Title:
APPLICATION OF GLUCOSAMINE IN PREPARATION OF NON-ALCOHOLIC FATTY TREATMENT DRUGS
Document Type and Number:
WIPO Patent Application WO/2022/089591
Kind Code:
A1
Abstract:
The application of glucosamine in the preparation of drugs for the treatment of non-alcoholic fatty liver disease and diabetes. Experiments have proven that glucosamine at a daily dose of 300-600 mg/kg can improve insulin resistance, glycolipid metabolism disorder, and liver lipid accumulation in mice with non-alcoholic fatty liver disease, improve abnormal liver function, enhance antioxidant capacity, and reduce body inflammation and serum endotoxin levels, and thus show that glucosamine has a certain therapeutic effect on non-alcoholic fatty liver disease.
Inventors:
SU ZHENGQUAN (CN)
CAO HUA (CN)
BAI YAN (CN)
CAO HUA (CN)
BAI YAN (CN)
Application Number:
PCT/CN2021/127473
Publication Date:
May 05, 2022
Filing Date:
October 29, 2021
Export Citation:
Assignee:
UNIV GUANGDONG PHARM (CN)
International Classes:
A61K31/7008; A61P1/16; A61P3/06; A61P3/10; A61P5/50; A61P29/00; A61P35/00; A61P39/02; A61P39/06
Foreign References:
| CN112190586A | 2021-01-08 | |||
| CN103550230A | 2014-02-05 | |||
| CN105616430A | 2016-06-01 |
Other References:
HWANG JI-SUN; PARK JI-WON; NAM MOON-SUK; CHO HYEONGJIN; HAN INN-OC: "Glucosamine Enhances Body Weight Gain and Reduces Insulin Response in Mice Fed Chow Diet but Mitigates Obesity, Insulin Resistance and Impaired Glucose Tolerance in Mice High-Fat Diet", METABOLISM, vol. 64, no. 3, 31 May 2015 (2015-05-31), US , pages 368 - 379, XP029135142, ISSN: 0026-0495, DOI: 10.1016/j.metabol.2014.11.005
JIN LIMING,YANG YAN,LIU WANSHUN,HAN BAOQIN,TIAN WENJIE,FAN SHENGDI: "Protective effects of D-Glucosamine Against Carbon Tetrachloride-Induced Liver Damage in Mice", JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES), vol. 44, no. 1, 20 January 2009 (2009-01-20), pages 122 - 125, XP055926674, ISSN: 1671-6825, DOI: 10.13705/j.issn.1671-6825.2009.01.023
JIN LIMING,YANG YAN,LIU WANSHUN,HAN BAOQIN,TIAN WENJIE,FAN SHENGDI: "Protective effects of D-Glucosamine Against Carbon Tetrachloride-Induced Liver Damage in Mice", JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES), vol. 44, no. 1, 20 January 2009 (2009-01-20), pages 122 - 125, XP055926674, ISSN: 1671-6825, DOI: 10.13705/j.issn.1671-6825.2009.01.023
Attorney, Agent or Firm:
GUANGZHOU KEWOYUAN PATENT AGENCY CO. , LTD. (CN)
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