Title:
ATOPIC DERMATITIS MODEL ANIMAL AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2014/178392
Kind Code:
A1
Abstract:
Provided are a transgenic nonhuman mammal that holds a DNA encoding IL-33 in a state of being expressible specifically in the skin, etc., when fed under specific pathogen free (SPF) conditions, said transgenic nonhuman mammal having, compared with a non-transgenic nonhuman mammal corresponding thereto, one or more characteristics selected from the group consisting of:
(1) spontaneously developing dermatitis;
(2) showing an increase in inflammatory cell count;
(3) showing an increase in total IgE concentration, histamine concentration, cytokine concentration and/or chemokine concentration; and
(4) showing an increase in scratching behavior time.
Inventors:
YAMANISHI KIYOFUMI (JP)
MIZUTANI HITOSHI (JP)
IMAI YASUTOMO (JP)
YOSHIMOTO TOMOHIRO (JP)
NAKANISHI KENJI (JP)
MIZUTANI HITOSHI (JP)
IMAI YASUTOMO (JP)
YOSHIMOTO TOMOHIRO (JP)
NAKANISHI KENJI (JP)
Application Number:
PCT/JP2014/061931
Publication Date:
November 06, 2014
Filing Date:
April 30, 2014
Export Citation:
Assignee:
HYOGO COLLEGE MEDICINE (JP)
UNIV MIE (JP)
UNIV MIE (JP)
International Classes:
A01K67/027; G01N33/15; G01N33/50; C12N15/09
Domestic Patent References:
| WO2001095710A1 | 2001-12-20 |
Other References:
T.SAVINKO ET AL.: "IL-33 and ST2 in Atopic Dermatitis: Expression Profiles and Modulation by Triggering Factors", JOURNAL OF INVESTIGATIVE DERMATOLOGY, vol. 132, no. 5, May 2012 (2012-05-01), pages 1392 - 1400, XP055289945
A.J.HUEBER ET AL.: "IL-33 induces skin inflammation with mast cell and neutrophil activation", EUROPEAN JOURNAL OF IMMUNOLOGY, vol. 41, no. 8, August 2011 (2011-08-01), pages 2229 - 2237, XP055016524
J. KELLER ET AL.: "Transgenic over-expression of interleukin-33 in osteoblasts results in decreased osteoclastogenesis", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 417, no. 1, 6 January 2012 (2012-01-06), pages 217 - 222, XP055016615
Z.XIANG ET AL.: "Over-expression of IL-33 leads to spontaneous pulmonary inflammation in mIL-33 transgenic mice", IMMUNOLOGY LETTERS, vol. 131, no. 2, 2010, pages 159 - 165, XP027083501
D.R.NEILL ET AL.: "Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity", NATURE, vol. 464, no. 7293, 29 April 2010 (2010-04-29), pages 1367 - 1370, XP002590398
Y, IMAI ET AL.: "Skin-specific expression of IL-33 activates group 2 innate lymphoid cells and elicits atopic dermatitis-like inflammation in mice", PNAS, vol. 110, no. 34, 20 August 2013 (2013-08-20), pages 13921 - 13926, XP055289954
GUTERMUTH J ET AL., INT ARCH ALLERGY IMMUNOL, vol. 135, 2004, pages 262 - 276
SHIINA T ET AL., J BIOL CHEM., vol. 279, 2004, pages 55493 - 55498
SAVINKO T ET AL., J INVEST DERMATOL, vol. 132, 2012, pages 1392 - 1400
RANKIN AL ET AL., J IMMUNOL, vol. 184, 2010, pages 1526 - 1535
HUEBER AJ ET AL., EUR J IMMUNOL, vol. 41, 2011, pages 2229 - 2237
EVANS; KAUFMAN, NATURE, vol. 292, 1981, pages 154
M.J. EVANS; M.H. KAUFMAN, NATURE, vol. 292, 1981, pages 154
G.R. MARTIN, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, USA, vol. 78, 1981, pages 7634
