Repellents and deterrents against insects, mites and ticks have the task of deterring harm- ful or troublesome arthropods from contacting, stinging, sucking or biting areas that are attractive to them, such as the skin of animals and humans, by means of prior treatment of these areas with such compositions.

In the context of the present invention, arthropods are understood to be in particular insects, mites and ticks. These include insects of the order: Lepidoptera, Coleoptera, Homoptera, Heteroptera, Diptera, Thysanoptera, Orthoptera, Anoplura, Siphonaptera, Mallophaga, Thysanura, Isoptera, Psocoptera and Hymenoptera. However, the vermin which may be mentioned in particular are those which trouble humans or animals and carry pathogens, for example flies such as Musca domestica, Musca vetustissima, Musca autumnalis, Fannia canicularis, Sarcophaga camaria, Lucilia cuprina, Hypoderma bovis, Hypoderma lineatum, Chrysomyia chloropyga, Dermatobia hominis, Cochliomyia hominivorax, Gasterophilus intestinalis, Oestrus ovis, Stomoxys calcitrans, Haematobia irritans and midges (Nemato- cera), such as Culicidae, Simuliidae, Psychodidae, but also blood-sucking vermin, for example fleas, such as Ctenocephalides felis and Ctenocephalides canis (cat and dog fleas), Xenopsylla cheopis, Pulex irritans, Dermatophilus penetrans, lice, such as Damalina ovis, Pediculus humanis, biting flies and horse-flies (Tabanidae), Haematopota spp. such as Haematopota pluvialis, Tabanidea spp. such as Tabanus nigrovittatus, Chrysopsinae spp. such as Ch/ysops caecutiens, tsetse flies, such as species of Glossinia, biting insects, parti- cularly cockroaches, such as Blatella germanica, Blatta orientalis, Periplaneta americana, mites, such as Dermanyssus gallinae, Sarcoptes scabiei, Psoroptes ovis and Psorergates spp. and last but not least ticks. The latter belong to the order Acarina. Known representa- tives of ticks are, for example, Boophilus, Amblyomma, Anocentor, Dermacentor, Haema- physalis, Hyalomma, Ixodes, Rhipicentor, Margaropus, Rhipicephalus, Argas, Otobius and Omithodoros and the like, which preferably infest warm-blooded animals inciuding farm animals, such as cattle, pigs, sheep and goats, poultry such as chickens, turkeys and geese, fur-bearing animals such as mink, foxes, chinchillas, rabbits and the like, as well as domestic animals such as cats and dogs, but also humans.

Ticks are responsible world-wide for the transmission and spread of many human and animal diseases. Because of their economic influence, the most important ticks are Boophi- lus, Rhipicephalus, lxodes, Hyalomma, Amblyomma and Dermacentor. They are carriers of bacterial, viral, rickettsial and protozoal diseases and cause tick-paralysis and tick-toxicosis.

Even a single tick can cause paralysis whereby its saliva penetrates into the host animal during ingestion. Diseases caused by ticks are usually transmitted by ticks, which infest several host animals. Such diseases, for example babesiosis, anaplasmosis, theileriasis and heart water disease, are responsible for the death or impairment of a large number of domestic and farm animals in the entire world. In many countries of temperate climate, Ixodide ticks transmit the agent of the chronically harmful Lyme's disease from wild animals to humans. Apart from the transmission of disease, the ticks are responsible for great economic losses in livestock production. Losses are not confined to the death of the host animals, but also include damage to the pelts, loss of growth, a reduction in milk production and reduced value of the meat. Although the harmful effects of a tick infestation on animals have been known for years, and enormous progress has been made using tick-control programmes, until now no completely satisfactory methods of controlling or eliminating these parasites have been found, and in addition, ticks have often developed resistance to chemical active ingredients.

The infestation of fleas on domestic animals and pets likewise represents for the owner a problem which has not yet been satisfactorily resolved. Owing to their complex life cycle, none of the known methods for the control of fleas is completely satisfactory, especially as most known methods are basically directed towards the control of adult fleas in the pelt, and leave completely untouched the different juvenile stages of the fleas, which exist not only in the pelt of the animal, but also on the floor, in carpets, in the bedding of the animal, on chairs, in the garden and all other places with which the infested animal comes into contact.

Flea treatment is usually expensive and has to be continued over long periods of time.

