AZA-BICYCLIC N-BIARYLAMIDES WITH AFFINITY FOR THE ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR

WIPO Patent Application WO2003078431

A8

1-Azabicycloalkyl carboxylic acid N-bi(hetero)aryl-amides (I) are new. Azabicycloalkyl amides of formula (I), their salts, solvates and solvated salts are new. R1 = aza-bicyclo (m.n.p) alkyl with 7-11 ring atoms (optionally substituted by T); T = 1-6C alkyl; m, n = 2 or 3; p = 1-3; A = direct bond, CH2, CH2CH2 or (CH2)3; E = 5- or 6-membered heteroarylene or phenylene (both optionally substituted by halo, CN, CF3, OCF3 or T; R2 = 5- or 6-membered heteroaryl or phenyl, both optionally substituted by halo, 5- or 6-membered heterocyclyl, CONR4R5, COOR6, NR7R8, NR9COR10, COR13, CN, CF3, OCF3, NO2, T', OT' or ST'; T' = T (optionally substituted by OH, NH2, NHCOR11, OCONHR14, halo or CN); R4-R11, R11, R13, R14 = H, T, phenyl or benzyl; R3 = H or T. An Independent claim is also included for the preparation of (I).

LUITHLE JOACHIM (DE)
BOESS FRANK-GERHARD (DE)
ERB CHRISTINA (DE)
SCHNITZLER KATRIN (DE)
FLESSNER TIMO (DE)
VAN KAMPEN MARJA (DE)
METHFESSEL CHRISTOPH (DE)
HAFNER FRANK-THORSTEN (DE)

PCT/EP2003/002153

November 04, 2004

March 03, 2003

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BAYER HEALTHCARE AG (DE)
LUITHLE JOACHIM (DE)
BOESS FRANK-GERHARD (DE)
ERB CHRISTINA (DE)
SCHNITZLER KATRIN (DE)
FLESSNER TIMO (DE)
VAN KAMPEN MARJA (DE)
METHFESSEL CHRISTOPH (DE)
HAFNER FRANK-THORSTEN (DE)

C07D453/04; A61K31/439; A61K31/5377; A61P9/10; A61P25/00; A61P25/04; A61P25/14; A61P25/16; A61P25/18; A61P25/28; A61P31/18; A61P43/00; C07D453/02; (IPC1-7): C07D453/02; A61K31/439; A61P25/28

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