Title:
ANTICOAGULANT INTRAVASCULAR STENT COVER FILM AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2022/028395
Kind Code:
A1
Abstract:
Disclosed are an anticoagulant intravascular stent cover film and a preparation method therefor. Silkworm silk is divided into two groups, wherein one of the groups is twisted and combined to obtain a silk thread group, and the other group is a monofilament group; both groups are then boiled with deionized water for degumming; the silk thread group is braided into a tubular structure by using a braiding machine, while the silk of the monofilament group is dissolved in a lithium bromide neutral salt solution to prepare a dissolved silk fibroin solution, the dissolved silk fibroin solution is then poured into a dialysis bag, and the dialysis bag is placed in a container containing deionized water for continuous dialysis to obtain a purified silkworm silk fibroin aqueous solution; the silk fibroin aqueous solution is then concentrated by means of a rotary evaporator; an appropriate amount of a cross-linking agent is added to the silk fibroin aqueous solution for a reaction, and the solution is then coated or spin-coated on the tubular structure; and after air drying with hot air in a rotary manner, same is further spin-coated with hirudin and then air-dried in a rotary manner at room temperature to obtain the anticoagulant intravascular stent cover film. The cover film has excellent biomechanical properties and a long-lasting anticoagulant activity.
Inventors:
WANG JIANNAN (CN)
DAI MENGNAN (CN)
SONG GUANGZHOU (CN)
YI HONGGEN (CN)
DAI MENGNAN (CN)
SONG GUANGZHOU (CN)
YI HONGGEN (CN)
Application Number:
PCT/CN2021/110227
Publication Date:
February 10, 2022
Filing Date:
August 03, 2021
Export Citation:
Assignee:
UNIV SOOCHOW (CN)
International Classes:
A61L31/10; A61L27/34; A61L27/54; A61L27/58; A61L31/14; A61L31/16; A61L33/12; C07K14/435
Foreign References:
| CN112043878A | 2020-12-08 | |||
| CN102343113A | 2012-02-08 | |||
| CN102274089A | 2011-12-14 | |||
| CN106730052A | 2017-05-31 | |||
| CN106902398A | 2017-06-30 | |||
| CN106693082A | 2017-05-24 | |||
| CN103285431A | 2013-09-11 | |||
| CN110075309A | 2019-08-02 | |||
| JP2008073408A | 2008-04-03 |
Other References:
WEI YALI: "Preparation and Hirudin Modification of Silk Fibroin Tubular Scaffold", CHINESE SELECTED DOCTORAL DISSERTATIONS AND MASTER'S THESES DATABASES ( ENGINEERING SCIENCE & TECHNOLOGY I)-SUZHOU UNIVERSITY, 1 March 2014 (2014-03-01), XP055895124, [retrieved on 20220224]
ZHENG ZHONGHOU: "Preparation and Properties of Regenerated Silk Fibroin Materials", CHINESE SELECTED DOCTORAL DISSERTATIONS AND MASTER'S THESES DATABASES (MASTER), ENGINEERING SCIENCE & TECHNOLOGY I) - SUZHOU UNIVERSITY, 1 May 2007 (2007-05-01), XP055895191
WANG QIONGYU: "Preparation and Characterization of Hirudin Anticoagulant Modified Silk Fibroin Materials", CHINA MASTER’S THESES DATABASE, MEDICINE & PUBLIC HEALTH - SUZHOU UNIVERSITY, 1 May 2017 (2017-05-01), XP055895195
ZHENG ZHONGHOU: "Preparation and Properties of Regenerated Silk Fibroin Materials", CHINESE SELECTED DOCTORAL DISSERTATIONS AND MASTER'S THESES DATABASES (MASTER), ENGINEERING SCIENCE & TECHNOLOGY I) - SUZHOU UNIVERSITY, 1 May 2007 (2007-05-01), XP055895191
WANG QIONGYU: "Preparation and Characterization of Hirudin Anticoagulant Modified Silk Fibroin Materials", CHINA MASTER’S THESES DATABASE, MEDICINE & PUBLIC HEALTH - SUZHOU UNIVERSITY, 1 May 2017 (2017-05-01), XP055895195
Attorney, Agent or Firm:
UNITALEN ATTORNEYS AT LAW (CN)
Download PDF: