Title:
BENZODIHYDROPYRAN COMPOUND TARGETING ALDO-KETO REDUCTASE 1C3
Document Type and Number:
WIPO Patent Application WO/2021/068952
Kind Code:
A1
Abstract:
A structurally novel benzodihydropyran compound targeting AKR1C3 enzyme (aldo-keto reductase 1C3). In particular, disclosed is a compound represented by formula (II) or a pharmaceutically acceptable salt or isomer thereof.
Inventors:
CAI ZHE (CN)
SUN FEI (CN)
DING CHARLES Z (CN)
CHEN SHUHUI (CN)
SUN FEI (CN)
DING CHARLES Z (CN)
CHEN SHUHUI (CN)
Application Number:
PCT/CN2020/120281
Publication Date:
April 15, 2021
Filing Date:
October 12, 2020
Export Citation:
Assignee:
MEDSHINE DISCOVERY INC (CN)
International Classes:
C07D311/74; A61K31/04; A61K31/06; A61K31/664; A61P35/00
Domestic Patent References:
| WO2016145092A1 | 2016-09-15 |
Foreign References:
| CN108136214A | 2018-06-08 |
Other References:
RIZNER, T.L. ; SMUC, T. ; RUPREHT, R. ; SINKOVEC, J. ; PENNING, T.M.: "AKR1C1 and AKR1C3 may determine progesterone and estrogen ratios in endometrial cancer", MOLECULAR AND CELLULAR ENDOCRINOLOGY., ELSEVIER IRELAND LTD, IE, vol. 248, no. 1-2, 27 March 2006 (2006-03-27), IE, pages 126 - 135, XP027882666, ISSN: 0303-7207
ADENIJI, A. O. ET AL.: "AKR1C3 as a Target in Castrate Resistant Prostate Cancer.", THE JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY., vol. 137, 6 June 2013 (2013-06-06), XP028757798, DOI: 10.1016/j.jsbmb.2013.05.012
EVANS KATHRYN, DUAN JIANXIN, PRITCHARD TARA, JONES CONNOR D., MCDERMOTT LISA, GU ZHAOHUI, TOSCAN CARA E., EL-ZEIN NARIMANNE, MAYOH: "OBI-3424, a Novel AKR1C3-Activated Prodrug, Exhibits Potent Efficacy against Preclinical Models of T-ALL", CLINICAL CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, vol. 25, no. 14, 15 July 2019 (2019-07-15), US, pages 4493 - 4503, XP055800824, ISSN: 1078-0432, DOI: 10.1158/1078-0432.CCR-19-0551
ADENIJI, A. O. ET AL.: "AKR1C3 as a Target in Castrate Resistant Prostate Cancer.", THE JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY., vol. 137, 6 June 2013 (2013-06-06), XP028757798, DOI: 10.1016/j.jsbmb.2013.05.012
EVANS KATHRYN, DUAN JIANXIN, PRITCHARD TARA, JONES CONNOR D., MCDERMOTT LISA, GU ZHAOHUI, TOSCAN CARA E., EL-ZEIN NARIMANNE, MAYOH: "OBI-3424, a Novel AKR1C3-Activated Prodrug, Exhibits Potent Efficacy against Preclinical Models of T-ALL", CLINICAL CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, vol. 25, no. 14, 15 July 2019 (2019-07-15), US, pages 4493 - 4503, XP055800824, ISSN: 1078-0432, DOI: 10.1158/1078-0432.CCR-19-0551
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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