Title:
APPLICATION OF DIVALENT MANGANESE IN PREPARING IMMUNITY ENHANCING DRUG OR ANTITUMOR DRUG
Document Type and Number:
WIPO Patent Application WO/2021/077566
Kind Code:
A1
Abstract:
An application of divalent manganese in preparing an immunity enhancing drug or anti-tumor drug, specifically relating to divalent manganese being used as an activator of dendritic cells, macrophages or CD8 positive T cells, and a use thereof as an activator of dendritic cells, macrophages or CD8 positive T cells. Further provided is divalent manganese being used as a sensitizer for enhancing the effect of an antitumor drug, which can significantly reduce the dose of the antitumor drug when applied in combination with the antitumor drugs, thus achieving a good therapeutic effect.
Inventors:
JIANG ZHENGFAN (CN)
LYU MENGZE (CN)
WANG CHENGUANG (CN)
ZHANG RUI (CN)
LYU MENGZE (CN)
WANG CHENGUANG (CN)
ZHANG RUI (CN)
Application Number:
PCT/CN2019/124098
Publication Date:
April 29, 2021
Filing Date:
December 09, 2019
Export Citation:
Assignee:
UNIV BEIJING (CN)
International Classes:
A61K33/32; A61K39/39; A61K45/06; A61P35/00; A61P37/04
Foreign References:
| CN107412260A | 2017-12-01 | |||
| CN107412260A | 2017-12-01 | |||
| CN101151532A | 2008-03-26 | |||
| CN107456575A | 2017-12-12 | |||
| CN102515276A | 2012-06-27 | |||
| CN1542449A | 2004-11-03 |
Other References:
WANG CHENGUANG, GUAN YUKUN, LV MENGZE, ZHANG RUI, GUO ZHAOYING, WEI XIAOMING, DU XIAOXIA, YANG JING, LI TONG, WAN YI, SU XIAODONG,: "Manganese Increases the Sensitivity of the cGAS-STING Pathway for Double-Stranded DNA and Is Required for the Host Defense against DNA Viruses", SCIENCE NEWS, no. 2, 15 April 2019 (2019-04-15), pages 78, XP055805887, ISSN: 1671-6582
Attorney, Agent or Firm:
BEIJING ORIGINTELLIGENCE IP LAW FIRM (CN)
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