Title:
COMPLEX SALT COMPOUND OF FLAVONOID GLYCOSIDE-ORGANIC AMINE TYROSINE KINASE INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/089590
Kind Code:
A1
Abstract:
The present application relates to a complex salt compound of a flavonoid glycoside and an organic amine tyrosine kinase inhibitor. The flavonoid glycoside has a general structural formula as represented by formula (1), wherein each of R1-R9 is independently selected from -H, -OH, and C1-C6 alkyl, alkoxy or substituted alkyl, and at least one of R1 and R2 is selected from -OH. The present application also relates to a preparation method for the complex salt compound. Further, the present application also relates to a pharmaceutical composition containing a therapeutically effective amount of the compound and the use thereof and a complex salt nanoparticle obtained by nano-milling the complex salt compound and the use thereof. [Formula I]
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Inventors:
WANG HUALU (CN)
WANG LUYING (CN)
WANG LUYING (CN)
Application Number:
PCT/CN2021/127471
Publication Date:
May 05, 2022
Filing Date:
October 29, 2021
Export Citation:
Assignee:
HANGZHOU LALIN INTELLIGENCE SCIENCE AND TECH CO LTD (CN)
International Classes:
C07H17/07; A61K31/366; A61K36/539; A61P35/00
Domestic Patent References:
| WO2011068403A2 | 2011-06-09 |
Foreign References:
| CN109432086A | 2019-03-08 | |||
| CN108697646A | 2018-10-23 | |||
| CN106103429A | 2016-11-09 | |||
| CN101732417A | 2010-06-16 |
Other References:
LI WENLIANG, ZENG JIAN-GUO, ZHANG XUE, LIU FA-BAO, DU FANG-LU, XU LI: "The 1H NMR Spectral Analyses of Chelerytrine-baicalin, Sanguinarine-baicalin and Related Ion-pair Compounds", CHEMICAL WORLD, SHANGHAISHI HUAXUE HUAGONG XUEHUI-WUXI INSTITUTE OF LIGHT INDUSTRY, 214086, CN, vol. 53, no. 4, 30 April 2012 (2012-04-30), CN , pages 211 - 213, XP055924776, ISSN: 0367-6358, DOI: 10.19500/j.cnki.0367-6358.2012.04.006
Attorney, Agent or Firm:
ACIP LAW OFFICES (CN)
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