Title:
ANTIGEN-BINDING MOLECULES CAPABLE OF BINDING CD3 AND CD137 BUT NOT SIMULTANEOUSLY
Document Type and Number:
WIPO Patent Application WO/2020/067419
Kind Code:
A1
Abstract:
The present invention relates to antigen-binding molecules binding to CD3 and CD137 (4-1BB); compositions comprising the antigen-binding molecule; and methods of using the same. The present invention provides antigen-binding molecules comprising: an antibody variable region that is capable of binding to CD3 and CD137 (4-1BB), but does not bind to CD3 and CD137 at the same time; and a variable region binding to a third antigen different from CD3 and CD137. Such antigen binding molecules exhibit enhanced T-cell dependent cytotoxity activity induced by these antigen-binding molecules through binding to the three different antigens.
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Inventors:
HO SHU WEN SAMANTHA (SG)
FENG SHU (SG)
FENG SHU (SG)
Application Number:
PCT/JP2019/038138
Publication Date:
April 02, 2020
Filing Date:
September 27, 2019
Export Citation:
Assignee:
CHUGAI PHARMACEUTICAL CO LTD (JP)
International Classes:
C07K16/28; C07K16/30; C07K16/46; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/13; C12P21/08
Domestic Patent References:
| WO2019111871A1 | 2019-06-13 |
Foreign References:
| EP3070168A1 | 2016-09-21 | |||
| EP3219724A1 | 2017-09-20 | |||
| EP3130606A1 | 2017-02-15 |
Other References:
See also references of EP 3856785A4
Attorney, Agent or Firm:
HARUNA, Masao et al. (JP)
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