Title:
ANTIFUNGAL COMPOSITION INCLUDING POLYCYCLIC PEPTIDE COMPOUND AND METHOD FOR PRODUCING SAME
Document Type and Number:
WIPO Patent Application WO/2012/093859
Kind Code:
A3
Abstract:
The present invention provides an antifungal composition including as an active ingredient a AN1542 strain (accession number: KCTC 12113BP) in a Streptomyces sp. having antifungal activity, an antifungal composition including a compound represented by Formula 1 or Formula 2 or a strain producing same as an active ingredient, and a method for preparing the compound. The compound or the strain of the present invention exhibits strong antifungal activity to pathogenic microorganisms and antibiotics-tolerant bacteria, and in particular, can be useful in treating contagious diseases due to super bacteria by exhibiting strong antifungal activity to MRSA, QRSA, VRSA, and VRE.
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Inventors:
KIM WON GON (KR)
KWON YUN JU (KR)
SOHN MI JIN (KR)
KWON YUN JU (KR)
SOHN MI JIN (KR)
Application Number:
PCT/KR2012/000097
Publication Date:
November 08, 2012
Filing Date:
January 04, 2012
Export Citation:
Assignee:
KOREA RES INST OF BIOSCIENCE (KR)
KIM WON GON (KR)
KWON YUN JU (KR)
SOHN MI JIN (KR)
KIM WON GON (KR)
KWON YUN JU (KR)
SOHN MI JIN (KR)
International Classes:
A61K31/404; A61P31/00; A61P31/04
Foreign References:
| US6365571B1 | 2002-04-02 | |||
| JPH03264535A | 1991-11-25 | |||
| US5140101A | 1992-08-18 |
Other References:
HARUO TANAKA ET AL.: "Chloropeptins, New Anti-HIV Antibiotics Inhibiting gp120-CD4 Binding from Streptomyces sp. I. Taxonomy, Fermentation, Isolation, and Physico-chemical Properties and Biological Activities", THE JOURNAL OF ANTIBIOTICS, vol. 50, no. 1, 1997, pages 58 - 65, XP002925771
HIROYUKI KOBAYASHI ET AL.: "Neuroprotectins A and B, Bicyclohexapeptides Protecing Chick Telencephalic Neurons form Excitotoxicity, I. Fermentation, Isolation, Physico-chemical properties and Biological Activity", THE JOURNAL OF ANTIBIOTICS, vol. 54, no. 12, 2001, pages 1013 - 1018
SHEO B. SINGH ET AL.: "The Complestatins as HIV-1 Integrase Inhibitors. Efficient Isolation, Structure Elucidation, and Inhibitory Activities of Isocomplestatin, Chloropeptin I, New Complestatins, A and B, and Acid- Hydrolysis Products of Chloropeptin I", JOURNAL OF NATURAL PRODUCTS, vol. 64, no. 7, 2001, pages 874 - 882, XP002265327, DOI: doi:10.1021/np000632z
HIROYUKI KOBAYASHI ET AL.: "Neuroprotectins A and B, Bicyclohexapeptides Protecing Chick Telencephalic Neurons form Excitotoxicity, I. Fermentation, Isolation, Physico-chemical properties and Biological Activity", THE JOURNAL OF ANTIBIOTICS, vol. 54, no. 12, 2001, pages 1013 - 1018
SHEO B. SINGH ET AL.: "The Complestatins as HIV-1 Integrase Inhibitors. Efficient Isolation, Structure Elucidation, and Inhibitory Activities of Isocomplestatin, Chloropeptin I, New Complestatins, A and B, and Acid- Hydrolysis Products of Chloropeptin I", JOURNAL OF NATURAL PRODUCTS, vol. 64, no. 7, 2001, pages 874 - 882, XP002265327, DOI: doi:10.1021/np000632z
Attorney, Agent or Firm:
SON, Min (6th Floor, City Air Tower,,36, Teheran-ro 87 gil, Samsung-dong, Gangnam-gu Seoul 135-973, KR)
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