Title:
ASSAYS AND METHODS FOR DETERMINING THE RESPONSIVENESS OF AN INDIVIDUAL SUBJECT TO A THERAPEUTIC AGENT
Document Type and Number:
WIPO Patent Application WO/2015/089380
Kind Code:
A3
Abstract:
Provided herein are methods for determining the functional status of a cellular pathway in a diseased cell sample obtained from an individual subject. These methods involve contacting a diseased cell sample obtained from the subject with a perturbing agent (e.g., an activating agent) known to perturb a specific cellular pathway when the pathway is functioning normally. A change in one or more physiological response parameters in the presence of the perturbing agent indicates that the cellular pathway targeted by the perturbing agent is functional in the individual subject. Methods of selecting a targeted therapeutic agent for an individual subject are also provided.
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Inventors:
LAING LANCE GAVIN (US)
SULLIVAN BRIAN FRANCIS (US)
SULLIVAN BRIAN FRANCIS (US)
Application Number:
PCT/US2014/069980
Publication Date:
July 23, 2015
Filing Date:
December 12, 2014
Export Citation:
Assignee:
CELCUITY LLC (US)
International Classes:
G01N33/50; A61K33/243
Domestic Patent References:
| WO2003008530A2 | 2003-01-30 | |||
| WO2012157647A1 | 2012-11-22 | |||
| WO2007081779A2 | 2007-07-19 |
Other References:
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RICHARD J ABLIN ET AL: "Prostate transglutaminase (TGase-4) antagonizes the anti-tumour action of MDA-7/IL-24 in prostate cancer", JOURNAL OF TRANSLATIONAL MEDICINE, BIOMED CENTRAL, LONDON, GB, vol. 9, no. 1, 28 April 2011 (2011-04-28), pages 49, XP021100780, ISSN: 1479-5876, DOI: 10.1186/1479-5876-9-49
CHI-MING CHAN ET AL: "Inhibitory Effects of Resveratrol on PDGF-BB-Induced Retinal Pigment Epithelial Cell Migration via PDGFR[beta], PI3K/Akt and MAPK pathways", PLOS ONE, vol. 8, no. 2, 14 February 2013 (2013-02-14), pages e56819, XP055176938, DOI: 10.1371/journal.pone.0056819
VIKTORIA KONYA ET AL: "Endothelial E-type prostanoid 4 receptors promote barrier function and inhibit neutrophil trafficking", JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, vol. 131, no. 2, 1 February 2013 (2013-02-01), pages 532 - 540.e2, XP055105469, ISSN: 0091-6749, DOI: 10.1016/j.jaci.2012.05.008
Attorney, Agent or Firm:
REMILLARD, Jane, E. et al. (One Post Office SquareBoston, MA, US)
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