Title:
AZANORBORNANE DERIVATIVES
Document Type and Number:
WIPO Patent Application WO1993000330
Kind Code:
A3
Abstract:
PCT No. PCT/US92/04697 Sec. 371 Date Dec. 14, 1993 Sec. 102(e) Date Dec. 14, 1993 PCT Filed Jun. 11, 1992 PCT Pub. No. WO93/00330 PCT Pub. Date Jan. 7, 1993The present invention relates to novel azanorbornane derivatives having the formula , and to novel intermediates used in their synthesis. The compounds having formula I are useful in the treatment of inflammatory and central nervous system disorders, as well as other disorders.
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Inventors:
O'NEILL BRIAN THOMAS (US)
Application Number:
PCT/US1992/004697
Publication Date:
March 04, 1993
Filing Date:
June 11, 1992
Export Citation:
Assignee:
PFIZER (US)
International Classes:
A61K31/4025; A61K31/40; A61K31/41; A61K31/42; A61K31/425; A61K31/44; A61K31/4427; A61K31/443; A61K31/4433; A61K31/47; A61P25/00; A61P29/00; A61P43/00; C07B57/00; C07D207/09; C07D207/14; C07D401/04; C07D401/12; C07D401/14; C07D403/04; C07D403/12; C07D403/14; C07D405/04; C07D405/12; C07D405/14; C07D409/04; C07D409/12; C07D409/14; C07D413/04; C07D413/12; C07D413/14; C07D417/04; C07D417/12; C07D417/14; C07D487/08; (IPC1-7): C07D/
Domestic Patent References:
| WO1990005729A1 | 1990-05-31 | |||
| WO1991009844A1 | 1991-07-11 | |||
| WO1992001688A1 | 1992-02-06 | |||
| WO1992006079A1 | 1992-04-16 |
Foreign References:
| EP0362941A2 | 1990-04-11 |
Other References:
ACTA CHEM. SCAND. SER. B vol. B35, no. 7, 1981, pages 3557 - 70; P. THORBEK ET AL.: 'Synthese and proton NMR spectroscopic investigations of some pyrrolidinecarboxylic acids designed as potential glial GABA uptake inhibitors' compounds of formulae 17 to 20
J. MED. CHEM. vol. 18, no. 6, 1975, pages 587 - 593; E.J. WARAWA ET AL.: 'Quinuclidine Chemistry. 4. Diuretic properties of cis-3-amino-2-benzhydrylquinuclidine' compounds of general formula III
J. MED. CHEM. vol. 17, no. 5, 1974, pages 497 - 501; E.J. WARAWA ET AL.: 'Quinuclidine Chemistry. 2. Synthesis and Antiinflammatory Properties of 2-Substituted Benzhydryl-3-quinuclidinols' compounds 2, 3, 6 and 7 compounds of general formulae III & IV
J. MED. CHEM. vol. 18, no. 1, 1975, pages 71 - 74; E.J. WARAWA ET AL.: 'Quinuclidine Chemistry. 3. 1beta-cis-2-(4'-cis-2-(4'-Chlorobenzhydryl)-3-qu inuclidinol, a New Central Nervous System Stimulant. Importance of the Benzhydryl Configuration'
J. MED. CHEM. vol. 18, no. 6, 1975, pages 587 - 593; E.J. WARAWA ET AL.: 'Quinuclidine Chemistry. 4. Diuretic properties of cis-3-amino-2-benzhydrylquinuclidine' compounds of general formula III
J. MED. CHEM. vol. 17, no. 5, 1974, pages 497 - 501; E.J. WARAWA ET AL.: 'Quinuclidine Chemistry. 2. Synthesis and Antiinflammatory Properties of 2-Substituted Benzhydryl-3-quinuclidinols' compounds 2, 3, 6 and 7 compounds of general formulae III & IV
J. MED. CHEM. vol. 18, no. 1, 1975, pages 71 - 74; E.J. WARAWA ET AL.: 'Quinuclidine Chemistry. 3. 1beta-cis-2-(4'-cis-2-(4'-Chlorobenzhydryl)-3-qu inuclidinol, a New Central Nervous System Stimulant. Importance of the Benzhydryl Configuration'
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