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Title:
ANTICOAGULANT ARTIFICIAL HEART VALVE MATERIAL, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/083758
Kind Code:
A1
Abstract:
Disclosed are an anticoagulant artificial heart valve material, a preparation method therefor and use thereof, which belong to the technical field of biomedical materials. The anticoagulant artificial heart valve material comprises a biological heart valve material, a fluoride super-lubricating anticoagulant coating chemically combined with the biological heart valve material, and a lubricant maintained in the fluoride super-lubricating anticoagulant coating. The fluoride super-lubricating anticoagulant coating is formed by chemically combining a trichlorosilane fluoride with the biological heart valve material by means of chemical vapor deposition or liquid phase deposition, or formed by chemically combining a double-bond fluoride with the biological heart valve material. Constructing the fluoride super-lubricating anticoagulant coating on the surface of the biological heart valve material can significantly reduce platelet adhesion and whole blood adhesion, and improve the anticoagulant performance of the material, thereby effectively overcoming the thrombopoiesis of biological valves. The preparation method for the artificial heart valve material is simple, requires only simple solution soaking or vapor deposition, has less damage to the biological heart valve material, introduces less additional chemical reagents or has less residual chemical reagents, and is beneficial for maintaining good biocompatibility of the material.

Inventors:
WANG YUNBING (CN)
LEI YANG (CN)
YANG LI (CN)
Application Number:
PCT/CN2021/125823
Publication Date:
April 28, 2022
Filing Date:
October 22, 2021
Export Citation:
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Assignee:
JILIN VENUS HAOYUE MEDICAL LTD (CN)
International Classes:
A61L27/36; A61L27/28; A61L27/50; A61L33/00; A61L33/04
Domestic Patent References:
WO2015189716A12015-12-17
Foreign References:
CN112220970A2021-01-15
CN111420120A2020-07-17
CN110124106A2019-08-16
US20170128200A12017-05-11
CN109517204A2019-03-26
RU2374843C12009-12-10
Attorney, Agent or Firm:
SHINY INTELLECTUAL PROPERTY FIRM (CN)
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