Title:
AUTOPHAGY ACTIVATOR
Document Type and Number:
WIPO Patent Application WO/2022/059776
Kind Code:
A1
Abstract:
An autophagy activator according to the present invention comprising an inositol derivative, in which a saccharide is bound to inositol, as an active ingredient, and a composition for autophagy activation that comprises the aforesaid autophagy activator and a pharmaceutically acceptable carrier.
Inventors:
NAKAGAMI YUKO (JP)
Application Number:
PCT/JP2021/034305
Publication Date:
March 24, 2022
Filing Date:
September 17, 2021
Export Citation:
Assignee:
SHOWA DENKO KK (JP)
International Classes:
A61K31/7034; A61K31/665; A61K31/7048; A61P25/28; A61P43/00; A61K8/60
Domestic Patent References:
| WO2018173653A1 | 2018-09-27 | |||
| WO2019045113A1 | 2019-03-07 | |||
| WO2018173653A1 | 2018-09-27 | |||
| WO2016076310A1 | 2016-05-19 | |||
| WO2019045113A1 | 2019-03-07 |
Foreign References:
| JP2006522740A | 2006-10-05 | |||
| JP2018080204A | 2018-05-24 | |||
| JP2019112354A | 2019-07-11 | |||
| JPH05213763A | 1993-08-24 | |||
| JP2003507419A | 2003-02-25 | |||
| JP2020156460A | 2020-10-01 | |||
| JP2018080204A | 2018-05-24 | |||
| JP2018510902W | ||||
| JP2019529514W | ||||
| JPS63196596A | 1988-08-15 | |||
| JPH06298783A | 1994-10-25 | |||
| JPH02279690A | 1990-11-15 | |||
| JPH06345786A | 1994-12-20 | |||
| JPS6265550A | 1987-03-24 | |||
| JPH08134055A | 1996-05-28 | |||
| JPH01228977A | 1989-09-12 | |||
| JPH03139288A | 1991-06-13 | |||
| JPS5944375A | 1984-03-12 | |||
| JPH0914705A | 1997-01-17 | |||
| JP6312333B2 | 2018-04-18 |
Other References:
S. SARKAR, J. E. DAVIES, Z. HUANG, A. TUNNACLIFFE, D. C. RUBINSZTEIN: "Trehalose, a Novel mTOR-independent Autophagy Enhancer, Accelerates the Clearance of Mutant Huntingtin and -Synuclein", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, vol. 282, no. 8, 23 February 2007 (2007-02-23), pages 5641 - 5652, XP055137426, ISSN: 00219258, DOI: 10.1074/jbc.M609532200
YOGENDRA S.RAJAWAT ET AL.: "Aging: Central role for autophagy and the lysosomal degradative system", AGING RESEARCH REVIEWS, vol. 8, 2009, pages 199 - 213, XP026160041, DOI: 10.1016/j.arr.2009.05.001
AARON BARNETT ET AL.: "Autophagy in Aging and Alzheimer's Disease: Pathologic or Protective?", J ALZHEIMERS DIS., vol. 25, no. 3, 2011, pages 385 - 394
MARTA M. LIPINSKI ET AL.: "Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease", PROC NATL ACAD SCI USA., vol. 107, 2010, pages 14164 - 14169, XP002615444, DOI: 10.1073/PNAS.1009485107
XIANGQING LI ET AL.: "Cubeben induces autophagy via PI3K-AKT-mTOR pathway to protect primary neurons against amyloid beta in Alzheimer's disease", CYTOTECHNOLOGY, vol. 71, 2019, pages 679 - 686, XP036796730, DOI: 10.1007/s10616-019-00313-6
KAGEYAMA ET AL.: "Autophagy and Disease", INTERDISCIPLINARY REVIEW, vol. 3, 2014, pages e006
INOMATA ET AL.: "Relationship between autophagy and aging", JOURNAL OF DENTAL SCIENCE, vol. 45, no. 1, 2018, pages 1 - 7
SAKIEKI, NIPPON KAGAKU ZASSI, vol. 79, 1958, pages 733 - 736
JAPANESE PHARMACOPOEIA
JAPANESE NON-PHARMACOPOEIA PHARMACEUTICAL STANDARDS
"Pharmaceutical Excipients Standards", 2013, YAKUJI NIPPO
"Pharmaceutical Excipients Dictionary", 2016, YAKUJI NIPPO
"Handbook of Pharmaceutical Excipients", 2012, PHARMACEUTICAL PRESS
"Standards for Cosmetic Ingredients", 1984, YAKUJI NIPPO
"Supplement to Standards for Non- Standard Cosmetic Ingredients", 1993, YAKUJI NIPPO
"Dictionary of Cosmetic Ingredients", 1991, NIKKO CHEMICALS, INC.
"International Cosmetic Ingredient Dictionary and Handbook", vol. 1-4, 2002
YOGENDRA S.RAJAWAT ET AL.: "Aging: Central role for autophagy and the lysosomal degradative system", AGING RESEARCH REVIEWS, vol. 8, 2009, pages 199 - 213, XP026160041, DOI: 10.1016/j.arr.2009.05.001
AARON BARNETT ET AL.: "Autophagy in Aging and Alzheimer's Disease: Pathologic or Protective?", J ALZHEIMERS DIS., vol. 25, no. 3, 2011, pages 385 - 394
MARTA M. LIPINSKI ET AL.: "Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease", PROC NATL ACAD SCI USA., vol. 107, 2010, pages 14164 - 14169, XP002615444, DOI: 10.1073/PNAS.1009485107
XIANGQING LI ET AL.: "Cubeben induces autophagy via PI3K-AKT-mTOR pathway to protect primary neurons against amyloid beta in Alzheimer's disease", CYTOTECHNOLOGY, vol. 71, 2019, pages 679 - 686, XP036796730, DOI: 10.1007/s10616-019-00313-6
KAGEYAMA ET AL.: "Autophagy and Disease", INTERDISCIPLINARY REVIEW, vol. 3, 2014, pages e006
INOMATA ET AL.: "Relationship between autophagy and aging", JOURNAL OF DENTAL SCIENCE, vol. 45, no. 1, 2018, pages 1 - 7
SAKIEKI, NIPPON KAGAKU ZASSI, vol. 79, 1958, pages 733 - 736
JAPANESE PHARMACOPOEIA
JAPANESE NON-PHARMACOPOEIA PHARMACEUTICAL STANDARDS
"Pharmaceutical Excipients Standards", 2013, YAKUJI NIPPO
"Pharmaceutical Excipients Dictionary", 2016, YAKUJI NIPPO
"Handbook of Pharmaceutical Excipients", 2012, PHARMACEUTICAL PRESS
"Standards for Cosmetic Ingredients", 1984, YAKUJI NIPPO
"Supplement to Standards for Non- Standard Cosmetic Ingredients", 1993, YAKUJI NIPPO
"Dictionary of Cosmetic Ingredients", 1991, NIKKO CHEMICALS, INC.
"International Cosmetic Ingredient Dictionary and Handbook", vol. 1-4, 2002
Attorney, Agent or Firm:
OIKAWA Shu et al. (JP)
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