Title:
AURORA KINASE INHIBITOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/008338
Kind Code:
A1
Abstract:
The present invention relates to a new type of pyridine compound and preparation method and application thereof. Specifically, the present invention relates to the compound represented by formula (1) and a preparation method thereof, and the use of the compound of formula (1) and its pharmaceutically acceptable salts as Aurora Kinase inhibitors in the preparation of an antitumor drug.
Inventors:
XIE YULI (CN)
FAN HOUXING (CN)
FAN HOUXING (CN)
Application Number:
PCT/CN2020/098775
Publication Date:
January 21, 2021
Filing Date:
June 29, 2020
Export Citation:
Assignee:
WIGEN BIOMEDICINE TECH SHANGHAI CO LTD (CN)
International Classes:
A61K31/4545; C07D417/14; A61P35/00; A61P35/02; C07D401/14
Domestic Patent References:
| WO2009104802A1 | 2009-08-27 | |||
| WO2018117267A1 | 2018-06-28 | |||
| WO2016077161A1 | 2016-05-19 |
Foreign References:
| CN107108567A | 2017-08-29 | |||
| CN104159893A | 2014-11-19 | |||
| US20150065479A1 | 2015-03-05 | |||
| CN201910643061A | 2019-07-16 |
Other References:
VASILEVICH, NATALYA I. ET AL.: "General Ser/Thr Kinases Pharmacophore Approach for Selective Kinase Inhibitors Search as Exemplified by Design of Potent and Selective Aurora A Inhibitors", CHEM BIOL DRUG DES, vol. 88, no. 1,, 30 January 2016 (2016-01-30), XP055598572, ISSN: 1747-0285, DOI: 20200715161259X
VASILEVICH, NATALYA I. ET AL.: "Search for Potent and Selective Aurora A Inhibitors Based on General Ser/Thr Kinase Pharmacophore Model", PHARMACEUTICALS, vol. 9, no. 2,, 13 April 2016 (2016-04-13), XP055774024, ISSN: 1424-8247, DOI: 20200715161758X
CANCER METASTASIS REV., vol. 22, 2003, pages 451
NAT. REV. CANCER, vol. 5, 2005, pages 42
MOL. CANCER THER., vol. 8, 2009, pages 2046 - 2056
PROC NATL ACAD SCI USA, vol. 99, no. 24, 2002, pages 15440 - 15445
J. CELL SCI., vol. 120, 2007, pages 2987
J. CLIN. PATHOL., vol. 60, no. 2, 2007, pages 218 - 221
CAREYSUNDBERG: "ADVANCED ORGANIC CHEMISTRY", vol. A, B, 2000, PLENUM
GREENWUTS: "PROTECTIVE GROUPS IN ORGANIC SYNTHESIS", 1999, WILEY
VASILEVICH, NATALYA I. ET AL.: "Search for Potent and Selective Aurora A Inhibitors Based on General Ser/Thr Kinase Pharmacophore Model", PHARMACEUTICALS, vol. 9, no. 2,, 13 April 2016 (2016-04-13), XP055774024, ISSN: 1424-8247, DOI: 20200715161758X
CANCER METASTASIS REV., vol. 22, 2003, pages 451
NAT. REV. CANCER, vol. 5, 2005, pages 42
MOL. CANCER THER., vol. 8, 2009, pages 2046 - 2056
PROC NATL ACAD SCI USA, vol. 99, no. 24, 2002, pages 15440 - 15445
J. CELL SCI., vol. 120, 2007, pages 2987
J. CLIN. PATHOL., vol. 60, no. 2, 2007, pages 218 - 221
CAREYSUNDBERG: "ADVANCED ORGANIC CHEMISTRY", vol. A, B, 2000, PLENUM
GREENWUTS: "PROTECTIVE GROUPS IN ORGANIC SYNTHESIS", 1999, WILEY
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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