Title:
BETA-PEPTIDES
Document Type and Number:
WIPO Patent Application WO2006078274
Kind Code:
A3
Abstract:
ß-peptide regions of polypeptides can serve as structural mimics of a-helices in wild type proteins. Because a-helices of one protein often bind to a target protein in a biological pathway, a polypeptide that contains a helical ß-peptide region can be used to disrupt this type of protein-protein binding. As a result, polypeptides that contain a helical ß-peptide region can be used to treat conditions involving this type of protein protein binding, such as viral infections and cell proliferation.
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Inventors:
SCHEPARTZ-SHRADER ALANNA S (US)
KRITZER JOSHUA A (US)
HART SCOTT A (US)
STEPHENS OLEN M (US)
KRITZER JOSHUA A (US)
HART SCOTT A (US)
STEPHENS OLEN M (US)
Application Number:
PCT/US2005/013570
Publication Date:
December 14, 2006
Filing Date:
April 21, 2005
Export Citation:
Assignee:
UNIV YALE (US)
SCHEPARTZ-SHRADER ALANNA S (US)
KRITZER JOSHUA A (US)
HART SCOTT A (US)
STEPHENS OLEN M (US)
SCHEPARTZ-SHRADER ALANNA S (US)
KRITZER JOSHUA A (US)
HART SCOTT A (US)
STEPHENS OLEN M (US)
International Classes:
C07C237/22; A61K31/16; A61K31/165; A61K31/40; A61K38/16; A61P31/18; A61P35/00; C07C237/24; C07D209/20; C07K14/005; C12N5/07; C12N5/071; A61K38/00
Domestic Patent References:
| WO1997047593A2 | 1997-12-18 |
Other References:
HART, SCOTT A. ET AL: "Helix Macrodipole Control of . beta .3- Peptide 14-Helix Stability in Water", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY , 125(14), 4022-4023 CODEN: JACSAT; ISSN: 0002-7863, 2003, XP002397194
ARVIDSSON, PER I. ET AL: "Design, machine synthesis, and NMR-solution structure of a .beta.-heptapeptide forming a salt-bridge stabilized 314-helix in methanol and in water", CHEMICAL COMMUNICATIONS (CAMBRIDGE, UNITED KINGDOM), (7), 649 -650 CODEN: CHCOFS; ISSN: 1359-7345, 2001, XP002397195
CHENG, RICHARD P. ET AL: "De Novo Design of a Monomeric Helical .beta.-Peptide Stabilized by Electrostatic Interactions", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 123(21), 5162 -5163 CODEN: JACSAT; ISSN: 0002-7863, 2001, XP002397196
RAGUSE, TAMI L. ET AL: "Environment-Independent 14-Helix Formation in Short .beta.-Peptides: Striking a Balance between Shape Control and Functional Diversity", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY , 125(19), 5592 5593 CODEN: JACSAT; ISSN: 0002-7863, 2003, XP002397197
GADEMANN, KARL ET AL: "Peptide folding induces high and selective affinity of a linear and small .beta.-peptide to the human somatostatin receptor 4", JOURNAL OF MEDICINAL CHEMISTRY , 44(15), 2460 -2468 CODEN: JMCMAR; ISSN: 0022-2623, 2001, XP002397198
GELLMAN ET AL: "FOLDAMERS A MANIFESTO", ACCOUNTS OF CHEMICAL RESEARCH, ACS, WASHINGTON, DC, US, vol. 31, no. 4, 1998, pages 173 - 180, XP002148555, ISSN: 0001-4842
KRITZER, JOSHUA A. ET AL: "Helical . beta .- Peptide Inhibitors of the p53-hDM2 Interaction", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY , 126(31), 9468-9469 CODEN: JACSAT; ISSN: 0002-7863, 2004, XP002397199
