BIARYL SUBSTITUTED THIAZOLES, OXAZOLES AND IMIDAZOLES AS SODIUM CHANNEL BLOCKERS

WIPO Patent Application WO2004094395

A3

Biaryl substituted thiazole, oxazole and imidazole compounds are sodium channel blockers useful for the treatment of pain. Pharmaceutical compositions comprise an effective amount of the instant compounds, either alone, or in combination with one or more therapeutically active compounds, and a pharmaceutically acceptable carrier. Methods of treatment or prevention of conditions, including acute pain, chronic pain, visceral pain, inflammatory pain, and neuropathic pain comprise administering an effective amount of the present compounds, either alone, or in combination with one or more therapeutically active compounds.

CHAKRAVARTY PRASUN K (US)
FISHER MICHAEL H (US)
PARSONS WILLIAM H (US)
TYAGARAJAN SRIRAM (US)
ZHOU BISHAN (US)

PCT/US2004/011271

February 24, 2005

April 14, 2004

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MERCK & CO INC (US)
CHAKRAVARTY PRASUN K (US)
FISHER MICHAEL H (US)
PARSONS WILLIAM H (US)
TYAGARAJAN SRIRAM (US)
ZHOU BISHAN (US)

C07D233/54; C07D233/68; C07D233/90; C07D263/32; C07D263/34; C07D263/48; C07D277/22; C07D277/24; C07D277/30; C07D277/40; C07D277/42; C07D277/46; C07D277/48; C07D277/52; C07D277/56; C07D403/04; C07D417/04; C07D417/12; C07D417/14; (IPC1-7): C07D277/42; C07D277/56

DATABASE CAPLUS [online] 12 May 1984 (1984-05-12), DANG NHU TAI ET AL: "Azomethine bases and their derivatives. VI. Synthesis of some azomethine bases and 4-thiazolidinones containing both thiophene and thiazole rings", XP002903566, accession no. STN Database accession no. 1983:470610
See also references of EP 1618099A4

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