Title:
ANTIFIBROTIC INHIBITORY COMPOSITION
Document Type and Number:
WIPO Patent Application WO/2023/140524
Kind Code:
A1
Abstract:
The present invention relates to an antifibrotic inhibitory composition, and to: a pharmaceutical composition for preventing or treating liver fibrosis, comprising, as an active ingredient, a peptide derived from a stem cell culture solution of stem cells transformed with miR150; or a food composition for alleviating liver fibrosis, comprising a peptide derived from a stem cell culture solution of stem cells transformed with miR150. It has been identified that a composition of the present invention exhibits an excellent liver fibrosis inhibitory effect in in vitro and in vivo liver injury models, and thus is expected to be used in the field of liver fibrosis treatment, especially in clinical application technology.
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Inventors:
KIM SE JOON (KR)
KIM KEE HWAN (KR)
KIM OK-HEE (KR)
KIM KEE HWAN (KR)
KIM OK-HEE (KR)
Application Number:
PCT/KR2022/021433
Publication Date:
July 27, 2023
Filing Date:
December 27, 2022
Export Citation:
Assignee:
CATHOLIC UNIV KOREA IND ACADEMIC COOPERATION FOUNDATION (KR)
International Classes:
A61K35/28; A23L33/17; A61K38/16; A61P1/16; A61P43/00; C12N5/0775; C12N15/113
Foreign References:
| KR20180099069A | 2018-09-05 | |||
| KR20200074043A | 2020-06-24 | |||
| US20150232837A1 | 2015-08-20 | |||
| US8759313B2 | 2014-06-24 |
Other References:
PAIK KWANG YEOL, KIM KEE-HWAN, PARK JUNG HYUN, LEE JAE IM, KIM OK-HEE, HONG HA-EUN, SEO HAEYEON, CHOI HO JOONG, AHN JOSEPH, LEE TA: "A novel antifibrotic strategy utilizing conditioned media obtained from miR-150-transfected adipose-derived stem cells: validation of an animal model of liver fibrosis", EXPERIMENTAL AND MOLECULAR MEDICINE, SEOUL, KR, vol. 52, no. 3, 1 March 2020 (2020-03-01), KR , pages 438 - 449, XP055904697, ISSN: 1226-3613, DOI: 10.1038/s12276-020-0393-1
Attorney, Agent or Firm:
LEE, Myoung-Jin (KR)
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