ANTIDIABETIC TRICYCLIC COMPOUNDS - MERCK SHARP & DOHME

Title:

ANTIDIABETIC TRICYCLIC COMPOUNDS

Document Type and Number:

WIPO Patent Application WO/2015/176640

Kind Code:

A1

Abstract:

Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are agonists of G-protein coupled receptor 40 (GPR40) and may be useful in the treatment, prevention and suppression of diseases mediated by the G-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.

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Inventors:

BIFU TESFAYE (US)
BIJU PURAKKATTLE (US)
BLIZZARD TIMOTHY A (US)
CHEN ZHENGXIA (CN)
CLEMENTS MATTHEW J (US)
CUI MINGXIANG (CN)
FRIE JESSICA L (US)
HAGMANN WILLIAM K (US)
HU BIN (CN)
JOSIEN HUBERT (US)
NAIR ANILKUMAR G (US)
PLUMMER CHRISTOPHER W (US)
ZHU CHENG (US)

Application Number:

PCT/CN2015/079262

Publication Date:

November 26, 2015

Filing Date:

May 19, 2015

Export Citation:

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Assignee:

MERCK SHARP & DOHME (US)
BIFU TESFAYE (US)
BIJU PURAKKATTLE (US)
BLIZZARD TIMOTHY A (US)
CHEN ZHENGXIA (CN)
CLEMENTS MATTHEW J (US)
CUI MINGXIANG (CN)
FRIE JESSICA L (US)
HAGMANN WILLIAM K (US)
HU BIN (CN)
JOSIEN HUBERT (US)
NAIR ANILKUMAR G (US)
PLUMMER CHRISTOPHER W (US)
ZHU CHENG (US)

International Classes:

C07D221/16; A61K31/415; A61K31/438; A61P3/10; C07D401/12; C07D405/12

Domestic Patent References:

WO2015051725A1	2015-04-16
WO2014019186A1	2014-02-06

Other References: