ANTICOAGULATION AND ANTICALCIFICATION ARTIFICIAL HEART VALVE MATERIAL, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF

Title:

ANTICOAGULATION AND ANTICALCIFICATION ARTIFICIAL HEART VALVE MATERIAL, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF

Document Type and Number:

WIPO Patent Application WO/2022/083759

Kind Code:

A1

Abstract:

The present invention relates to the technical field of biomedical materials. Disclosed are an anticoagulation and anticalcification artificial heart valve material, a preparation method therefor, and an application thereof. The anticoagulation and anticalcification artificial heart valve material comprises: a biological heart valve material, a fluoride superlubricant anticoagulant coating formed by an amino fluoride or epoxy fluoride modifying the biological heart valve material, and a lubricant kept in the fluoride superlubricant anticoagulant coating. Constructing a fluoride superlubricant anticoagulant coating on the surface of the biological heart valve material can significantly reduce platelet adhesion and whole blood adhesion, greatly improve anticoagulation performance of the material, effectively overcome biological valve thrombogenicity, and improve anticalcification performance of the material. The preparation method for the artificial heart valve material is simple, requires only simple solution immersion or vapor deposition, and brings little damage to the biological heart valve material, and there are few additionally introduced or residual chemical reagents, facilitating maintaining good biocompatibility of the material.

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Inventors:

LEI YANG (CN)
WANG YUNBING (CN)
YANG LI (CN)

Application Number:

PCT/CN2021/125826

Publication Date:

April 28, 2022

Filing Date:

October 22, 2021

Export Citation:

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Assignee:

JILIN VENUS HAOYUE MEDICAL LTD (CN)

International Classes:

A61L27/28; A61L27/36; A61L27/50; A61L33/00; A61L33/04

Domestic Patent References:

WO2015189716A1

2015-12-17

Foreign References:

CN112263715A	2021-01-26
CN111420120A	2020-07-17
CN110025403A	2019-07-19
CN110124106A	2019-08-16
US20170128200A1	2017-05-11
RU2374843C1	2009-12-10

Attorney, Agent or Firm:

SHINY INTELLECTUAL PROPERTY FIRM (CN)

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