Title:
BENZYL COMPOUND
Document Type and Number:
WIPO Patent Application WO/2017/038650
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a protecting group with which separation and purification after reactions can be easily implemented, without solidification or insolubilization occurring, by improving the solubility of compounds having protected functional groups in organic solvents. Provided is a benzyl compound represented by general formula (1) (in the formula, X1 indicates -CH2OR14 (where R14 indicates a hydrogen atom, a halogenocarbonyl group or an active ester-type protecting group), -CH2NHR15 (where, R15 indicates a hydrogen atom, a linear or branched alkyl group having 1 to 6 carbon atoms, or an aralkyl group), a halogenomethyl group, a methyl azide group, a formyl group, or an oxime; at least one of R1, R2, R3, R4, and R5 indicate a group represented by formula (2), and the remainder indicate a hydrogen atom, a halogen atom, an alkyl group having 1 to 4 carbon atoms or an alkoxy group having 1 to 4 carbon atoms; R6 indicates a linear or branched alkylene group having 1 to 16 carbon atoms; X2 indicates O or CONR16 (where R16 indicates a hydrogen atom or an alkyl group having 1 to 4 carbon atoms); and A indicates a group represented by formula (3), (4), (5), (6), (7), (8), (9), (10), (11), (12) or (13)).
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Inventors:
YANO SHINYA (JP)
WAKASUGI YUKI (JP)
IWANAGA YOSUKE (JP)
WAKASUGI YUKI (JP)
IWANAGA YOSUKE (JP)
Application Number:
PCT/JP2016/074888
Publication Date:
March 09, 2017
Filing Date:
August 25, 2016
Export Citation:
Assignee:
SEKISUI MEDICAL CO LTD (JP)
International Classes:
C07F7/18; C07B51/00; C07K1/06
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Other References:
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AHMED DJELLAL ET AL.: "Synthesis of S-benzyl thioethers of propylboronic acids", PHOSPHORUS, SULFUR AND SILICON AND THE RELATED ELEMENTS, vol. 179, no. 6, 2004, pages 1123 - 1129, XP009509274
HSUAN-CHIH CHU ET AL.: "Novel Reversible Chemosensory Material Based on Conjugated Side- Chain Polymer Containing Fluorescent Pyridyl Receptor Pendants", JOURNAL OF PHYSICAL CHEMISTRY B, vol. 115, no. 28, 2011, pages 8845 - 8852, XP055516415
DHARMPAL S. DODD ET AL.: "Synthesis of partially non-peptidic neurotensin mimetics", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 4, no. 10, 1994, pages 1241 - 6, XP026608965, DOI: doi:10.1016/S0960-894X(01)80338-3
SOLOMON M. KIMANI ET AL.: "Multihydroxyl End Functional Polyethylenes: Synthesis, Bulk and Interfacial Properties of Polymer Surfactants", MACROMOLECULES, vol. 47, no. 6, 2014, pages 2062 - 2071, XP055516420
XAVIER ELIAS ET AL.: "Hybrid-Bridged Silsesquioxane as Recyclable Metathesis Catalyst Derived from a Bis-Silylated Hoveyda- Type Ligand", ADVANCED SYNTHESIS & CATALYSIS, vol. 348, no. 6, 2006, pages 751 - 762, XP009120748, DOI: doi:10.1002/adsc.200505447
SARAH PICAUD ET AL.: "RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 110, no. 49, 2013, pages 19754 - 19759, XP002737220, DOI: doi:10.1073/pnas.1310658110
See also references of EP 3342777A4
AHMED DJELLAL ET AL.: "Synthesis of S-benzyl thioethers of propylboronic acids", PHOSPHORUS, SULFUR AND SILICON AND THE RELATED ELEMENTS, vol. 179, no. 6, 2004, pages 1123 - 1129, XP009509274
HSUAN-CHIH CHU ET AL.: "Novel Reversible Chemosensory Material Based on Conjugated Side- Chain Polymer Containing Fluorescent Pyridyl Receptor Pendants", JOURNAL OF PHYSICAL CHEMISTRY B, vol. 115, no. 28, 2011, pages 8845 - 8852, XP055516415
DHARMPAL S. DODD ET AL.: "Synthesis of partially non-peptidic neurotensin mimetics", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 4, no. 10, 1994, pages 1241 - 6, XP026608965, DOI: doi:10.1016/S0960-894X(01)80338-3
SOLOMON M. KIMANI ET AL.: "Multihydroxyl End Functional Polyethylenes: Synthesis, Bulk and Interfacial Properties of Polymer Surfactants", MACROMOLECULES, vol. 47, no. 6, 2014, pages 2062 - 2071, XP055516420
XAVIER ELIAS ET AL.: "Hybrid-Bridged Silsesquioxane as Recyclable Metathesis Catalyst Derived from a Bis-Silylated Hoveyda- Type Ligand", ADVANCED SYNTHESIS & CATALYSIS, vol. 348, no. 6, 2006, pages 751 - 762, XP009120748, DOI: doi:10.1002/adsc.200505447
SARAH PICAUD ET AL.: "RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 110, no. 49, 2013, pages 19754 - 19759, XP002737220, DOI: doi:10.1073/pnas.1310658110
See also references of EP 3342777A4
Attorney, Agent or Firm:
THE PATENT CORPORATE BODY ARUGA PATENT OFFICE (JP)
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