Title:
TERT.-BUTYL-(7-METHYL-IMIDAZO[1,2-A]PYRIDINE-3-YL)-AMINE DERIVATIVES
Document Type and Number:
WIPO Patent Application WO2001027109
Kind Code:
A3
Abstract:
The invention relates to tert.-butyl-(7-methyl-imidazo[1,2-a]pyridine-3-yl)-amine derivatives of the general structure (I), to a method for the preparation thereof and to medicaments that contain said compounds. The invention further relates to the use of the inventive tert.-butyl-(7-methyl-imidazo[1,2-a]pyridine-3-yl)-amine derivatives in the production of a medicament for the inhibition of the NO synthase and for the treatment of inter alia migraine and to pharmaceutical compositions that contain tert.-butyl-(7-methyl-imidazo[1,2-a]pyridine-3-yl)-amine derivatives.
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Inventors:
MAUL CORINNA (DE)
SUNDERMANN BERND (DE)
HENNIES HAGEN-HEINRICH (DE)
SCHNEIDER JOHANNES (DE)
GERLACH MATTHIAS (DE)
SUNDERMANN BERND (DE)
HENNIES HAGEN-HEINRICH (DE)
SCHNEIDER JOHANNES (DE)
GERLACH MATTHIAS (DE)
Application Number:
PCT/EP2000/009791
Publication Date:
September 20, 2001
Filing Date:
October 06, 2000
Export Citation:
Assignee:
GRUENENTHAL GMBH (DE)
MAUL CORINNA (DE)
SUNDERMANN BERND (DE)
HENNIES HAGEN HEINRICH (DE)
SCHNEIDER JOHANNES (DE)
GERLACH MATTHIAS (DE)
MAUL CORINNA (DE)
SUNDERMANN BERND (DE)
HENNIES HAGEN HEINRICH (DE)
SCHNEIDER JOHANNES (DE)
GERLACH MATTHIAS (DE)
International Classes:
A61K31/435; A61K31/437; A61P3/10; A61P9/10; C07D471/00; A61P17/02; A61P25/00; A61P25/14; A61P25/16; A61P25/28; A61P29/00; A61P31/04; A61P43/00; C07D471/04; C07D487/04; C07D513/04; C07F9/6561; C07B61/00; (IPC1-7): C07D471/04; A61K31/435; A61P25/00; A61P43/00
Foreign References:
| EP0266890A1 | 1988-05-11 | |||
| US3489755A | 1970-01-13 | |||
| US4450164A | 1984-05-22 | |||
| FR2638161A1 | 1990-04-27 |
Other References:
H.BIENAYMÉ ET AL.: "A New Heterocyclic Multicomponent Reaction for the Combinatorial Synthesis of Fused 3-Aminoimidazoles.", ANGEWANDTE CHEMIE INTERNATIONAL EDITION, vol. 37, no. 16, 1998, pages 2234 - 7, XP000978871
BLACKBURN C ET AL: "Parallel Synthesis of 3-Aminoimidazo[1,2-a]pyridines and pyrazines by a New Three-Component Condensation", TETRAHEDRON LETTERS,NL,ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, vol. 39, no. 22, 28 May 1998 (1998-05-28), pages 3635 - 3638, XP004118699, ISSN: 0040-4039
BLACKBURN C: "A Three-Component Solid-Phase Synthesis of 3-Aminoimidazo[1,2-a]azines", TETRAHEDRON LETTERS,NL,ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, vol. 39, no. 31, 30 July 1998 (1998-07-30), pages 5469 - 5472, XP004124091, ISSN: 0040-4039
F.MURAD: "Discovery of Some of the Biological Effetcs of Nitric Oxide and Its Role in Cell Signalling (Nobel Lecture)", ANGEWANDTE CHEMIE, INTERNATIONAL EDITION, vol. 38, 1999, pages 1156 - 68, XP002159759
BLACKBURN C ET AL: "Parallel Synthesis of 3-Aminoimidazo[1,2-a]pyridines and pyrazines by a New Three-Component Condensation", TETRAHEDRON LETTERS,NL,ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, vol. 39, no. 22, 28 May 1998 (1998-05-28), pages 3635 - 3638, XP004118699, ISSN: 0040-4039
BLACKBURN C: "A Three-Component Solid-Phase Synthesis of 3-Aminoimidazo[1,2-a]azines", TETRAHEDRON LETTERS,NL,ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, vol. 39, no. 31, 30 July 1998 (1998-07-30), pages 5469 - 5472, XP004124091, ISSN: 0040-4039
F.MURAD: "Discovery of Some of the Biological Effetcs of Nitric Oxide and Its Role in Cell Signalling (Nobel Lecture)", ANGEWANDTE CHEMIE, INTERNATIONAL EDITION, vol. 38, 1999, pages 1156 - 68, XP002159759
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