PROCESS FOR THE PREPARATION OF VALSARTAN AND INTERMEDIATES THEREOF

Title:

PROCESS FOR THE PREPARATION OF VALSARTAN AND INTERMEDIATES THEREOF

Document Type and Number:

WIPO Patent Application WO2004094391

Kind Code:

A3

Abstract:

Provided are process for the preparation of valsartan and the precursors thereof and processes for preparing Valsartan containing less than about 5000 ppm residual solvent.

Inventors:

HAREL ZVI (IL)
RUKHMAN IGOR (IL)
DOLITZKY BEN-ZION (IL)
FLYAKS EVGENI (IL)
KOLTAI TAMAS (IL)
ARONHIME JUDITH (IL)

Application Number:

PCT/US2004/012316

Publication Date:

March 24, 2005

Filing Date:

April 21, 2004

Export Citation:

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Assignee:

TEVA PHARMA (US)
TEVA PHARMA (US)
HAREL ZVI (IL)
RUKHMAN IGOR (IL)
DOLITZKY BEN-ZION (IL)
FLYAKS EVGENI (IL)
KOLTAI TAMAS (IL)
ARONHIME JUDITH (IL)

International Classes:

A61K31/41; C07D257/04; (IPC1-7): C07D257/04

Domestic Patent References:

WO2003089417A1	2003-10-30
WO2004026847A1	2004-04-01
WO2004094392A1	2004-11-04

Foreign References:

US5399578A	1995-03-21
EP0570091A1	1993-11-18

Other References:

BUEHLMAYER P ET AL: "VALSARTAN, A POTENT, ORALLY ACTIVE ANGIOTENSIN II ANTAGONIST DEVELOPED FROM THE STRUCTURALLY NEW AMINO ACID SERIES", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 4, no. 1, 1994, pages 29 - 34, XP002065916, ISSN: 0960-894X
MOENIUS T ET AL: "Carbon-14 Labelling of DIOVAN in its Valine-Moiety", JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS, SUSSEX, GB, vol. 43, 2000, pages 1245 - 1252, XP002292105, ISSN: 0362-4803

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