ASSAY FOR THE DIAGNOSIS OF A NEUROLOGICAL DISEASE - EUROIMMUN MEDIZINISCHE LABORDIAGNOSTIKA AG

Title:

ASSAY FOR THE DIAGNOSIS OF A NEUROLOGICAL DISEASE

Document Type and Number:

WIPO Patent Application WO/2017/190834

Kind Code:

A8

Abstract:

The present invention relates to a diagnostically useful carrier comprising a means for capturing Neurogranin, a means for capturing BACE1 and preferably a means for capturing one or more additional biomarkers; a kit comprising the diagnostically useful carrier, optionally further comprising a means for detecting Neurogranin, a means for detecting BACE1 and preferably a means for detecting the one or more additional biomarkers; and a method comprising the steps contacting a sample from a subject with a means for capturing Neurogranin, isolating the means for capturing Neurogranin from the sample and contacting a sample from a subject with a means for capturing BACE1 and isolating the means for capturing BACE1 from the sample. The diagnosis aims to distinguish a neurodegenerative disease, preferably mild Alzheimer's disease, and depression with or without cognitive impairment.

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Inventors:

VANMECHELEN EUGEEN (BE)
DE VOS ANN (BE)
ENGELBORGHS SEBASTIAAN (BE)
PETERS OLIVER (DE)
SCHIPKE CAROLA (DE)

Application Number:

PCT/EP2017/000549

Publication Date:

October 25, 2018

Filing Date:

May 03, 2017

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Assignee:

EUROIMMUN MEDIZINISCHE LABORDIAGNOSTIKA AG (DE)
ADX NEUROSCIENCES NV (BE)

International Classes:

G01N33/68

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