citation:
Assignee:
RIKEN (JP)
UNIV TOKYO (JP)
NATIONAL UNIV CORPORATION SHIGA UNIV OF MEDICAL SCIENCE (JP)
UNIV TOKYO (JP)
NATIONAL UNIV CORPORATION SHIGA UNIV OF MEDICAL SCIENCE (JP)
International Classes:
A61K39/395; C07K16/40; A61P31/14; C12N15/13; C12N15/57; C12P21/08
Domestic Patent References:
| WO2021163076A1 | 2021-08-19 | |||
| WO2021211406A1 | 2021-10-21 | |||
| WO2019147831A1 | 2019-08-01 | |||
| WO2021211416A1 | 2021-10-21 |
Foreign References:
| CN116003611A | 2023-04-25 |
Other References:
HARADA, M. ET AL.: "WS28-09-P Establishment of anti-TMPRSS2 mAbs that potently inhibit infection of any variants of SARS-CoV-2", PROCEEDINGS OF THE JAPANESE SOCIETY FOR IMMUNOLOGY, NIHON MEN'EKI GAKKAI // JAPANESE SOCIETY FOR IMMUNOLOGY (JSI), JP, vol. 51, 7 December 2022 (2022-12-07) - 9 December 2022 (2022-12-09), JP , pages WS28 - 09, XP009550303, ISSN: 0919-1984
TOMITA YURIKO, MATSUYAMA SHUTOKU, FUKUHARA HIDEO, MAENAKA KATSUMI, KATAOKA HIROAKI, HASHIGUCHI TAKAO, TAKEDA MAKOTO: "The Physiological TMPRSS2 Inhibitor HAI-2 Alleviates SARS-CoV-2 Infection", JOURNAL OF VIROLOGY, THE AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 95, no. 12, 24 May 2021 (2021-05-24), US , XP093057300, ISSN: 0022-538X, DOI: 10.1128/JVI.00434-21
TOMITA YURIKO, MATSUYAMA SHUTOKU, FUKUHARA HIDEO, MAENAKA KATSUMI, KATAOKA HIROAKI, HASHIGUCHI TAKAO, TAKEDA MAKOTO: "The Physiological TMPRSS2 Inhibitor HAI-2 Alleviates SARS-CoV-2 Infection", JOURNAL OF VIROLOGY, THE AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 95, no. 12, 24 May 2021 (2021-05-24), US , XP093057300, ISSN: 0022-538X, DOI: 10.1128/JVI.00434-21
Attorney, Agent or Firm:
MORITA Yutaka (JP)
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