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Title:
TROPOMYOSIN RECEPTOR KINASE (TRK) DEGRADATION COMPOUNDS AND METHODS OF USE
Document Type and Number:
WIPO Patent Application WO/2022/218289
Kind Code:
A1
Abstract:
This disclosure relates to heterobifunctional compounds (e.g., bi-functional small molecule compounds), compositions comprising one or more of the heterobifunctional compounds, and to methods of use the heterobifunctional compounds for the treatment of certain disease in a subject in need thereof. The disclosure also relates to methods for identifying such heterobifunctional compounds.

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Inventors:
LIU JING (CN)
WANG JIALIANG (CN)
HAN XIAORAN (CN)
YANG TING (CN)
Application Number:
PCT/CN2022/086258
Publication Date:
October 20, 2022
Filing Date:
April 12, 2022
Export Citation:
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Assignee:
CULLGEN SHANGHAI INC (CN)
International Classes:
C07D403/14; A61K31/506; A61P35/00; C07D401/14; C07D403/12; C07D405/14; C07D409/14; C07D413/14; C07D417/14; C07D487/04
Domestic Patent References:
WO2020038415A12020-02-27
Foreign References:
CN106459013A2017-02-22
CN104781255A2015-07-15
CN103649076A2014-03-19
EP3412663A12018-12-12
JP2019026646A2019-02-21
Attorney, Agent or Firm:
XU&PARTNERS, LLC. (CN)
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