Title:
BENZOTRIAZOLE COMPOUND
Document Type and Number:
WIPO Patent Application WO/2023/210741
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a medicine capable of treating and/or preventing a disease associated with oxidative stress through the inhibition of a protein-protein interaction between Keap1 and Nrf2 to activate Nrf2. The present invention relates to a compound represented by general formula (1): [wherein each symbol is as described in the description] or a pharmaceutically acceptable salt thereof. The present invention also relates to a medicine for preventing and/or treating a disease associated with oxidative stress, in which the disease is selected from the group consisting of chronic kidney disease, non-alcoholic fatty liver disease, chronic obstructive pulmonary disease, radiation-induced skin damages, radiation-induced mucosal damages, heart failure, pulmonary arterial hypertension, Parkinson's disease, Friedreich's ataxia, multiple sclerosis, age-related macular degeneration, retinitis pigmentosa and glaucoma, and the medicine contains the compound.
Inventors:
OGURA YOSHIHIRO (JP)
TAKANO RIEKO (JP)
KAWAI JUNYA (JP)
FUJIMOTO TEPPEI (JP)
INUI MASAHARU (JP)
OFUKU MASAFUMI (JP)
MIYAZAKI MASAKI (JP)
FUJII MASAYA (JP)
ISHII KEN (JP)
YOKOZEKI WAKANA (JP)
OTAKE KAZUYA (JP)
TAKASHIMA SHUNSUKE (JP)
ANDO MASAFUMI (JP)
TAKANO RIEKO (JP)
KAWAI JUNYA (JP)
FUJIMOTO TEPPEI (JP)
INUI MASAHARU (JP)
OFUKU MASAFUMI (JP)
MIYAZAKI MASAKI (JP)
FUJII MASAYA (JP)
ISHII KEN (JP)
YOKOZEKI WAKANA (JP)
OTAKE KAZUYA (JP)
TAKASHIMA SHUNSUKE (JP)
ANDO MASAFUMI (JP)
Application Number:
PCT/JP2023/016629
Publication Date:
November 02, 2023
Filing Date:
April 27, 2023
Export Citation:
Assignee:
DAIICHI SANKYO CO LTD (JP)
KYOTO PHARMA IND (JP)
KYOTO PHARMA IND (JP)
International Classes:
C07D409/06; A61K31/4192; A61K31/4353; A61K31/553; A61P1/16; A61P3/10; A61P9/00; A61P9/12; A61P11/06; A61P13/12; A61P17/00; A61P17/06; A61P19/02; A61P25/00; A61P25/14; A61P25/28; A61P27/02; A61P27/06; A61P27/12; A61P37/02; A61P43/00; C07D417/10; C07D419/10; C07D419/14; C07D498/04; C07D513/04; C07D515/04; C07D515/10; C07D515/20; C07D519/00
Domestic Patent References:
| WO2021002473A1 | 2021-01-07 | |||
| WO2019224667A1 | 2019-11-28 | |||
| WO2018181345A1 | 2018-10-04 | |||
| WO2020241853A1 | 2020-12-03 | |||
| WO2020210229A1 | 2020-10-15 | |||
| WO2020018788A1 | 2020-01-23 | |||
| WO2018109648A1 | 2018-06-21 | |||
| WO2018109647A1 | 2018-06-21 | |||
| WO2016203401A1 | 2016-12-22 | |||
| WO2016203400A1 | 2016-12-22 |
Foreign References:
| JP2022520442A | 2022-03-30 | |||
| JP2021535118A | 2021-12-16 | |||
| JP2020502123A | 2020-01-23 | |||
| JP2018517731A | 2018-07-05 | |||
| JP2017503786A | 2017-02-02 |
Attorney, Agent or Firm:
KAMADA, Mitsunori et al. (JP)
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