Title:
BENZOTHIOPHENE COMPOUND
Document Type and Number:
WIPO Patent Application WO/2023/210740
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a medicinal drug that can treat and/or prevent diseases linked to oxidative stress, by inhibiting the protein-protein interaction between Keap1 and Nrf2 to activate Nrf2. The present invention pertains to a compound represented by general formula (1) [in the formula, the respective symbols are as described in the description] or a pharmaceutically acceptable salt thereof. In addition, the present invention also pertains to a medicinal drug that contains the compound and that is for treating and/or preventing a disease that is linked to oxidative stress and that is selected from the group consisting of chronic kidney disease, nonalcoholic steatohepatitis, chronic obstructive pulmonary disease, radiation dermatitis, radiation mucous membrane disorder, heart failure, pulmonary arterial hypertension, Parkinson's disease, Friedreich's ataxia, multiple sclerosis, age-related macular degeneration, retinitis pigmentosa, and glaucoma.
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Inventors:
OGURA YOSHIHIRO (JP)
FUJIMOTO TEPPEI (JP)
INUI MASAHARU (JP)
TAKANO RIEKO (JP)
OFUKU MASAFUMI (JP)
KAWAI JUNYA (JP)
MIYAZAKI MASAKI (JP)
YOSHITOMI TOMOMI (JP)
EDO NAOKO (JP)
OTAKE KAZUYA (JP)
TAKASHIMA SHUNSUKE (JP)
ANDO MASAFUMI (JP)
FUJIMOTO TEPPEI (JP)
INUI MASAHARU (JP)
TAKANO RIEKO (JP)
OFUKU MASAFUMI (JP)
KAWAI JUNYA (JP)
MIYAZAKI MASAKI (JP)
YOSHITOMI TOMOMI (JP)
EDO NAOKO (JP)
OTAKE KAZUYA (JP)
TAKASHIMA SHUNSUKE (JP)
ANDO MASAFUMI (JP)
Application Number:
PCT/JP2023/016628
Publication Date:
November 02, 2023
Filing Date:
April 27, 2023
Export Citation:
Assignee:
DAIICHI SANKYO CO LTD (JP)
KYOTO PHARMA IND (JP)
KYOTO PHARMA IND (JP)
International Classes:
C07D471/04; A61K31/55; A61K31/553; A61P1/04; A61P1/16; A61P3/10; A61P7/10; A61P9/00; A61P9/04; A61P9/10; A61P9/12; A61P11/00; A61P11/06; A61P11/14; A61P13/12; A61P17/00; A61P17/06; A61P19/02; A61P21/02; A61P25/00; A61P25/14; A61P25/16; A61P25/28; A61P27/02; A61P27/06; A61P27/12; A61P27/14; A61P29/00; A61P37/02; A61P37/06; A61P37/08; A61P39/02; A61P39/06; A61P43/00; C07D498/04; C07D519/00
Domestic Patent References:
| WO2020241853A1 | 2020-12-03 |
Foreign References:
| JP2022520442A | 2022-03-30 | |||
| JP2020502160A | 2020-01-23 | |||
| JP2020502136A | 2020-01-23 | |||
| JP2020502123A | 2020-01-23 | |||
| JP2018517731A | 2018-07-05 | |||
| JPS6038376A | 1985-02-27 |
Attorney, Agent or Firm:
KAMADA, Mitsunori et al. (JP)
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