Title:
BENZENE COMPOUNDS
Document Type and Number:
WIPO Patent Application WO/2005/108370
Kind Code:
A1
Abstract:
It is intended to provide benzene compounds represented by the following formulae and analogs thereof which exert an ACC activity inhibitory effect and are efficacious in treating hyperlipemia, fatty liver, impaired glucose tolerance, diabetes, diabetic complications (diabetic peripheral neuropathy, diabetic nephropathy, diabetic retinopathy and diabetic great vessel), hypertension and arteriosclerosis.
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Inventors:
SUZUKI NOBUYASU (JP)
NIHEI YUKIO (JP)
ICHINOSE HIDEHIRO (JP)
TANAKA HIDEYUKI (JP)
YASA NORIKO (JP)
HATANAKA TOSHIHIRO (JP)
MASUZAWA YOUKO (JP)
NAKANISHI EIJI (JP)
KONDO NOBUO (JP)
NIHEI YUKIO (JP)
ICHINOSE HIDEHIRO (JP)
TANAKA HIDEYUKI (JP)
YASA NORIKO (JP)
HATANAKA TOSHIHIRO (JP)
MASUZAWA YOUKO (JP)
NAKANISHI EIJI (JP)
KONDO NOBUO (JP)
Application Number:
PCT/JP2005/007392
Publication Date:
November 17, 2005
Filing Date:
April 18, 2005
Export Citation:
Assignee:
AJINOMOTO KK (JP)
SUZUKI NOBUYASU (JP)
NIHEI YUKIO (JP)
ICHINOSE HIDEHIRO (JP)
TANAKA HIDEYUKI (JP)
YASA NORIKO (JP)
HATANAKA TOSHIHIRO (JP)
MASUZAWA YOUKO (JP)
NAKANISHI EIJI (JP)
KONDO NOBUO (JP)
SUZUKI NOBUYASU (JP)
NIHEI YUKIO (JP)
ICHINOSE HIDEHIRO (JP)
TANAKA HIDEYUKI (JP)
YASA NORIKO (JP)
HATANAKA TOSHIHIRO (JP)
MASUZAWA YOUKO (JP)
NAKANISHI EIJI (JP)
KONDO NOBUO (JP)
International Classes:
A61K31/167; A61K31/18; A61K31/192; A61K31/194; A61K31/198; A61K31/216; A61K31/341; A61K31/381; A61K31/402; A61K31/4035; A61K31/4245; A61K31/4402; A61K31/4409; A61K31/4439; A61K31/445; A61K31/455; A61K31/47; A61K31/4709; A61K31/473; A61K31/496; A61K31/501; A61K31/502; A61K31/5377; A61K31/551; A61K45/00; A61P1/16; A61P3/06; A61P3/10; A61P9/00; A61P9/10; A61P9/12; A61P13/12; A61P25/02; A61P27/02; C07C233/66; C07C275/30; C07C311/16; C07C311/21; C07C311/51; C07D207/06; C07D207/16; C07D207/26; C07D207/40; C07D207/452; C07D209/44; C07D209/48; C07D211/60; C07D213/36; C07D213/81; C07D213/82; C07D215/20; C07D215/48; C07D221/14; C07D235/18; C07D271/06; C07D277/28; C07D277/30; C07D307/52; C07D333/24; C07D401/06; C07D401/10; C07D401/12; C07D405/04; C07D405/12; C07D409/12; C07D413/04; C07D413/06; C07D413/12; C07D413/14; C07D417/04; C07D417/10; C07D417/12; C07D417/14; C07F9/653; C07D207/44; (IPC1-7): C07D215/20; A61K31/167; A61K31/18; A61K31/192; A61K31/194; A61K31/198; A61K31/216; A61K31/341; A61K31/381; A61K31/402; A61K31/4035; A61K31/4245; A61K31/4402; A61K31/4409; A61K31/4439; A61K31/445; A61K31/455; A61K31/47; A61K31/4709; A61K31/473; A61K31/496; A61K31/501; A61K31/502; A61K31/5377; A61K31/551; A61K45/00; A61P1/16; A61P3/06; A61P3/10; A61P9/00; A61P9/10; A61P9/12; A61P13/12; A61P25/02; A61P27/02; C07C233/66; C07C311/16; C07C311/21; C07C311/51; C07D207/06; C07D207/16; C07D207/26; C07D207/40; C07D207/452; C07D209/44; C07D209/48; C07D211/60; C07D213/36; C07D213/81; C07D213/82; C07D215/48; C07D221/14; C07D271/06; C07D277/28; C07D307/52; C07D333/24; C07D401/06; C07D401/10; C07D401/12; C07D405/04; C07D405/12; C07D409/12; C07D413/06; C07D413/12; C07D417/04; C07D417/10; C07D417/12; C07D417/14
Domestic Patent References:
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Other References:
BARASHKOV N.N.: "Synthesis and spectral-luminescence properties of aromatic polyamides and polyesters with chromophores in the polymer main chain", SYNTHETIC METALS, vol. 75, no. 3, 1995, pages 241 - 248
FERLES M.: "Quinoline and isoquinoline derivatives. VI. Reactions of 3-quinoline carbonitrile and 6-quinolinecarbonitrile with methylmagnesium iodide and phenymagnesium bromide", COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATION, vol. 44, no. 9, 1979, pages 2672 - 2676
LEVERT K.L.: "A Biotin Analog Inhibits Acetyl-CoA Carboxylase Activity and Adipogenesis", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 277, no. 19, 2002, pages 16347 - 16350
BJANCHI A.: "Acetyl-CoA carboxylase in Reuber hepatoma cells: variation in enzyme activity, insulin regulation and cellular lipid content", JOURNAL OF CELLILAR BIOCHEMISTRY, vol. 48, no. 1, 1992, pages 86 - 97
FERLES M.: "Quinoline and isoquinoline derivatives. VI. Reactions of 3-quinoline carbonitrile and 6-quinolinecarbonitrile with methylmagnesium iodide and phenymagnesium bromide", COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATION, vol. 44, no. 9, 1979, pages 2672 - 2676
LEVERT K.L.: "A Biotin Analog Inhibits Acetyl-CoA Carboxylase Activity and Adipogenesis", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 277, no. 19, 2002, pages 16347 - 16350
BJANCHI A.: "Acetyl-CoA carboxylase in Reuber hepatoma cells: variation in enzyme activity, insulin regulation and cellular lipid content", JOURNAL OF CELLILAR BIOCHEMISTRY, vol. 48, no. 1, 1992, pages 86 - 97
Attorney, Agent or Firm:
Kumakura, Yoshio (Shin-Tokyo Bldg. 3-1, Marunouchi 3-chome, Chiyoda-k, Tokyo 55, JP)
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