Title:
ANTIVIRAL COMPOUND AND METHOD FOR PREPARATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/142727
Kind Code:
A1
Abstract:
Disclosed are an antiviral compound and method for preparation thereof. The structural formula of the compound is as shown in formula I; in formula (I), R 1 is selected from monosubstituted or polysubstituted H, F, methyl, and trifluoromethyl, and is preferably H; R 2 is selected from H and straight-chain or substituted alkane (C1-C6), and is preferably methyl or isopropyl; R 3 is selected from monosubstituted or polysubstituted H, Cl, Br, and F, and is preferably Cl; R 4 is selected from straight-chain or substituted alkane (C1-C6), and is preferably methyl ethyl, or propyl. Experiments prove that the compound of the present invention not only has a good inhibitory effect on influenza A virus subtype H1N1, but also has a good inhibitory effect on coronaviruses, no toxicity to normal human cells is observed, and the degree of inflammatory response can be inhibited while resisting viruses.
Inventors:
WANG WEI (CN)
LU YONGZHANG (CN)
TAN JINHUI (CN)
LU YONGZHANG (CN)
TAN JINHUI (CN)
Application Number:
PCT/CN2021/128879
Publication Date:
July 07, 2022
Filing Date:
November 05, 2021
Export Citation:
Assignee:
GUANGDONG ZHONGKE MEDICINE R&D LTD (CN)
International Classes:
C07D277/50; A61K31/426; A61K31/454; A61P11/00; A61P31/14; A61P31/16
Foreign References:
| CN112707874A | 2021-04-27 | |||
| CN108503604A | 2018-09-07 | |||
| CN107382902A | 2017-11-24 | |||
| CN107459496A | 2017-12-12 | |||
| CN107375279A | 2017-11-24 |
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