Title:
BENZOSELENOPHENE-BASED COMPOUND, PHARMACEUTICAL COMPOSITION CONTAINING SAME, AND ANTIBODY-DRUG CONJUGATE
Document Type and Number:
WIPO Patent Application WO/2021/153984
Kind Code:
A1
Abstract:
The present application relates to a benzoselenophene-based compound, a method for preparing the benzoselenophene-based compound, a pharmaceutical composition comprising the benzoselenophene-based compound, and an antibody-drug conjugate.
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Inventors:
LIM DONGYEOL (KR)
KIM MIN CHEOL (KR)
MHETRE AMOL (KR)
NAM DO-HYUN (KR)
KIM MIN CHEOL (KR)
MHETRE AMOL (KR)
NAM DO-HYUN (KR)
Application Number:
PCT/KR2021/001082
Publication Date:
August 05, 2021
Filing Date:
January 27, 2021
Export Citation:
Assignee:
AIMED BIO INC (KR)
International Classes:
C07D421/06; A61K31/28; A61K47/68; A61P9/10; A61P35/00
Domestic Patent References:
| WO2007087684A1 | 2007-08-09 |
Foreign References:
| KR20170041562A | 2017-04-17 | |||
| KR20130034638A | 2013-04-05 | |||
| US4975278A | 1990-12-04 |
Other References:
MHETRE AMOL B., SREEDHAR EPPAKAYALA, DUBEY RASHMI, SABLE GANESH A., LEE HANGEUN, YANG HEEKYOUNG, LEE KYOUNGMIN, NAM DO-HYUN, LIM D: "Synthesis and biological evaluation of potent benzoselenophene and heteroaromatic analogues of (S)-1-(chloromethyl)-8-methoxy-2,3-dihydro-1H-benzo[e]indol-5-ol (seco-MCBI)", RSC ADVANCES, vol. 9, no. 50, 1 January 2019 (2019-01-01), GB, pages 29023 - 29036, XP009529411, ISSN: 2046-2069, DOI: 10.1039/C9RA04749B
AMOL B. MHETRE, HANGEUN LEE, HEEKYOUNG YANG, KYOUNGMIN LEE, DO-HYUN NAM, DONGYEOL LIM: "Synthesis and anticancer activity of benzoselenophene and heteroaromatic derivatives of 1,2,9,9a-tetrahydrocyclopropa[c]benzo[e]indol-4-one (CBI)", ORGANIC & BIOMOLECULAR CHEMISTRY, ROYAL SOCIETY OF CHEMISTRY, vol. 15, no. 5, 1 January 2017 (2017-01-01), pages 1198 - 1208, XP055410403, ISSN: 1477-0520, DOI: 10.1039/C6OB02729F
CANCER CELL, vol. 3, 2003, pages 207 - 212
TRAIL ET AL., CANCER IMMUNOL. IMMUNOTHER., vol. 52, 2003, pages 328 - 337
SYRIGOSEPENETOS, ANTICANCER RESEARCH, vol. 19, 1999, pages 605 - 614
NICULESCU-DUVAZSPRINGER, ADV. DRUG DEL. REV., vol. 26, 1997, pages 151 - 172
AMOL B. MHETRE, HANGEUN LEE, HEEKYOUNG YANG, KYOUNGMIN LEE, DO-HYUN NAM, DONGYEOL LIM: "Synthesis and anticancer activity of benzoselenophene and heteroaromatic derivatives of 1,2,9,9a-tetrahydrocyclopropa[c]benzo[e]indol-4-one (CBI)", ORGANIC & BIOMOLECULAR CHEMISTRY, ROYAL SOCIETY OF CHEMISTRY, vol. 15, no. 5, 1 January 2017 (2017-01-01), pages 1198 - 1208, XP055410403, ISSN: 1477-0520, DOI: 10.1039/C6OB02729F
CANCER CELL, vol. 3, 2003, pages 207 - 212
TRAIL ET AL., CANCER IMMUNOL. IMMUNOTHER., vol. 52, 2003, pages 328 - 337
SYRIGOSEPENETOS, ANTICANCER RESEARCH, vol. 19, 1999, pages 605 - 614
NICULESCU-DUVAZSPRINGER, ADV. DRUG DEL. REV., vol. 26, 1997, pages 151 - 172
Attorney, Agent or Firm:
MAPS INTELLECTUAL PROPERTY LAW FIRM (KR)
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