T. C. DOETSCHMAN ET AL., JOURNAL OF EMBRYOLOGY AND EXPERIMENTAL MORPHOLOGY, vol. 87, 1985, pages 27
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, USA, vol. 99, no. 4, 2002, pages 2140 - 2145
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, USA, vol. 98, 2001, pages 13090 - 13095
CORREN J, DISCOV MED, vol. 13, 2012, pages 305 - 312
KIEHL P ET AL., BR J DERMATOL., vol. 145, 2001, pages 720 - 729
MATSUDA H ET AL., INT. IMMUNOL, vol. 9, no. 3, 1997, pages 461 - 466
HOGAN ET AL.: "Manipulating the mouse embryo", 1994, COLD SPRING HARBOR LABORATORY PRESS
YASUDA K ET AL., PROC NATL ACAD SCI U S A, vol. 109, 2012, pages 3451 - 62012
See also references of EP 2992759A4
A.J.HUEBER ET AL.: "IL-33 induces skin inflammation with mast cell and neutrophil activation", EUROPEAN JOURNAL OF IMMUNOLOGY, vol. 41, no. 8, August 2011 (2011-08-01), pages 2229 - 2237, XP055016524
J. KELLER ET AL.: "Transgenic over-expression of interleukin-33 in osteoblasts results in decreased osteoclastogenesis", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 417, no. 1, 6 January 2012 (2012-01-06), pages 217 - 222, XP055016615
Z.XIANG ET AL.: "Over-expression of IL-33 leads to spontaneous pulmonary inflammation in mIL-33 transgenic mice", IMMUNOLOGY LETTERS, vol. 131, no. 2, 2010, pages 159 - 165, XP027083501
D.R.NEILL ET AL.: "Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity", NATURE, vol. 464, no. 7293, 29 April 2010 (2010-04-29), pages 1367 - 1370, XP002590398
Y, IMAI ET AL.: "Skin-specific expression of IL-33 activates group 2 innate lymphoid cells and elicits atopic dermatitis-like inflammation in mice", PNAS, vol. 110, no. 34, 20 August 2013 (2013-08-20), pages 13921 - 13926, XP055289954
GUTERMUTH J ET AL., INT ARCH ALLERGY IMMUNOL, vol. 135, 2004, pages 262 - 276
SHIINA T ET AL., J BIOL CHEM., vol. 279, 2004, pages 55493 - 55498
SAVINKO T ET AL., J INVEST DERMATOL, vol. 132, 2012, pages 1392 - 1400
RANKIN AL ET AL., J IMMUNOL, vol. 184, 2010, pages 1526 - 1535
HUEBER AJ ET AL., EUR J IMMUNOL, vol. 41, 2011, pages 2229 - 2237
EVANS; KAUFMAN, NATURE, vol. 292, 1981, pages 154
M.J. EVANS; M.H. KAUFMAN, NATURE, vol. 292, 1981, pages 154
G.R. MARTIN, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, USA, vol. 78, 1981, pages 7634
T. C. DOETSCHMAN ET AL., JOURNAL OF EMBRYOLOGY AND EXPERIMENTAL MORPHOLOGY, vol. 87, 1985, pages 27
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, USA, vol. 99, no. 4, 2002, pages 2140 - 2145
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, USA, vol. 98, 2001, pages 13090 - 13095
CORREN J, DISCOV MED, vol. 13, 2012, pages 305 - 312
KIEHL P ET AL., BR J DERMATOL., vol. 145, 2001, pages 720 - 729
MATSUDA H ET AL., INT. IMMUNOL, vol. 9, no. 3, 1997, pages 461 - 466
HOGAN ET AL.: "Manipulating the mouse embryo", 1994, COLD SPRING HARBOR LABORATORY PRESS
YASUDA K ET AL., PROC NATL ACAD SCI U S A, vol. 109, 2012, pages 3451 - 62012
See also references of EP 2992759A4
Attorney, Agent or Firm:
TAKASHIMA, HAJIME (JP)
Takashima 1 (JP)
Takashima 1 (JP)
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