Title:
ANTIMALARIAL DRUG, MALARIA TREATMENT METHOD, SCREENING METHOD FOR CANDIDATE SUBSTANCES FOR MALARIA TREATMENT, MARKER OF MALARIA SEVERITY, AND METHOD AND TEST REAGENT FOR TESTING RISK OF SEVERE MALARIA
Document Type and Number:
WIPO Patent Application WO/2019/107387
Kind Code:
A1
Abstract:
Provided is a novel antimalarial drug. This antimalarial drug is characterized by containing a binding inhibitor that inhibits binding of RIFIN proteins to leukocyte immunoglobulin-like receptor subfamily B member 1 (LILRB1) protein, an inducer of said binding inhibitor, or an RIFIN or LILRB1 expression inhibitor.
Inventors:
ARASE HISASHI (JP)
HIRAYASU FUMIJI (JP)
HIRAYASU KOUYUKI (JP)
HIRAYASU FUMIJI (JP)
HIRAYASU KOUYUKI (JP)
Application Number:
PCT/JP2018/043698
Publication Date:
June 06, 2019
Filing Date:
November 28, 2018
Export Citation:
Assignee:
UNIV OSAKA (JP)
International Classes:
A61K45/00; A61K31/7088; A61K39/39; A61K39/395; A61K48/00; A61P33/06; C07K14/445; C07K14/705; C12N15/12; C12N15/30; G01N33/15; G01N33/50; G01N33/68
Other References:
TAN, J. ET AL.: "A LAIR1 insertion generates broadly reactive antibodies against malaria variant antigens", NATURE, vol. 529, 2016, pages 105 - 109, XP055296952, doi:10.1038/nature16450
GOEL, S. ET AL.: "RIFINs are adhesins implicated in severe Plasmodium falciparum malaria", NATURE MEDICINE, vol. 21, no. 4, 9 March 2015 (2015-03-09), pages 314 - 317, XP055615249
CH 'NG, J. H. ET AL.: "Epitopes of anti-RIFIN antibodies and characterization of rif-expressing Plasmodium falciparum parasites by RNA sequencing", SCIENTIFIC REPORTS, vol. 7, no. 43190, 24 February 2017 (2017-02-24), pages 1 - 11, XP055615254
SAITO, F. ET AL.: "Immune evasion of Plasmodium falciparum by RIFIN via inhibitory receptors", NATURE, vol. 552, 29 November 2017 (2017-11-29) - 7 December 2017 (2017-12-07), pages 101 - 105, XP055615261
KAUR, J. ET AL.: "2TM proteins': an antigenically diverse superfamily with variable functions and export pathways", PEERJ, vol. 6, no. e4757, 11 May 2018 (2018-05-11), pages 1 - 28, XP055615265
ABDEL-LATIF, M. S. ET AL.: "Antibodies to Plasmodium falciparum Rifin Proteins Are Associated with Rapid Parasite Clearance and Asymptomatic Infections", INFECT. IMMUN., vol. 71, no. 11, November 2003 (2003-11-01), pages 6229 - 6233, XP055615271
WAHLGREN, M. ET AL.: "Variant surface antigens of Plasmodium falciparum and their roles in severe malaria", NATURE REVIEWS MICROBIOLOGY, vol. 15, no. 8, 12 June 2017 (2017-06-12) - August 2017 (2017-08-01), pages 479 - 491, XP055615272
KALMBACH, Y. ET AL.: "Increase in annexin V-positive B cells expressing LILRB1/ILT2/ CD 85j in malaria", EUROPEAN CYTOKINE NETWORK, vol. 17, no. 3, September 2006 (2006-09-01) - 6 September 2006 (2006-09-06), pages 175 - 180, XP055615273
GOEL, S. ET AL.: "RIFINs are adhesins implicated in severe Plasmodium falciparum malaria", NATURE MEDICINE, vol. 21, no. 4, 9 March 2015 (2015-03-09), pages 314 - 317, XP055615249
CH 'NG, J. H. ET AL.: "Epitopes of anti-RIFIN antibodies and characterization of rif-expressing Plasmodium falciparum parasites by RNA sequencing", SCIENTIFIC REPORTS, vol. 7, no. 43190, 24 February 2017 (2017-02-24), pages 1 - 11, XP055615254
SAITO, F. ET AL.: "Immune evasion of Plasmodium falciparum by RIFIN via inhibitory receptors", NATURE, vol. 552, 29 November 2017 (2017-11-29) - 7 December 2017 (2017-12-07), pages 101 - 105, XP055615261
KAUR, J. ET AL.: "2TM proteins': an antigenically diverse superfamily with variable functions and export pathways", PEERJ, vol. 6, no. e4757, 11 May 2018 (2018-05-11), pages 1 - 28, XP055615265
ABDEL-LATIF, M. S. ET AL.: "Antibodies to Plasmodium falciparum Rifin Proteins Are Associated with Rapid Parasite Clearance and Asymptomatic Infections", INFECT. IMMUN., vol. 71, no. 11, November 2003 (2003-11-01), pages 6229 - 6233, XP055615271
WAHLGREN, M. ET AL.: "Variant surface antigens of Plasmodium falciparum and their roles in severe malaria", NATURE REVIEWS MICROBIOLOGY, vol. 15, no. 8, 12 June 2017 (2017-06-12) - August 2017 (2017-08-01), pages 479 - 491, XP055615272
KALMBACH, Y. ET AL.: "Increase in annexin V-positive B cells expressing LILRB1/ILT2/ CD 85j in malaria", EUROPEAN CYTOKINE NETWORK, vol. 17, no. 3, September 2006 (2006-09-01) - 6 September 2006 (2006-09-06), pages 175 - 180, XP055615273
Attorney, Agent or Firm:
TSUJIMARU Koichiro et al. (JP)
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