Title:
BICYCLIC DERIVATIVE PARP INHIBITOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/227052
Kind Code:
A1
Abstract:
Disclosed herein are a compound represented by formula (II) or a stereoisomer, a pharmaceutically acceptable salt, a solvate, a co-crystal or a deuterated form thereof, or a pharmaceutical composition comprising same, and use thereof as a PARP-1 inhibitor in preparing a medicament for treating a related disease. Groups in formula (II) are defined in the description.
Inventors:
LI YAO (CN)
CHEN LEI (CN)
ZHANG HAOLIANG (CN)
KANG PENG (CN)
FU CHAO (CN)
GUI NAICHENG (CN)
TANG PINGMING (CN)
ZHANG CHEN (CN)
YAN PANGKE (CN)
CHEN LEI (CN)
ZHANG HAOLIANG (CN)
KANG PENG (CN)
FU CHAO (CN)
GUI NAICHENG (CN)
TANG PINGMING (CN)
ZHANG CHEN (CN)
YAN PANGKE (CN)
Application Number:
PCT/CN2023/096215
Publication Date:
November 30, 2023
Filing Date:
May 25, 2023
Export Citation:
Assignee:
TIBET HAISCO PHARMACEUTICAL CO LTD (CN)
International Classes:
C07D471/04; A61K31/4709; A61K31/496; A61K31/498; A61P35/00; C07D401/12; C07D401/14; C07D519/00
Domestic Patent References:
| WO2021260092A1 | 2021-12-30 | |||
| WO2022074617A1 | 2022-04-14 | |||
| WO2022222921A1 | 2022-10-27 | |||
| WO2022228387A1 | 2022-11-03 | |||
| WO2022261777A1 | 2022-12-22 | |||
| WO2023046034A1 | 2023-03-30 | |||
| WO2023046158A1 | 2023-03-30 | |||
| WO2023056039A1 | 2023-04-06 | |||
| WO2023088408A1 | 2023-05-25 | |||
| WO2023118085A1 | 2023-06-29 | |||
| WO2023134647A1 | 2023-07-20 | |||
| WO2023138541A1 | 2023-07-27 | |||
| WO2023146957A1 | 2023-08-03 |
Foreign References:
| CN114144413A | 2022-03-04 | |||
| US20100222348A1 | 2010-09-02 |
Other References:
JOHANNES JEFFREY W., BALAZS AMBER, BARRATT DEREK, BISTA MICHAL, CHUBA MATTHEW D., COSULICH SABINA, CRITCHLOW SUSAN E., DEGORCE SÉB: "Discovery of 5-{4-[(7-Ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)methyl]piperazin-1-yl}- N -methylpyridine-2-carboxamide (AZD5305): A PARP1–DNA Trapper with High Selectivity for PARP1 over PARP2 and Other PARPs", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 64, no. 19, 14 October 2021 (2021-10-14), US , pages 14498 - 14512, XP093028792, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.1c01012
Attorney, Agent or Firm:
BEIJING SANYOU INTELLECTUAL PROPERTY AGENCY LTD. (CN)
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