BIARYL DERIVATIVES - SUMITOMO PHARMA

Title:

BIARYL DERIVATIVES

Document Type and Number:

WIPO Patent Application WO/2004/007439

Kind Code:

A1

Abstract:

A compound represented by the following general formula or its salt has an agonistic activity to peroxisome proliferator activated receptor &dgr (PPAR&dgr ) and, therefore, is useful as an agent elevating blood high density lipoprotein (HDL) level, a remedy for hypo-HDL cholesterolemia and/or a remedy for arteriosclerosis: (1) wherein R¹, R², R³, R⁴, R⁵, R⁶, R⁷ and R⁸ represent each hydrogen, hydroxy, optionally substituted C_1-6 alkyl, etc.; R⁹ and R¹⁰ represent each hydrogen or optionally substituted C_1-6 alkyl; R¹¹ and R¹² represent each hydrogen, fluorine, optionally substituted C_1-6 alkyl, etc.; W¹ and W² represent each oxygen, sulfur, etc.; A represents CH, a group represented by the formula:CR³ or nitrogen; and R¹³ represents carboxy, optionally substituted C_2-7 alkoxycarbonyl, etc.

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Inventors:

MIYAUCHI HIROSHI (JP)
UCHIYAMA KATSUYA (JP)
BAN HITOSHI (JP)
MORISHITA KOJI (JP)
MURAOKA MASAMI (JP)

Application Number:

PCT/JP2003/008683

Publication Date:

January 22, 2004

Filing Date:

July 08, 2003

Export Citation:

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Assignee:

SUMITOMO PHARMA (JP)
MIYAUCHI HIROSHI (JP)
UCHIYAMA KATSUYA (JP)
BAN HITOSHI (JP)
MORISHITA KOJI (JP)
MURAOKA MASAMI (JP)

International Classes:

A61K31/165; A61K31/192; A61K31/216; A61K31/341; A61K31/381; A61K31/40; A61K31/41; A61K31/4164; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/4453; A61K31/495; A61K31/5375; A61P3/06; A61P9/10; A61P43/00; C07C59/68; C07C229/18; C07C323/20; C07D213/40; C07D233/54; C07D233/64; C07D257/04; C07D295/185; C07D307/14; C07D333/20; (IPC1-7): C07C323/20; A61K31/165; A61K31/192; A61K31/216; A61K31/341; A61K31/381; A61K31/40; A61K31/41; A61K31/4164; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/4453; A61K31/495; A61K31/5375; A61P3/06; A61P9/10; A61P43/00; C07C59/135; C07C229/18; C07D213/40; C07D233/64; C07D257/04; C07D295/18; C07D307/52; C07D333/20

Domestic Patent References:

WO2000064876A1	2000-11-02
WO2000064888A1	2000-11-02

Attorney, Agent or Firm:

Isobe, Yutaka c/o Intellectual Property Department (Sumitomo Pharmaceuticals CO. LTD., 1-98, Kasugadenaka 3-chome, Konohana-k, Osaka-shi Osaka, JP)

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