Title:
SILK ANTICOAGULANT VASCULAR STENT COVER FILM AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2022/028396
Kind Code:
A1
Abstract:
Disclosed are a silk anticoagulant vascular stent cover film and a preparation method therefor. Silkworm silk is divided into two groups, wherein one group is twisted and combined to obtain a silk thread group, and the other group is a single silk group, and then both groups are boiled with deionized water for degumming. The silk thread group is braided into a tubular structure by means of a braiding machine, and the silk in the single silk group is dissolved in a lithium bromide neutral salt solution to prepare a dissolved silk fibroin solution, the dissolved silk fibroin solution is then poured into a dialysis bag, and the dialysis bag filled with the dissolved silkworm silk fibroin solution is placed in a container containing deionized water for continuous dialysis, so as to obtain a purified silkworm silk fibroin aqueous solution; the silk fibroin aqueous solution is then concentrated by means of a rotary evaporator; and an appropriate amount of a cross-linking agent is then added therein for reaction and the layer-by-layer impregnation and coating of a silk fibroin tubular braid, during which the fibroin tubular braid is impregnated and coated with an anticoagulant drug hirudin alternately or in a hybrid way multiple times, so as to obtain the silk anticoagulant vascular stent cover film. The cover film has good biomechanical properties and long-lasting anticoagulant activity.
Inventors:
SONG GUANGZHOU (CN)
WANG JIANNAN (CN)
YI HONGGEN (CN)
XU JIANMEI (CN)
WANG JIANNAN (CN)
YI HONGGEN (CN)
XU JIANMEI (CN)
Application Number:
PCT/CN2021/110228
Publication Date:
February 10, 2022
Filing Date:
August 03, 2021
Export Citation:
Assignee:
UNIV SOOCHOW (CN)
International Classes:
A61L31/10; A61L27/34; A61L27/54; A61L27/58; A61L31/14; A61L31/16; A61L33/12; C07K1/107; C07K14/435
Foreign References:
| CN112043877A | 2020-12-08 | |||
| CN106902398A | 2017-06-30 | |||
| CN106693082A | 2017-05-24 | |||
| CN106730052A | 2017-05-31 | |||
| CN102274089A | 2011-12-14 | |||
| CN102343113A | 2012-02-08 | |||
| CN103285431A | 2013-09-11 | |||
| CN110075309A | 2019-08-02 | |||
| JP2008073408A | 2008-04-03 |
Other References:
WEI YALI: "Preparation and Hirudin Modification of Silk Fibroin Tubular Scaffold", CHINESE SELECTED DOCTORAL DISSERTATIONS AND MASTER'S THESES DATABASES ( ENGINEERING SCIENCE & TECHNOLOGY I)-SUZHOU UNIVERSITY, 1 March 2014 (2014-03-01), XP055895124, [retrieved on 20220224]
郑忠厚 (ZHENG, ZHONGHOU): "再生丝素蛋白材料的制备与性能研究 (5 Preparation and Properties of Regenerated Silk Fibroin Materials)", 《中国优秀博硕士学位论文全文数据库(硕士)工程科技Ⅰ辑》 (CHINESE SELECTED DOCTORAL DISSERTATIONS AND MASTER'S THESES FULL-TEXT DATABASES (MASTER), ENGINEERING SCIENCE & TECHNOLOGY I), 15 March 2008 (2008-03-15), ISSN: 1674-0246
王琼玉 (WANG, QIONGYU): "水蛭素改性丝素蛋白抗凝血材料的制备及其性能研 (Preparation and Characterization of Hirudin Anticoagulant Modified Silk Fibroin Materials)", 《中国优秀博硕士学位论文全文数据库(硕士)医药卫生科技辑》 (CHINESE SELECTED DOCTORAL DISSERTATIONS AND MASTER'S THESES FULL-TEXT DATABASES (MASTER), MEDICINE & PUBLIC HEALTH), 15 May 2018 (2018-05-15), ISSN: 1674-0246
郑忠厚 (ZHENG, ZHONGHOU): "再生丝素蛋白材料的制备与性能研究 (5 Preparation and Properties of Regenerated Silk Fibroin Materials)", 《中国优秀博硕士学位论文全文数据库(硕士)工程科技Ⅰ辑》 (CHINESE SELECTED DOCTORAL DISSERTATIONS AND MASTER'S THESES FULL-TEXT DATABASES (MASTER), ENGINEERING SCIENCE & TECHNOLOGY I), 15 March 2008 (2008-03-15), ISSN: 1674-0246
王琼玉 (WANG, QIONGYU): "水蛭素改性丝素蛋白抗凝血材料的制备及其性能研 (Preparation and Characterization of Hirudin Anticoagulant Modified Silk Fibroin Materials)", 《中国优秀博硕士学位论文全文数据库(硕士)医药卫生科技辑》 (CHINESE SELECTED DOCTORAL DISSERTATIONS AND MASTER'S THESES FULL-TEXT DATABASES (MASTER), MEDICINE & PUBLIC HEALTH), 15 May 2018 (2018-05-15), ISSN: 1674-0246
Attorney, Agent or Firm:
UNITALEN ATTORNEYS AT LAW (CN)
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