Success usually depends on treating not only the infested animal, e. g. the dog or cat, but at the same time all the locations which the infested animal frequents.

Such a complicated procedure is unnecessary with the present benzazole derivatives. For a particular advantage of the benzazole derivatives under discussion is that they are extreme- ly effective and at the same time of very low toxicity both for the target parasites and for the warm-blooded animals. This is because their activity is based not on the death of the target parasite, but on the parrying defence thereof (as a repellent or as a deterrent), before it sting, bites or in any other way harms the host organism. The presence of the benzazole derivatives being discussed here appears to disturb the parasites in such a way that they suddenly leave the treated environment without biting or stinging, or even do not infest a treated host animal at all. An addition advantage lies in the long-ter action, e. g. compa- red with DEET (N, N-diethyl-m-toluamide), which although very effective, volatilizes rather rapidly and is therefore often difficult to apply. Usage of the present active ingredients is also pleasant because they are almost odourless.

Numerous active ingredients have already been proposed as repellents/deterrents (e. g. K.

H. Buchei in Chemie der Pflanzenschutz-und Schadlingsbekampfungsmittel; R. Wegler, Vol. 1, Springer Verlag Berlin, Heidelberg, New York, 1970, pp. 487 ff).

3-Methylbenzoic acid diethylamine (DEET), dimethyl phthalate and 2-ethylhexane-1,3-diol are particularly well-known and have been in use for a long time. Of these, DEET has become particularly important in practice [e. g. R. K. Kocher, R. S. Dixit, C. I. Somaya, Ind. J.

Med. Res., 62,1 (1974)].

In addition, urea derivatives and carboxamides having insect-repelling activity are known (e. g. EP-A-22 653; DE-A-27 56 360; US 3 624 204; US 4 356 180; EP-B1-0 467 045).

A considerable disadvantage of the known repellents/deterrents is partly their relatively short duration of activity (usually only a few hours).

Now, new benzazole derivatives of formula I have been found, wherein R, and R2 are the same or different and signify hydrogen, hydroxyl, amino, halogen, C,-C6- <BR> <BR> <BR> alkyl, halogen-C,-C6-alkyl, C2-C6-alkenyl, halogen-C2-C6-alkenyl, C3-C6-cycloalkyl, halogen- C3-C6-cycloalkyl, C,-C6-alkoxy, halogen-C-C6-alkoxy, unsubstituted phenyl or phenyl which is optionally substituted by halogen or C,-C6-alkyl; nitro, cyano, isothiocyanato, carboxy, C,- C6-alkoxycarbonyl, halogen-C,-C6-alkoxycarbonyl, C,-C6-alkylcarbamido, which is optionally substituted by phenyl or by unsubstituted or halogen-substituted phenoxy; PhNH (CO) NH, C,-C6-alkylsulphonyl, halogen-C,-C6-alkylsulphonyl, unsubstituted or optionally halogen- substituted benzoyl; unsubstituted or optionally halogen-substituted phenylthionyl or phenylsulphonyl; R3 and R4, independently of one another, are hydrogen, Ri, R2 or together are a CH=CH-CH=CH-bridge; XisNR5, 0orS; R5 is hydrogen or C,-C6-alkyl; Y is N, CR6 or C=O; R6 is hydrogen, hydroxyl, C,-C6-alkyl, C,-C6-alkylcarbonyl, C,-C6-alkoxy, cyano, 2-di (C,-C6- alkyl) aminoethenyl, (C,-C6-alkyl) NHC (=S) NHCH2, phenyl, thiazolyl, phenylamino, whereby the phenyl group is unsubstituted or optionally substituted by C,-C6-alkoxy; C,-C6-alkyl- carbamido, C,-C6-alkoxycarbamido, guanidyl, amino, hydroxyl-Cz-C6-alkylamino or phenyl- sulphonylamino, whereby the phenyl group is unsubstituted or optionally substituted by C,- C6-alkyl; Z is N or CR7; and R7 is hydrogen or C,-C6-alkyl, which are eminently suitable for long-ter repellenbdeterrent action against ectoparasites on warm-blooded animals. The repellent/deterrent action is considerably better than that of the repellents/deterrents known from the prior art. The expression ectoparasite as used here has the normal meaning according to the prior art and includes fleas, ticks, lice, mosquitos, horse flies, tsetse flies and other biting flies, especially ticks.

