Title:
AROMATIC AMIDE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/078569
Kind Code:
A1
Abstract:
The present invention relates to an aromatic amide derivative, a preparation method therefor, and a use of a pharmaceutical composition comprising same in medicine. Specifically, the present invention relates to an aromatic amide derivative represented by general formula (I), a preparation method therefor, a pharmaceutically acceptable salt thereof, and a use thereof as a therapeutic agent, especially, a KIF18A inhibitor, wherein the definitions of substituents in general formula (I) are the same as those in the description.
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Inventors:
QIU ZONGXING (CN)
CAO HAI (CN)
PENG JILEI (CN)
WANG ZEFENG (CN)
ZHANG PANPAN (CN)
YE CHENG (CN)
GUO ZE (CN)
XU DAIWANG (CN)
ZHOU HOUJIANG (CN)
CAO HAI (CN)
PENG JILEI (CN)
WANG ZEFENG (CN)
ZHANG PANPAN (CN)
YE CHENG (CN)
GUO ZE (CN)
XU DAIWANG (CN)
ZHOU HOUJIANG (CN)
Application Number:
PCT/CN2023/124209
Publication Date:
April 18, 2024
Filing Date:
October 12, 2023
Export Citation:
Assignee:
ZHEJIANG HISUN PHARM CO LTD (CN)
SHANGHAI ARYL PHARMTECH CO LTD (CN)
SHANGHAI ARYL PHARMTECH CO LTD (CN)
International Classes:
C07D401/12; A61K31/4427; A61P35/00; C07D401/14; C07D405/14; C07D413/14; C07D491/044
Domestic Patent References:
| WO2020132651A1 | 2020-06-25 | |||
| WO2021211549A1 | 2021-10-21 |
Foreign References:
| CN114391012A | 2022-04-22 | |||
| CN114302880A | 2022-04-08 |
Other References:
TAMAYO, N. A. ET AL.: "Targeting the Mitotic Kinesin KIF18A in Chromosomally Unstable Cancers: Hit Optimization Toward an In Vivo Chemical Probe", J. MED. CHEM., vol. 65, no. 6, 14 March 2022 (2022-03-14), XP093064019, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.1c02030
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