Title:
AUTOPHAGY ACTIVATOR
Document Type and Number:
WIPO Patent Application WO/2022/059775
Kind Code:
A1
Abstract:
An autophagy activator that comprises methyl hesperidin as an active ingredient, and a composition for autophagy activation that comprises the aforesaid autophagy activator and a pharmaceutically acceptable carrier.
Inventors:
NAKAGAMI YUKO (JP)
Application Number:
PCT/JP2021/034285
Publication Date:
March 24, 2022
Filing Date:
September 17, 2021
Export Citation:
Assignee:
SHOWA DENKO KK (JP)
International Classes:
A61K31/7034; A61K31/665; A61K31/7032; A61K31/7048; A61K48/00; A61P1/04; A61P25/00; A61P25/14; A61P25/16; A61P25/28; A61P35/00
Domestic Patent References:
| WO2014181716A1 | 2014-11-13 | |||
| WO2016076310A1 | 2016-05-19 | |||
| WO2019045113A1 | 2019-03-07 |
Foreign References:
| KR20040065864A | 2004-07-23 | |||
| JP2018058769A | 2018-04-12 | |||
| JP2020125246A | 2020-08-20 | |||
| JP2020156459A | 2020-10-01 | |||
| JP2018080204A | 2018-05-24 | |||
| JP2018510902W | ||||
| JP2019529514W | ||||
| JP6312333B2 | 2018-04-18 | |||
| JPH02279690A | 1990-11-15 | |||
| JPH06345786A | 1994-12-20 | |||
| JPS6265550A | 1987-03-24 | |||
| JPH08134055A | 1996-05-28 | |||
| JPH01228977A | 1989-09-12 | |||
| JPH03139288A | 1991-06-13 | |||
| JPS5944375A | 1984-03-12 | |||
| JPH0914705A | 1997-01-17 | |||
| JPS63196596A | 1988-08-15 | |||
| JPH06298783A | 1994-10-25 |
Other References:
ZHU BIN; YANG CHUN; WU JING; HUA FEI: "Autophagic activation may be involved in the mechanism of hesperidin's therapeutic effects on cognitive impairment", JOURNAL OF NEUROLOGICAL SCIENCES, vol. 351, no. 1, 26 February 2015 (2015-02-26), NL , pages 202 - 203, XP029124948, ISSN: 0022-510X, DOI: 10.1016/j.jns.2015.02.036
SAIPRASAD GOWRIKUMAR, CHITRA PALANIVEL, MANIKANDAN RAMAR, SUDHANDIRAN GANAPASAM: "Hesperidin induces apoptosis and triggers autophagic markers through inhibition of Aurora-A mediated phosphoinositide-3-kinase/Akt/mammalian target of rapamycin and glycogen synthase kinase-3 beta signalling cascades in experimental colon carcinogenesis", EUROPEAN JOURNAL OF CANCER, vol. 50, no. 14, 1 September 2014 (2014-09-01), Amsterdam NL , pages 2489 - 2507, XP055912055, ISSN: 0959-8049, DOI: 10.1016/j.ejca.2014.06.013
RANJITHA C J, MANJUNATHA P MUDAGAL , ASWINI G: "Human Journals Neuroprotective Effect of Hesperidin Methyl Chalcone against Aluminium Chloride Induced Alzheimer's Disease: In-Silico, In- Vitro, and In-Vivo Studies", INTERNATIONAL JOURNAL OF PHARMACY & PHARMACEUTICAL RESEARCH, vol. 19, no. 4, 1 October 2020 (2020-10-01), pages 114 - 136, XP055912063
LIU FU JIA, KAUR PRAMEET, KAROLINA DWI S, SEPRAMANIAM SUGUNAVATHI, ARMUGAM ARUNMOZHIARASI, WONG PETER, JEYASEELAN KANDIAH: "MiR-335 Regulates Hif-1α to Reduce Cell Death in Both Mouse Cell Line and Rat Ischemic Models", PLOS ONE, vol. 10, no. 6, 1 June 2015 (2015-06-01), US , pages 1 - 19, XP055905596, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0128432
YOGENDRA S. RAJAWAT ET AL.: "Aging: Central role for autophagy and the lysosomal degradative system", AGING RESEARCH REVIEWS, vol. 8, 2009, pages 199 - 213, XP026160041, DOI: 10.1016/j.arr.2009.05.001
AARON BARNETT ET AL.: "Autophagy in Aging and Alzheimer's Disease: Pathologic or Protective?", J ALZHEIMERS DIS., vol. 25, no. 3, 2011, pages 385 - 394
MARTA M. LIPINSKI ET AL.: "Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease", PROC NATL ACAD SCI USA., vol. 107, 2010, pages 14164 - 14169, XP002615444, DOI: 10.1073/PNAS.1009485107
XIANGQING LI ET AL.: "Cubeben induces autophagy via PI3K-AKT-mTOR pathway to protect primary neurons against amyloid beta in Alzheimer's disease", CYTOTECHNOLOGY, vol. 71, 2019, pages 679 - 686, XP036796730, DOI: 10.1007/s10616-019-00313-6
KAGEYAMA ET AL.: "Autophagy and Disease", INTERDISCIPLINARY REVIEW, vol. 3, 2014, pages e006
INOMATA ET AL.: "Relationship between autophagy and aging", JOURNAL OF DENTAL SCIENCE, vol. 45, no. 1, 2018, pages 1 - 7
GOWRIKUMAR SAIPRASAD ET AL.: "Hesperidin induces apoptosis and triggers autophagic markers through inhibition of Aurora-A mediated phosphoinositide-3-kinase/Akt/mammalian target of rapamycin and glycogen synthase kinase-3 beta signalling cascades in experimental colon carcinogenesis", EUROPEAN JOURNAL OF CANCER, vol. 50, 2014, pages 2489 - 2507, XP055912055, DOI: 10.1016/j.ejca.2014.06.013
SAKIEKI, NIPPON KAGAKU ZASSI, vol. 79, 1958, pages 733 - 736
JAPANESE PHARMACOPOEIA
"Handbook of Pharmaceutical Excipients", 2012, PHARMACEUTICAL PRESS
JAPANESE NON-PHARMACOPOEIA PHARMACEUTICAL STANDARDS
"Pharmaceutical Excipients Standards", 2013, YAKUJI NIPPO
"Pharmaceutical Excipients Dictionary", 2016, YAKUJI NIPPO
"Standards for Cosmetic Ingredients", 1984, YAKUJI NIPPO
"Supplement to Standards for Non-Standard Cosmetic Ingredients", 1993, PHARMACEUTICAL AFFAIRS BUREAU, MINISTRY OF HEALTH AND WELFARE
"Dictionary of Cosmetic Ingredients", 1991, NIKKO CHEMICALS, INC.