The general terms used hereinbefore and hereinafter, if not defined to the contrary, have the meanings given below.

Halogen-as a group per se and as structural element of other groups and compounds such as halogen-alkyl, halogen-cycloalkyl and halogen-alkenyl-is fluorine, chlorine, bromine or iodine, especially fluorine, chlorine or bromine, in particular fluorine or chlorine.

Halogen-substituted carbon-containing groups, such as halogen-alkyl, halogen-cycloalkyl, halogen-alkenyl, halogen-alkoxy or halogen-alkoxycarbonyl, may be partially halogenated or perhalogenated, whereby in the case of multiple halogenation, the halogen substituents may be identical or different. Examples of halogen-alkyl-as a group per se and as structu- ral element of other groups and compounds such as halogen-cycloalkyl, halogen-alkenyl, halogen-alkoxy or halogen-alkoxycarbonyl,-are methyl which is mono-to trisubstituted by fluorine, chlorine and/or bromine, such as CHF2 or CF3; ethyl which is mono-to pentasubsti- tuted by fluorine, chlorine and/or bromine, such as CH2CF3, CF2CF3, CF2CC13, CF2CHC12, CF2CHF2, CF2CFC12, CF2CHBr2, CF2CHCIF, CF2CHBrF or CCIFCHCIF; propyl or isopropyl, mono-to heptasubstituted by fluorine, chlorine and/or bromine, such as CH2CHBrCH2Br, CF2CHFCF3, CH2CF2CF3 or CH (CF3) 2; and butyl or one of its isomers, mono-to nonasubsti- tuted by fluorine, chlorine and/or bromine, such as CF (CF3) CHFCF3 or CH2 (CF2) 2CF3; pentyl or one of its isomers substituted one to eleven times by fluorine, chlorine and/or bromine, such as CF (CF3) (CHF) 2CF3 or CH2 (CF2) 3CF3; and hexyl or one of its isomers substituted one to thirteen times by fluorine, chlorine and/or bromine, such as (CH2) 4CHBrCH2Br, CF2 (CHF) 4CF3, CH2 (CF2) 4CF3 or C (CF3) 2 (CHF) 2CF3.

If not defined to the contrary, carbon-containing groups and compounds contain 1 to 6, preferably 1 to 4, especially 1 or 2, carbon atoms.

C3-C6-cycloalkyl is cyclopropyl, cyclobutyl, cyclopentyl or cyclohexyl.

Alkyl-as a group per se and as structural element of other groups and compounds such as alkoxy, halogen-alkyl or halogen-alkoxy-is, in each case with due consideration of the specific number of carbon atoms in the group or compound in question, either straight- chained or branched, and is methyl, ethyl, propyl, isopropyl, butyl, isobutyl, sec.-butyl or tert.-butyl or pentyl, hexyl, or one of the respective isomers thereof. Preferred alkyl groups R, are C,-C3-alkyl groups, especially C,-C2-alkyl groups.

Alkenyl contains one or more, preferably no more than two, unsaturated carbon-carbon bonds. Examples which may be mentioned are vinyl, allyl, methallyl, prop-1-en-1-yl, 2- methyl-prop-1-en-1-yl and but-2-en-1-yl.