KRITZER, JOSHUA A. ET AL: ". beta .- Peptides as inhibitors of protein-protein interactions", BIOORGANIC & MEDICINAL CHEMISTRY , VOLUME DATE 2005, 13(1), 11-16 CODEN: BMECEP; ISSN: 0968-0896, 2004, XP002397200
KRITZER, JOSHUA A. ET AL: "A Rapid Library Screen for Tailoring . beta .- Peptide Structure and Function", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY , 127(42), 14584-14585 CODEN: JACSAT; ISSN: 0002-7863, 2005, XP002397201
KRITZER, JOSHUA A. ET AL: "Relationship between Side Chain Structure and 14-Helix Stability of . beta .3- Peptides in Water", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY , 127(1), 167-178 CODEN: JACSAT; ISSN: 0002-7863, 2005, XP002397202
MURRAY, JUSTIN K. ET AL: "Application of Microwave Irradiation to the Synthesis of 14-Helical .beta.-Peptides", ORGANIC LETTERS , 7(8), 1517-1520 CODEN: ORLEF7; ISSN: 1523-7060, 2005, XP002397203
ARVIDSSON, PER I. ET AL: "Design, machine synthesis, and NMR-solution structure of a .beta.-heptapeptide forming a salt-bridge stabilized 314-helix in methanol and in water", CHEMICAL COMMUNICATIONS (CAMBRIDGE, UNITED KINGDOM), (7), 649 -650 CODEN: CHCOFS; ISSN: 1359-7345, 2001, XP002397195
CHENG, RICHARD P. ET AL: "De Novo Design of a Monomeric Helical .beta.-Peptide Stabilized by Electrostatic Interactions", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 123(21), 5162 -5163 CODEN: JACSAT; ISSN: 0002-7863, 2001, XP002397196
RAGUSE, TAMI L. ET AL: "Environment-Independent 14-Helix Formation in Short .beta.-Peptides: Striking a Balance between Shape Control and Functional Diversity", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY , 125(19), 5592 5593 CODEN: JACSAT; ISSN: 0002-7863, 2003, XP002397197
GADEMANN, KARL ET AL: "Peptide folding induces high and selective affinity of a linear and small .beta.-peptide to the human somatostatin receptor 4", JOURNAL OF MEDICINAL CHEMISTRY , 44(15), 2460 -2468 CODEN: JMCMAR; ISSN: 0022-2623, 2001, XP002397198
GELLMAN ET AL: "FOLDAMERS A MANIFESTO", ACCOUNTS OF CHEMICAL RESEARCH, ACS, WASHINGTON, DC, US, vol. 31, no. 4, 1998, pages 173 - 180, XP002148555, ISSN: 0001-4842
KRITZER, JOSHUA A. ET AL: "Helical . beta .- Peptide Inhibitors of the p53-hDM2 Interaction", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY , 126(31), 9468-9469 CODEN: JACSAT; ISSN: 0002-7863, 2004, XP002397199
KRITZER, JOSHUA A. ET AL: ". beta .- Peptides as inhibitors of protein-protein interactions", BIOORGANIC & MEDICINAL CHEMISTRY , VOLUME DATE 2005, 13(1), 11-16 CODEN: BMECEP; ISSN: 0968-0896, 2004, XP002397200
KRITZER, JOSHUA A. ET AL: "A Rapid Library Screen for Tailoring . beta .- Peptide Structure and Function", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY , 127(42), 14584-14585 CODEN: JACSAT; ISSN: 0002-7863, 2005, XP002397201
KRITZER, JOSHUA A. ET AL: "Relationship between Side Chain Structure and 14-Helix Stability of . beta .3- Peptides in Water", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY , 127(1), 167-178 CODEN: JACSAT; ISSN: 0002-7863, 2005, XP002397202
MURRAY, JUSTIN K. ET AL: "Application of Microwave Irradiation to the Synthesis of 14-Helical .beta.-Peptides", ORGANIC LETTERS , 7(8), 1517-1520 CODEN: ORLEF7; ISSN: 1523-7060, 2005, XP002397203
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