Title:
ANTISENSE OLIGONUCLEOTIDE COMPLEX
Document Type and Number:
WIPO Patent Application WO/2023/105898
Kind Code:
A1
Abstract:
The present invention provides an antisense oligonucleotide complex which includes an antisense oligonucleotide and a complementary strand which includes a sequence which is complementary to said antisense oligonucleotide, said complex being characterized in that said antisense oligonucleotide has a single strand-structured toe hold, and said complementary strand has nuclease resistance throughout the entire length thereof. As a result, said complex exhibits an antisense effect and has reduced toxicity.
Inventors:
YAMAMOTO TSUYOSHI (JP)
TERADA CHISATO (JP)
TERADA CHISATO (JP)
Application Number:
PCT/JP2022/036699
Publication Date:
June 15, 2023
Filing Date:
September 30, 2022
Export Citation:
Assignee:
LIID PHARMACEUTICALS INC (JP)
International Classes:
C12N15/113; A61K31/713; A61P3/06; A61P43/00; C12N15/10
Domestic Patent References:
| WO2019181946A1 | 2019-09-26 |
Foreign References:
| JP2015502134A | 2015-01-22 |
Other References:
SU SU LEI MON; KOTARO YOSHIOKA; CHUNYAN JIA; TAIKI KUNIEDA; YUTARO ASAMI; KIE YOSHIDA‐TANAKA; WENYING PIAO; HIROYA KUWAHARA; KAZUT: "Highly efficient gene silencing in mouse brain by overhanging‐duplex oligonucleotides via intraventricular route", FEBS LETTERS, ELSEVIER, AMSTERDAM., NL, vol. 594, no. 9, 6 February 2020 (2020-02-06), NL , pages 1413 - 1423, XP071257332, ISSN: 0014-5793, DOI: 10.1002/1873-3468.13742
DAVID YU ZHANG, ERIK WINFREE: "Control of DNA Strand Displacement Kinetics Using Toehold Exchange", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, vol. 131, no. 47, 2 December 2009 (2009-12-02), pages 17303 - 17314, XP055530934, ISSN: 0002-7863, DOI: 10.1021/ja906987s
DAVID YU ZHANG, ERIK WINFREE: "Control of DNA Strand Displacement Kinetics Using Toehold Exchange", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, vol. 131, no. 47, 2 December 2009 (2009-12-02), pages 17303 - 17314, XP055530934, ISSN: 0002-7863, DOI: 10.1021/ja906987s
Attorney, Agent or Firm:
MURAOKA, Koichiro et al. (JP)
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