The compounds which are preferred within the scope of the invention are (1) compounds of formula 1, wherein R, and R2 are identical or different and are hydrogen, hydroxyl, amino, halogen, d-Ce-atky !, halogen-C,-C6-alkyl, C,-C6-alkoxy, nitro, cyano, isothiocyanato, carboxy, C,-C6-alkoxy- carbonyl, C,-C6-alkylcarbamido which is optionally substituted by phenyl or by unsubstituted or halogen-substituted phenoxy; PhNH (CO) NH, C,-C6-alkylsulphonyl, halogen-C,-C6-alkyl- sulphonyl, benzoyl, phenylthionyl or phenylsulphonyl; (2) compounds of formula 1, wherein X is NH, O or S; (3) compounds of formula 1, wherein Y is CR6 or C=O; and R6 is hydrogen, C,-C6-alkyl, C,-C6-alkylcarbonyl, cyano, 2-di (C,-C6-alkyl) aminoethenyl, phenyl, thiazolyl, phenylamino, whereby the phenyl group is unsubstituted or optionally substituted by C,-C6-alkoxy; C,-C6-alkylcarbamido, C1-C6-alkoxycarbamido, guanidiyl, amino, hydroxy-C2-C6-alkylamino or phenylsulphonylamino, whereby the phenyl group is unsubstituted or optionally substituted by C,-C6-alkyl; (4) compounds of formula 1, wherein Z is N; (5) compounds of formula I, wherein R, and R2 are identical or different and are hydrogen, hydroxyl, amino, halogen, C,-C2-alkyl, halogen-C,-C2-alkyl, C,-C2-alkoxy, nitro, cyano, isothiocyanato, carboxy, ethoxycarbonyl, C,-C6-alkylcarbamido which is optionally substituted by phenyl or by unsubstituted or halogen-substituted phenoxy; PhNH (CO) NH, C1-C6-alkylsulphonyl, halogen-C,-C6-alkyl- sulphonyl, benzol, phenylthionyl or phenylsulphonyl; R3 and R4 are H or together are a CH=CH-CH=CH-bridge; X is NH, NCOCH3, O or S; Y is CR6 or C=O; R6 is hydrogen, C,-C6-alkyl, C,-C6-alkylcarbonyl, cyano, 2-di (C,-C6-alkyl) aminoethenyl, phenyl, thiazolyl, phenylamino, whereby the phenyl group is unsubstituted or optionally substituted by C,-C6-alkoxy; C,-C6-alkylcarbamido, C,-C6-alkoxycarbamido, guanidiyl, amino, hydroxy-C2-C6-alkylamino or phenylsulphonylamino, whereby the phenyl group is unsubstituted or optionally substituted by C1-C6-alkyl; and Z is N; (6) compounds of formula 1, wherein R, and R2 are identical or different and are hydrogen, amino, halogen, C,-C2-alkoxy, isothiocyanato, C,-C6-alkylsulphonyl, halogen-C,-C6-alkylsulphonyl or benzoyl; R3 and R4 are H or together are a CH=CH-CH=CH-bridge; X is S; Y is CR6 or C=O; R6 is C,-C6-alkyl, C,-C6-alkylcarbonyl or 2-di (C,-C6-alkyl) aminoethenyl; and Z is N; The following compounds of formula I are those which are preferred within the scope of the invention: 2-ethyl-5-methoxy-6-isothiocyanatobenzothiazole, 2-t-butyl-5-methoxy-6-isothiocyanatobenzothiazole, <BR> <BR> <BR> 5-amino-2-methylbenzothiazole,<BR> <BR> <BR> <BR> <BR> 2-(2-dimethylaminoethenyl)-benzothiazole, 2-propionylbenzothiazole, 4-chloro-2-methylbenzothiazole, 5,6-dimethoxy-2-methylbenzothiazole, 2-methylnaphtho [1,2-d] thiazole, <BR> <BR> <BR> 6-methoxy-2-methylbenzothiazole,<BR> <BR> <BR> <BR> <BR> 5-trifluoromethylsulphonyl-2-methylbenzothiazole, 6-benzoyl-(2H)-benzoxazolone(2H)-benzoxazolone and 3-acetyl-6-fluoro-(2H)-benzoxazolone;(2H)-benzoxazolone especially 5-amino-2-methylbenzothiazole and 5,6-dimethoxy-2-methylbenzothiazole.

The invention inclues all the compounds of formula 1, provided that they are new.

