BASE MODIFICATION ANALYSIS USING ELECTRICAL SIGNALS

WIPO Patent Application WO/2022/218290

A1

Systems and methods for determining base modifications using electrical signals and other data is described herein. Embodiments can make use of features derived from electrical signals related to sequencing, such as those acquired from using a nanopore (116), that are affected by the various base modifications, as well as an identity of nucleotides in a window around a target position whose methylation status is determined. Other features may include a vector of statistical values of a segment of the electrical signal corresponding to the nucleotide and a statistical value of the electrical signal in a window in a region of the nucleic acid molecule. The detected base modifications can be used for additional analysis of a biological sample.

JP2009529876	Methods and Means for Sequencing Nucleic Acids
WO/2004/023142	ANALYTICAL PLATFORM AND DETECTION METHOD WITH ANALYTES WHICH ARE TO BE DETECTED IN A SAMPLE IN THE FORM OF IMMOBILIZED SPECIFIC BINDING PARTNERS
WO/2006/065051	METHOD OF FABRICATING BIOCHIP

LO YUK-MING DENNIS (CN)
CHIU ROSSA WAI KWUN (CN)
CHAN KWAN CHEE (CN)
JIANG PEIYONG (CN)
CHENG SUK HANG (CN)
DENG JIAEN (CN)

PCT/CN2022/086260

October 20, 2022

April 12, 2022

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UNIV HONG KONG CHINESE (CN)

C12Q1/68

US20210047679A1	2021-02-18
CN107849607A	2018-03-27
CN104662165A	2015-05-27
US20020197639A1	2002-12-26
US20110014607A1	2011-01-20
US20100028877A1	2010-02-04

INSIGHT INTELLECTUAL PROPERTY LIMITED (CN)

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