Title:
APPLICATION OF ISX-9 IN TREATMENT OF AGING-RELATED CIRCADIAN RHYTHM AMPLITUDE DECREASE AND SLEEP DISORDER
Document Type and Number:
WIPO Patent Application WO/2023/130675
Kind Code:
A1
Abstract:
The present invention provides a use of ISX-9. Specifically, ISX-9 can be used for preparing a composition for one or more uses selected from a group consisting of: (i) prevention and/or treatment of circadian rhythm disorders; (ii) prevention and/or treatment of sleep disorders; (iii) increase of circadian rhythm amplitude; and/or (iv) improvement of the activity or expression of CamkIIδ protein. The active ingredient ISX-9 of the present invention can stably, continuously, and effectively treat circadian rhythm disorders and related diseases thereof in elderly objects in in vivo environments, ex vitro environments, and in vitro environments.
Inventors:
CHANG HUNG-CHUN (CN)
TANG YUN-CHI (CN)
TANG YUN-CHI (CN)
Application Number:
PCT/CN2022/099218
Publication Date:
July 13, 2023
Filing Date:
June 16, 2022
Export Citation:
Assignee:
CENTER FOR EXCELLENCE IN BRAIN SCIENCE AND INTELLIGENCE TECH CHINESE ACADEMY OF SCIENCES (CN)
SHANGHAI INST OF NUTRITION AND HEALTH CHINESE ACADEMY OF SCIENCES (CN)
SHANGHAI INST OF NUTRITION AND HEALTH CHINESE ACADEMY OF SCIENCES (CN)
International Classes:
A61K31/422; A61P25/20
Domestic Patent References:
| WO2008046072A2 | 2008-04-17 |
Foreign References:
| CN104350051A | 2015-02-11 | |||
| CN108473953A | 2018-08-31 | |||
| CN109640998A | 2019-04-16 |
Other References:
KON NAOHIRO, YOSHIKAWA TOMOKO, HONMA SATO, YAMAGATA YOKO, YOSHITANE HIKARI, SHIMIZU KIMIKO, SUGIYAMA YASUNORI, HARA CHIHIRO, KAMES: "CaMKII is essential for the cellular clock and coupling between morning and evening behavioral rhythms", GENES & DEVELOPMENT, COLD SPRING HARBOR LABORATORY PRESS, PLAINVIEW, NY., US, vol. 28, no. 10, 15 May 2014 (2014-05-15), US , pages 1101 - 1110, XP093076887, ISSN: 0890-9369, DOI: 10.1101/gad.237511.114
GALINATO M H, LOCKNER J W, FANNON-PAVLICH M J, SOBIERAJ J C, STAPLES M C, SOMKUWAR S S, GHOFRANIAN A, CHAING S, NAVARRO A I, JOEA : "A synthetic small-molecule Isoxazole-9 protects against methamphetamine relapse", MOLECULAR PSYCHIATRY, NATURE PUBLISHING GROUP UK, LONDON, vol. 23, no. 3, 1 March 2018 (2018-03-01), London, pages 629 - 638, XP093076888, ISSN: 1359-4184, DOI: 10.1038/mp.2017.46
SCHNEIDER, J.W. ET AL.: "Small-Molecule Activation of Neuronal Cell Fate", NATURE CHEMICAL BIOLOGY, vol. 4, no. 7, 15 June 2008 (2008-06-15), XP055345539, ISSN: 1552-4450, DOI: 10.1038/nchembio.95
GALINATO M H, LOCKNER J W, FANNON-PAVLICH M J, SOBIERAJ J C, STAPLES M C, SOMKUWAR S S, GHOFRANIAN A, CHAING S, NAVARRO A I, JOEA : "A synthetic small-molecule Isoxazole-9 protects against methamphetamine relapse", MOLECULAR PSYCHIATRY, NATURE PUBLISHING GROUP UK, LONDON, vol. 23, no. 3, 1 March 2018 (2018-03-01), London, pages 629 - 638, XP093076888, ISSN: 1359-4184, DOI: 10.1038/mp.2017.46
SCHNEIDER, J.W. ET AL.: "Small-Molecule Activation of Neuronal Cell Fate", NATURE CHEMICAL BIOLOGY, vol. 4, no. 7, 15 June 2008 (2008-06-15), XP055345539, ISSN: 1552-4450, DOI: 10.1038/nchembio.95
Attorney, Agent or Firm:
XU&PARTNERS, LLC. (CN)
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