General processes for the preparation of compounds of formula I are known. It has been found that benzazole derivatives of formula I are obtained whereby, for example, a) in order to produce compounds of formula 1, wherein Y and Z are N, and X, Ri, Rs, Rs and R4 have the significances given in formula 1, a compound of formula which is known or may be produced by known processes, and wherein X, Z, Ri, R2, R3 and R4 have the significances given in formula 1, is reacted with NaNO2 in an aqueous solution containing a mineral acid, or b) in order to produce compounds of formula 1, wherein Y is N, Z is CR7, and X, Ri, Rs, Rs and R4 have the significances given in formula 1, a compound of formula which is known or may be produced by known processes, and wherein Ri, R2, R3, R4, Rg and R7 have the significances given in formula 1, is reacted with NaN02 in an aqueous solution containing a mineral acid, and the resultant intermediate, if necessary after interim isolation, is reduced with a reduction agent such as Snob, sodium dithionite or zinc dust in water, or <BR> <BR> <BR> <BR> <BR> <BR> <BR> c) in order to produce compounds of formula 1, wherein Y is CR6, Z is N, and X, R"R2, R3 and R4 have the significances given in formula 1, a compound of formula 11, wherein X, Z, <BR> <BR> <BR> <BR> Ri, R2, R3 and R4 have the significances given in formula 1, is reacted with a compound of formula QCOR6, wherein Q is hydroxyl, C,-C2-alkoxy or halogen, and R6 has the significance given in formula 1, or <BR> <BR> <BR> <BR> <BR> <BR> d) in order to produce compounds of formula 1, wherein Y is CR6, Z is CR7, and X, Ri, R2, R3 and R4 have the significances given in formula 1, a compound of formula which is known or may be produced by known processes, and wherein X, R"R2, R3 and R4 have the significances given in formula 1, is reacted with a compound of formula QC (R6) C (=O) R7, wherein Q is hydroxyl or halogen, and R6 and R7 have the significances given in formula 1, or e) in order to produce compounds of formula 1, wherein Y is COH, Z is N, and X, Ri, Rz, Rs and R4 have the significances given in formula 1, a compound of formula 11 is reacted with phosgene or with a carbonic acid dialkylester, or f) in order to produce compounds of formula 1, wherein X is O or S, Y is N, Z is CR7 and Ri, R2, R3 and R4 have the significances given in formula 1, it is reacted with CINH2, and if desired, a compound of formula I which is obtainable by this process or in another way, or a tautomer thereof, may be converted into another compound of formula I or a tautomer thereof, a mixture of isomers which is obtainable by this process is separated and the desired isomer isolated.

In the process of the present invention, the starting materials and intermediates used are preferably those which lead to the compounds I that were initially portrayed as especially valable.

Starting materials and intermediates, which are new and are used according to the invention for the preparation of compounds 1, as well as their usage and process for the preparation thereof, similarly form an object of the invention.

Although the present benzazole derivatives can of course be mixed with other substances having the same sphere of activity or with parasiticides or with other activity-improving substances to achieve further improved or longer-lasting action, and then applied, in contrast to many compounds of the prior art, this is totally unnecessary, as they already combine all the advantageous properties.

If the parasite is not only to be kept at bay, but also killed, of course this can be achieved by adding appropriate insecticides and/or acaricides. In practice, however, this is unnecessary in most cases.

The present benzazole derivatives are preferably used in diluted form. Normally, they are brought to the final application form by using appropriate formulation excipients, whereby the preparations of the formulations to be applied are produced in known manner by mixing or diluting the active ingredients according to the invention with solvents (e. g. xylene, chlorobenzenes, paraffins, methanol, isopropanol, water), carrier materials (e. g. kaolins, clay, talc, chalk, highly dispersed silicic acid, silicates), emulsifiers (e. g. polyoxyethylene- fatty acid esters, polyoxyethylene fat alcohol ether, alkyl sulphonates, aryl sulphonates) and dispersing agents (e. g. lignin, waste sulphite lye, methyl cellulose).

Since they are in many instances applied to warm-blooded animals and of course come into contact with the skin, suitable formulation excipients are the excipients and administration forms that are known in cosmetics. They may be administered in the form of solutions, emulsions, ointments, creams, pastes, powders, sprays, etc. The preparations generally contain between 0.1 and 95 % by weight of active ingredient, preferably between 0.5 and 90%.

For administration to farm animals or pets, the so-called'pour-on'or'spot-on'formulations are especially suitable; these liquid or semi-liquid formulations have the advantage that they only have to be applied to a small area of the pelt or plumage, and, thanks to the proportion of spreading oils or other spreading additives, they disperse by themselves over the whole pelt or plumage, without further support, and become active over the whole area.

Of course, inanimate objects, for example human clothing or dog and cat baskets, may be treated with said formulations and thus protected from parasite infestation.

In order to control cockroaches, their locus, usually cracks in the walls, furniture, etc., can be sprayed or powdered.

For the application on humans, a pleasant-smelling essence, e. g. a perfume, can be added to make the application more attractive.

The following examples of preparation and usage of the active ingredients according to the invention serve to illustrate the invention without restricting it.

