Title:
BENZOTRIAZOLE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2020/241853
Kind Code:
A1
Abstract:
The present invention provides: a compound having a Keap1-inhibitory effect; and a pharmaceutical composition containing the same. Specifically, the present invention provides: a compound represented by general formula (1) [in the formula, symbols have meanings as described in the specification.], or a pharmaceutically acceptable salt thereof; and a pharmaceutical composition containing the same.
Inventors:
KOMORI KEN-ICHI (JP)
NISHIYAMA HAYATO (JP)
KINOSHITA NAOYA (JP)
WADA YUKINORI (JP)
MORISHITA KOUSUKE (JP)
NINOMIYA AKISHI (JP)
SHIRAISHI YUUSUKE (JP)
ONUMA KAZUHIRO (JP)
OGI SAYAKA (JP)
KAWADA HIROYOSHI (JP)
KIMURA TOMIO (JP)
NISHIYAMA HAYATO (JP)
KINOSHITA NAOYA (JP)
WADA YUKINORI (JP)
MORISHITA KOUSUKE (JP)
NINOMIYA AKISHI (JP)
SHIRAISHI YUUSUKE (JP)
ONUMA KAZUHIRO (JP)
OGI SAYAKA (JP)
KAWADA HIROYOSHI (JP)
KIMURA TOMIO (JP)
Application Number:
PCT/JP2020/021426
Publication Date:
December 03, 2020
Filing Date:
May 29, 2020
Export Citation:
Assignee:
UBE INDUSTRIES (JP)
International Classes:
A61P13/12; A61K31/553; A61P43/00; C07D413/10; C07D498/04
Domestic Patent References:
| WO2016202253A1 | 2016-12-22 | |||
| WO2018109646A1 | 2018-06-21 | |||
| WO2020041169A2 | 2020-02-27 | |||
| WO2019116231A1 | 2019-06-20 | |||
| WO2015092713A1 | 2015-06-25 | |||
| WO2016202253A1 | 2016-12-22 | |||
| WO2016203400A1 | 2016-12-22 | |||
| WO2016203401A1 | 2016-12-22 | |||
| WO2017060854A1 | 2017-04-13 | |||
| WO2017060855A1 | 2017-04-13 | |||
| WO2018104766A1 | 2018-06-14 | |||
| WO2018109641A1 | 2018-06-21 | |||
| WO2018109642A1 | 2018-06-21 | |||
| WO2018109643A1 | 2018-06-21 | |||
| WO2018109646A1 | 2018-06-21 | |||
| WO2018109647A1 | 2018-06-21 | |||
| WO2018109648A1 | 2018-06-21 | |||
| WO2018109649A1 | 2018-06-21 | |||
| WO2018181345A1 | 2018-10-04 | |||
| WO2019224667A1 | 2019-11-28 | |||
| WO2020041169A2 | 2020-02-27 |
Other References:
TOM D. HEIGHTMAN, JAMES F. CALLAHAN, ELISABETTA CHIARPARIN, JOSEPH E. COYLE, CHARLOTTE GRIFFITHS-JONES, AMI S. LAKDAWALA, RACHEL M: "Structure-activity and structure-conformation relationships of aryl propionic acid inhibitors of the Kelch-like ECH- Associated Protein 1/Nuclear Factor Erythroid 2- Related Factor 2 (KEAP1/NRF2) protein-protein interaction", JOURNAL OF MEDICINAL CHEMISTRY, vol. 62, 2019, pages 4683 - 4702, XP055768030
BBA MOLECULAR CELL RESEARCH, vol. 1865, 2018, pages 721 - 733
AMERICAN JOURNAL OF NEPHROLOGY, vol. 47, 2018, pages 40 - 47
MOLECULAR PHARMACOLOGY, vol. 84, 2013, pages 62 - 70
SCIENTIFIC REPORTS, vol. 6, 2016, pages 26585
THE JOURNAL OF PHARMACOLOGY AND EXPERIMANTAL THERAPEUTICS, vol. 363, 2017, pages 114 - 125
MOLECULAR CANCER THERAPEUTICS, vol. 13, no. 12, 2014, pages 2968 - 2977
PROCEEDING OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 113, no. 17, 2016, pages 4777 - 4782
PLOS ONE, vol. 3, no. 10, 2008, pages e3367
KIDNEY INTERNATIONAL, vol. 84, 2013, pages 1090 - 1095
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2013, pages 104308
BRAIN RESEARCH, vol. 1446, 2012, pages 109 - 118
PLOS ONE, vol. 4, no. 1, pages e4253
INVESTIGATIVE OPHTHALMOLOGY VISUAL SCIENCE, vol. 53, no. 9, 2012, pages 5806 - 5813
GENES AND DEVELOPMENT, vol. 24, 2010, pages 1045 - 1058
JOURNAL OF CLINICAL INVESTIGATION, vol. 124, no. 2, 2014, pages 730 - 741
FREE RADICAL BIOLOGY AND MEDICINE, vol. 63, 2013, pages 264 - 273
JOURNAL OF MEDICINAL CHEMISTRY, vol. 59, 2016, pages 3991 - 4006
JOURNAL OF MEDICINAL CHEMISTRY, vol. 62, 2019, pages 4683 - 4702
T. W. GREENE ET AL.: "Protective Groups in Organic Synthesis", JOHN WILEY SONS
BBA MOLECULAR CELL RESEARCH, vol. 1865, 2018, pages 721 - 733
AMERICAN JOURNAL OF NEPHROLOGY, vol. 47, 2018, pages 40 - 47
MOLECULAR PHARMACOLOGY, vol. 84, 2013, pages 62 - 70
SCIENTIFIC REPORTS, vol. 6, 2016, pages 26585
THE JOURNAL OF PHARMACOLOGY AND EXPERIMANTAL THERAPEUTICS, vol. 363, 2017, pages 114 - 125
MOLECULAR CANCER THERAPEUTICS, vol. 13, no. 12, 2014, pages 2968 - 2977
PROCEEDING OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 113, no. 17, 2016, pages 4777 - 4782
PLOS ONE, vol. 3, no. 10, 2008, pages e3367
KIDNEY INTERNATIONAL, vol. 84, 2013, pages 1090 - 1095
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2013, pages 104308
BRAIN RESEARCH, vol. 1446, 2012, pages 109 - 118
PLOS ONE, vol. 4, no. 1, pages e4253
INVESTIGATIVE OPHTHALMOLOGY VISUAL SCIENCE, vol. 53, no. 9, 2012, pages 5806 - 5813
GENES AND DEVELOPMENT, vol. 24, 2010, pages 1045 - 1058
JOURNAL OF CLINICAL INVESTIGATION, vol. 124, no. 2, 2014, pages 730 - 741
FREE RADICAL BIOLOGY AND MEDICINE, vol. 63, 2013, pages 264 - 273
JOURNAL OF MEDICINAL CHEMISTRY, vol. 59, 2016, pages 3991 - 4006
JOURNAL OF MEDICINAL CHEMISTRY, vol. 62, 2019, pages 4683 - 4702
T. W. GREENE ET AL.: "Protective Groups in Organic Synthesis", JOHN WILEY SONS
Attorney, Agent or Firm:
YAMAO, Norihito et al. (JP)
Download PDF: