Title:
ANTIPARASITIC AGENTS AND METHODS
Document Type and Number:
WIPO Patent Application WO/2023/215819
Kind Code:
A3
Abstract:
Methods of reducing viability of a parasite in a subject involve administering an effective amount of an inhibitor of guanosine-5'-triphosphate cyclohydrolase I (GCH) to the subject. Methods of identifying an agent that reduces viability of an apicomplexan parasite involve culturing an apicomplexan parasite in a cell culture; adding an agent to the cell culture; and detecting a concentration of one or more of 7,8-dihydroneopterin triphosphate, 6-pyruvoyl-tetrahydropterin, tetrahydrobiopterin, tetrahydrofolate, folate, dihydrofolate, or dihydrobiopterin in the cell culture after a period of time.
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Inventors:
GIULIANO CHRISTOPHER JOSEPH (US)
LOURIDO SEBASTIAN (US)
LOURIDO SEBASTIAN (US)
Application Number:
PCT/US2023/066592
Publication Date:
January 18, 2024
Filing Date:
May 04, 2023
Export Citation:
Assignee:
WHITEHEAD INST BIOMEDICAL RES (US)
International Classes:
A61P33/02; A61K31/505; A61K31/522; A61K31/63; C12Q1/02
Domestic Patent References:
| WO1998003661A2 | 1998-01-29 |
Foreign References:
| US20050197341A1 | 2005-09-08 | |||
| US20060286574A1 | 2006-12-21 | |||
| US20100055201A1 | 2010-03-04 | |||
| US20020052384A1 | 2002-05-02 | |||
| US20030109529A1 | 2003-06-12 |
Other References:
GAUTAM BUDHAYASH, SINGH SATENDRA: "COMPARATIVE MODELING OF GTP CYCLOHYDROLASE I IN TOXOPLASMA GONDII", INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES REVIEW AND RESEARCH, GLOBAL RESEARCH ONLINE PUBLISHING HOUSE, IN, vol. 4, no. 3, 1 September 2010 (2010-09-01), IN , pages 142 - 145, XP093132364, ISSN: 0976-044X
HEINBERG ADINA, SIU EDWIN, STERN CHAYA, LAWRENCE ELIZABETH A., FERDIG MICHAEL T., DEITSCH KIRK W., KIRKMAN LAURA A.: "Direct evidence for the adaptive role of copy number variation on antifolate susceptibility in Plasmodium falciparum", MOLECULAR MICROBIOLOGY, WILEY-BLACKWELL PUBLISHING LTD, GB, vol. 88, no. 4, 1 May 2013 (2013-05-01), GB , pages 702 - 712, XP093132365, ISSN: 0950-382X, DOI: 10.1111/mmi.12162
DATABASE PubChem 19 December 2011 (2011-12-19), ANONYMOUS : "2,4-Diamino-6-hydroxypyrimidine", XP093132366, Database accession no. SID 74814
YUN MI-KUNG, YINAN WU, ZHENMEI LI, YING ZHAO, M. BRETT WADDELL, ANTONIO M. FERREIRA, RICHARD E. LEE, DONALD BASHFORD, STEPHEN W. W: "Catalysis and Sulfa Drug Resistance in Dihydropteroate Synthase", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, US, vol. 335, no. 6072, 2 March 2012 (2012-03-02), US , pages 1110 - 1114, XP093132372, ISSN: 0036-8075, DOI: 10.1126/science.1215802
GIULIANO CHRISTOPHER J., WEI KENNETH J., HARLING FAYE M., WALDMAN BENJAMIN S., FARRINGER MADELINE A., BOYDSTON ELIZABETH A., LAN T: "Functional profiling of the Toxoplasma genome during acute mouse infection", BIORXIV, 6 March 2023 (2023-03-06), pages 1 - 56, XP093132375, DOI: 10.1101/2023.03.05.531216
HEINBERG ADINA, SIU EDWIN, STERN CHAYA, LAWRENCE ELIZABETH A., FERDIG MICHAEL T., DEITSCH KIRK W., KIRKMAN LAURA A.: "Direct evidence for the adaptive role of copy number variation on antifolate susceptibility in Plasmodium falciparum", MOLECULAR MICROBIOLOGY, WILEY-BLACKWELL PUBLISHING LTD, GB, vol. 88, no. 4, 1 May 2013 (2013-05-01), GB , pages 702 - 712, XP093132365, ISSN: 0950-382X, DOI: 10.1111/mmi.12162
DATABASE PubChem 19 December 2011 (2011-12-19), ANONYMOUS : "2,4-Diamino-6-hydroxypyrimidine", XP093132366, Database accession no. SID 74814
YUN MI-KUNG, YINAN WU, ZHENMEI LI, YING ZHAO, M. BRETT WADDELL, ANTONIO M. FERREIRA, RICHARD E. LEE, DONALD BASHFORD, STEPHEN W. W: "Catalysis and Sulfa Drug Resistance in Dihydropteroate Synthase", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, US, vol. 335, no. 6072, 2 March 2012 (2012-03-02), US , pages 1110 - 1114, XP093132372, ISSN: 0036-8075, DOI: 10.1126/science.1215802
GIULIANO CHRISTOPHER J., WEI KENNETH J., HARLING FAYE M., WALDMAN BENJAMIN S., FARRINGER MADELINE A., BOYDSTON ELIZABETH A., LAN T: "Functional profiling of the Toxoplasma genome during acute mouse infection", BIORXIV, 6 March 2023 (2023-03-06), pages 1 - 56, XP093132375, DOI: 10.1101/2023.03.05.531216
Attorney, Agent or Firm:
ALBERT, Christopher K. et al. (US)
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