In particular, preferred formulations are made up as follows: Formulation Example 1 A vermin-deterring composition in the form of a lotion for the application to the skin is prepared by mixing 30 parts of one of the active ingredients according to the invention, 1.5 parts of perfume and 68.5 parts of isopropanol, whereby the latter may be replaced by ethanol.

Formulation Example 2 A vermin-deterring composition in the form of an aerosol for spraying onto the skin is prepared by formulating 50% active ingredient solution, consisting of 30 parts of one of the active ingredients according to the invention, 1.5 parts of perfume and 68.5 parts of isopropanol, with 50% Frigen 11/12 (a halogenated hydrocarbon) as propellant gas in an aerosol can.

Formulation Example 3 A vermin-deterring composition in the form of an aerosol for spraying onto the skin is prepared by formulating 40% active ingredient solution, consisting of 20 parts of one of the active ingredients according to the invention, 1 part of perfume, 79 parts of isopropanol, with 60% propane/butane (in a ratio of 15: 85) as propellant gas in an aerosol can.

Biological Tests Arena test method for testing vermin-repellent substances This method is carried out in titre plates having 6 wells with a cross-section of 5 cm each, using a computer-supported video system. Each well of the titre plate is lined with a circular filter paper or another suitable carrier material. The substance of formula I to be tested is dissolve in methanol, acetonitrile or another suitable solvent, with ultrasound treatment and heating being employed for poorly-soluble substances. In an amount of 1 to 100 mg/cm2, the dissolve test substance is placed in the centre of the filter paper on a quad- rant or circular area of ca. 2.4 cm2 radius. 4 of the 6 wells are filled with different test sub- stances or with the same test substance in different dilutions (e. g. 1,3.2,5,10 and 20 mg/cm2). The 5th well is treated with DEET (N, N-diethyl-m-toluamide) as standard substan- ce. The 6th well is filled with the pure solvent and serves as a control. 60 to 100 larvae or 25 to 50 nymphs or 10 to 25 adults of the parasite to be tested, e. g. ticks, are added to each filter paper, and the system is covered with a pane of glass and positioned under a video camera.

At intervals of 5 seconds, the video camera takes individual pictures of all 6 wells. For a qualitative evaluation, these images are observed in a time-laps as a continuous film, optically following the movements of the parasites on the filter paper and comparing them with the movements in the control well no. 6 or with the standard in the 5th well. A qualita- tive observation is thus made as to whether the test parasites move evenly over the whole surface of the filter paper and ignore the test substance, or whether and over what period they avoid the treated zone, and what influence the dilution of the test substance has on the behaviour of the test parasites. In this way, neutral and repellent substances are deter- mined. At the same time, the duration of activity of the test substance is determined and compared with that of the standard. By plotting all the images for each individual well over one another, different areas of density are obtained. This represents the frequency at which the parasites visit certain places. This frequency is evaluated statistically and thus quanti- tatively by the Willcoxon method in a comparison with the control and with the standard.

Example A: In vitro test; test animal: Boophilus microplus Biarra (larvae) The test is carried out as described above, with ca. 60 to 100 larvae being added per well.

An evaluation of the video images shows that the compounds according to the invention display marked repellent action. In particular, the compounds 5-amino-2-methylbenzo- thiazole and 5,6-dimethoxy-2-methylbenzothiazole are notable for an almost complete repellent/deterrent action, which lasts considerably longer than that of DEET.

Example B: In vitro test; test animal: Amblyomma hebraeum or variegatum (nymphs) The test is carried out as described above, with ca. 25 nymphs being added per well. An evaluation of the video images shows that the compounds according to the invention display marked repellent action. In particular, the compounds 5-amino-2-methylbenzo- thiazole and 5,6-dimethoxy-2-methylbenzothiazole are notable for an almost complete repellent/deterrent action, which lasts considerably longer than that of DEET.

Example C: In vitro test: test animal: Rhipicephalus sanguines (nymphs) The test is carried out analogously to example B, with ca. 40 to 50 nymphs. An evaluation of the video images shows that the compounds according to the invention display marked repellent action. In particular, the compounds 5-amino-2-methylbenzothiazole and 5,6- dimethoxy-2-methylbenzothiazole are notable for an almost complete repellent/deterrent action, which lasts considerably longer than that of DEET.

In analogous test set-ups, the same test substances are tested for their attractant activity to various species of fly, such as Musca domestica. It is shown that the substances mentioned above display strong repellent action even with these tested models.