Title:
BICYCLIC IMIDAZO-3-YL-AMINE DERIVATIVES WHICH ARE SUBSTITUTED ON THE SIXTH RING
Document Type and Number:
WIPO Patent Application WO2001027110
Kind Code:
A3
Abstract:
The invention relates to bicyclic imidazo-3-yl-amines of general formula (I) which are provided in the form of bases or of pharmaceutically acceptable salts thereof. The invention also relates to methods for producing the bicyclic imidazo-3-yl-amines and to medicaments containing, as an active ingredient, at least one bicyclic imidazo-3-yl-amine of general formula (I) provided in the form of the base or of a pharmaceutically acceptable salt.
More Like This:
Inventors:
GERLACH MATTHIAS (DE)
MAUL CORINNA (DE)
MAUL CORINNA (DE)
Application Number:
PCT/EP2000/009095
Publication Date:
September 20, 2001
Filing Date:
September 18, 2000
Export Citation:
Assignee:
GRUENENTHAL GMBH (DE)
GERLACH MATTHIAS (DE)
MAUL CORINNA (DE)
GERLACH MATTHIAS (DE)
MAUL CORINNA (DE)
International Classes:
A61K31/435; A61K31/437; A61K31/4745; A61K31/519; A61K31/53; A61K48/00; A61P25/04; A61P43/00; B29D30/52; C07D471/04; C07D487/04; C07D513/04; C07D487/00; C07F9/6561; G11C29/00; C07B61/00; (IPC1-7): C07D487/04; A61K31/435; A61K31/495; A61K31/505; A61K31/53; A61P25/00; A61P43/00
Foreign References:
| EP0822194A1 | 1998-02-04 | |||
| EP0266890A1 | 1988-05-11 | |||
| EP0518033A1 | 1992-12-16 |
Other References:
RIMOLI MG AVALLONE L DE CAPRARIIS P LURASCHI E ABIGNENTE E FILIPPELLI W BERRINO L ROSSI F: "Research on heterocyclic compounds. XXXVII. Synthesis and antiinflammatory activity of methyl-substituted imidazo[1,2-a]pyrazine derivatives", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY.CHIMICA THERAPEUTICA,FR,EDITIONS SCIENTIFIQUE ELSEVIER, PARIS, vol. 32, no. 3, 1997, pages 195 - 203, XP004075421, ISSN: 0223-5234
LANERI S ET AL: "Research on heterocyclic compounds - Part XXXIX. 2-Methylimidazo[1,2-a]pyrimidine-3-carboxylic derivatives: Synthesis and antiinflammatory activity", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY.CHIMICA THERAPEUTICA,FR,EDITIONS SCIENTIFIQUE ELSEVIER, PARIS, vol. 33, no. 3, 1 March 1998 (1998-03-01), pages 163 - 170, XP004122908, ISSN: 0223-5234
SAACHI A LANERI S ARENA F LURASCHI E ABIGNENTE E D'AMICO M BERRINO L ROSSI F: "Research on heterocyclic compounds. Part XXXVI. Imidazo[1,2-a]pyrimidine-2-acetic derivatives: synthesis and antiinflammatory activity", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY.CHIMICA THERAPEUTICA,FR,EDITIONS SCIENTIFIQUE ELSEVIER, PARIS, vol. 32, no. 7-8, 1 July 1997 (1997-07-01), pages 677 - 682, XP004088416, ISSN: 0223-5234
BLACKBURN C ET AL: "Parallel Synthesis of 3-Aminoimidazo[1,2-a]pyridines and pyrazines by a New Three-Component Condensation", TETRAHEDRON LETTERS,NL,ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, vol. 39, no. 22, 28 May 1998 (1998-05-28), pages 3635 - 3638, XP004118699, ISSN: 0040-4039
BLACKBURN C: "A Three-Component Solid-Phase Synthesis of 3-Aminoimidazo[1,2-a]azines", TETRAHEDRON LETTERS,NL,ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, vol. 39, no. 31, 30 July 1998 (1998-07-30), pages 5469 - 5472, XP004124091, ISSN: 0040-4039
H.BIENAYME ET AL.: "A New Heterocyclic Multicomponent Reaction for the Combinatorial Synthesis of Fused 3-Aminoimidazoles.", ANGEW. CHEM. INT. EDN., vol. 37, no. 16, 1998, pages 2234 - 2237, XP000978871
LANERI S ET AL: "Research on heterocyclic compounds - Part XXXIX. 2-Methylimidazo[1,2-a]pyrimidine-3-carboxylic derivatives: Synthesis and antiinflammatory activity", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY.CHIMICA THERAPEUTICA,FR,EDITIONS SCIENTIFIQUE ELSEVIER, PARIS, vol. 33, no. 3, 1 March 1998 (1998-03-01), pages 163 - 170, XP004122908, ISSN: 0223-5234
SAACHI A LANERI S ARENA F LURASCHI E ABIGNENTE E D'AMICO M BERRINO L ROSSI F: "Research on heterocyclic compounds. Part XXXVI. Imidazo[1,2-a]pyrimidine-2-acetic derivatives: synthesis and antiinflammatory activity", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY.CHIMICA THERAPEUTICA,FR,EDITIONS SCIENTIFIQUE ELSEVIER, PARIS, vol. 32, no. 7-8, 1 July 1997 (1997-07-01), pages 677 - 682, XP004088416, ISSN: 0223-5234
BLACKBURN C ET AL: "Parallel Synthesis of 3-Aminoimidazo[1,2-a]pyridines and pyrazines by a New Three-Component Condensation", TETRAHEDRON LETTERS,NL,ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, vol. 39, no. 22, 28 May 1998 (1998-05-28), pages 3635 - 3638, XP004118699, ISSN: 0040-4039
BLACKBURN C: "A Three-Component Solid-Phase Synthesis of 3-Aminoimidazo[1,2-a]azines", TETRAHEDRON LETTERS,NL,ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, vol. 39, no. 31, 30 July 1998 (1998-07-30), pages 5469 - 5472, XP004124091, ISSN: 0040-4039
H.BIENAYME ET AL.: "A New Heterocyclic Multicomponent Reaction for the Combinatorial Synthesis of Fused 3-Aminoimidazoles.", ANGEW. CHEM. INT. EDN., vol. 37, no. 16, 1998, pages 2234 - 2237, XP000978871
Download PDF:
Previous Patent: TERT.-BUTYL-(7-METHYL-IMIDAZO[1,2-A]PYRIDINE-3-YL)-AMINE DERIVATIVES
Next Patent: BICYCLIC IMIDAZO-3-YL-AMINE DERIVATIVES
Next Patent: BICYCLIC IMIDAZO-3-YL-AMINE DERIVATIVES