BICYCLIC HETEROCYCLIC DERIVATIVE HAVING VIRAL GROWTH INHIBITORY ACTIVITY AND PHARMACEUTICAL COMPOSITION CONTAINING SAME

Title:

BICYCLIC HETEROCYCLIC DERIVATIVE HAVING VIRAL GROWTH INHIBITORY ACTIVITY AND PHARMACEUTICAL COMPOSITION CONTAINING SAME

Document Type and Number:

WIPO Patent Application WO/2023/042879

Kind Code:

A1

Abstract:

The present invention provides: a compound having coronavirus 3CL protease inhibitory activity or a pharmaceutically acceptable salt thereof; and a pharmaceutical composition containing same. Provided is a compound represented by formula (I) (in the formula, each of carbon atom a and carbon atom b is a carbon atom constituting ring A, ring A is a substituted aromatic carbon ring or the like, R1 is a substituted or unsubstituted aromatic heterocyclic group or the like, R2 is a substituted or unsubstituted 6-membered aromatic carbon ring group or the like, m is 1 or the like, R5a is each independently a hydrogen atom or the like, R5b is each independently a hydrogen atom or the like, n is 1 or the like, R4a is a hydrogen atom or the like, and R4b is a hydrogen atom or the like), or a pharmaceutically acceptable salt thereof.

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Inventors:

TAODA YOSHIYUKI (JP)
UEHARA SHOTA (JP)
SAKO YUSUKE (JP)
HIRAI KEIICHIRO (JP)

Application Number:

PCT/JP2022/034552

Publication Date:

March 23, 2023

Filing Date:

September 15, 2022

Export Citation:

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Assignee:

SHIONOGI & CO (JP)
UNIV HOKKAIDO NAT UNIV CORP (JP)

International Classes:

C07D401/04; A61K31/517; A61K31/519; A61K31/5377; A61K31/541; A61P31/12; A61P31/14; A61P43/00; C07D401/06; C07D401/14; C07D403/06; C07D403/14; C07D405/04; C07D405/14; C07D409/14; C07D413/14; C07D417/14; C07D451/04; C07D471/04; C07D471/10; C07D487/04; C07D487/08; C07D487/10; C07D491/048; C07D491/107; C07D495/04; C07D498/04; C07D498/08; C07D519/00; C07K14/165; C12N15/50

Domestic Patent References:

WO2019185117A1	2019-10-03
WO1994019342A1	1994-09-01

Foreign References:

JP2009500405A	2009-01-08
JP2020519567A	2020-07-02
KR20080004304A	2008-01-09
JPH07504676A	1995-05-25
JP2000119272A	2000-04-25

Attorney, Agent or Firm:

SUGITA Ken-ichi et al. (JP)

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