Title:
BENZOTHIAZINONE DERIVATIVE BASED ON ALKYNYL LINKING ARM, PREPARATION METHOD THEREFOR, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/065182
Kind Code:
A1
Abstract:
Disclosed are a benzothiazinone derivative based on an alkynyl linking arm, a preparation method therefor, and a use thereof. The present invention is an inventive improvement on the position of a side chain connected to the skeleton of benzothiazinone, and a new benzothiazinone derivative is obtained. In addition to having excellent antibacterial properties, compared with existing benzothiazinone derivatives, the benzothiazinone derivative based on an alkynyl linking arm of the present invention has significantly excellent pharmacokinetic effects in vivo.
Inventors:
QIAO CHUNHUA (CN)
WU XIAOMEI (CN)
WU XIAOMEI (CN)
Application Number:
PCT/CN2021/125101
Publication Date:
April 27, 2023
Filing Date:
October 20, 2021
Export Citation:
Assignee:
UNIV SOOCHOW (CN)
International Classes:
A61K31/5415; C07D279/08; A61P31/06; C07D417/12
Foreign References:
| US20150353572A1 | 2015-12-10 | |||
| CN111269197A | 2020-06-12 | |||
| CN113121521A | 2021-07-16 | |||
| CN101809009A | 2010-08-18 | |||
| CN110204546A | 2019-09-06 |
Other References:
FAN DONGGUANG, WANG BIN, STELITANO GIOVANNI, SAVKOVÁ KARIN, SHI RUI, HUSZÁR STANISLAV, HAN QUANQUAN, MIKUŠOVÁ KATARÍNA, CHIARELLI : "Structural and Activity Relationships of 6-Sulfonyl-8-Nitrobenzothiazinones as Antitubercular Agents", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 64, no. 19, 14 October 2021 (2021-10-14), US , pages 14526 - 14539, XP093057740, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.1c01049
Attorney, Agent or Firm:
SUZHOU CREATOR PATENT AND TRADEMARK AGENCY, LTD (CN)
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