"International Cosmetic Ingredient Dictionary and Handbook", vol. 1-4, 2002, CTFA
SAIPRASAD GOWRIKUMAR, CHITRA PALANIVEL, MANIKANDAN RAMAR, SUDHANDIRAN GANAPASAM: "Hesperidin induces apoptosis and triggers autophagic markers through inhibition of Aurora-A mediated phosphoinositide-3-kinase/Akt/mammalian target of rapamycin and glycogen synthase kinase-3 beta signalling cascades in experimental colon carcinogenesis", EUROPEAN JOURNAL OF CANCER, vol. 50, no. 14, 1 September 2014 (2014-09-01), Amsterdam NL , pages 2489 - 2507, XP055912055, ISSN: 0959-8049, DOI: 10.1016/j.ejca.2014.06.013
RANJITHA C J, MANJUNATHA P MUDAGAL , ASWINI G: "Human Journals Neuroprotective Effect of Hesperidin Methyl Chalcone against Aluminium Chloride Induced Alzheimer's Disease: In-Silico, In- Vitro, and In-Vivo Studies", INTERNATIONAL JOURNAL OF PHARMACY & PHARMACEUTICAL RESEARCH, vol. 19, no. 4, 1 October 2020 (2020-10-01), pages 114 - 136, XP055912063
LIU FU JIA, KAUR PRAMEET, KAROLINA DWI S, SEPRAMANIAM SUGUNAVATHI, ARMUGAM ARUNMOZHIARASI, WONG PETER, JEYASEELAN KANDIAH: "MiR-335 Regulates Hif-1α to Reduce Cell Death in Both Mouse Cell Line and Rat Ischemic Models", PLOS ONE, vol. 10, no. 6, 1 June 2015 (2015-06-01), US , pages 1 - 19, XP055905596, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0128432
YOGENDRA S. RAJAWAT ET AL.: "Aging: Central role for autophagy and the lysosomal degradative system", AGING RESEARCH REVIEWS, vol. 8, 2009, pages 199 - 213, XP026160041, DOI: 10.1016/j.arr.2009.05.001
AARON BARNETT ET AL.: "Autophagy in Aging and Alzheimer's Disease: Pathologic or Protective?", J ALZHEIMERS DIS., vol. 25, no. 3, 2011, pages 385 - 394
MARTA M. LIPINSKI ET AL.: "Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease", PROC NATL ACAD SCI USA., vol. 107, 2010, pages 14164 - 14169, XP002615444, DOI: 10.1073/PNAS.1009485107
XIANGQING LI ET AL.: "Cubeben induces autophagy via PI3K-AKT-mTOR pathway to protect primary neurons against amyloid beta in Alzheimer's disease", CYTOTECHNOLOGY, vol. 71, 2019, pages 679 - 686, XP036796730, DOI: 10.1007/s10616-019-00313-6
KAGEYAMA ET AL.: "Autophagy and Disease", INTERDISCIPLINARY REVIEW, vol. 3, 2014, pages e006
INOMATA ET AL.: "Relationship between autophagy and aging", JOURNAL OF DENTAL SCIENCE, vol. 45, no. 1, 2018, pages 1 - 7
GOWRIKUMAR SAIPRASAD ET AL.: "Hesperidin induces apoptosis and triggers autophagic markers through inhibition of Aurora-A mediated phosphoinositide-3-kinase/Akt/mammalian target of rapamycin and glycogen synthase kinase-3 beta signalling cascades in experimental colon carcinogenesis", EUROPEAN JOURNAL OF CANCER, vol. 50, 2014, pages 2489 - 2507, XP055912055, DOI: 10.1016/j.ejca.2014.06.013
SAKIEKI, NIPPON KAGAKU ZASSI, vol. 79, 1958, pages 733 - 736
JAPANESE PHARMACOPOEIA
"Handbook of Pharmaceutical Excipients", 2012, PHARMACEUTICAL PRESS
JAPANESE NON-PHARMACOPOEIA PHARMACEUTICAL STANDARDS
"Pharmaceutical Excipients Standards", 2013, YAKUJI NIPPO
"Pharmaceutical Excipients Dictionary", 2016, YAKUJI NIPPO
"Standards for Cosmetic Ingredients", 1984, YAKUJI NIPPO
"Supplement to Standards for Non-Standard Cosmetic Ingredients", 1993, PHARMACEUTICAL AFFAIRS BUREAU, MINISTRY OF HEALTH AND WELFARE
"Dictionary of Cosmetic Ingredients", 1991, NIKKO CHEMICALS, INC.
"International Cosmetic Ingredient Dictionary and Handbook", vol. 1-4, 2002, CTFA
Attorney, Agent or Firm:
OIKAWA Shu et al. (JP)
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