Title:
BIFIDOBACTERIUM BIFIDUM I771, SEPARATION AND PURIFICATION METHOD THEREFOR, AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/110281
Kind Code:
A1
Abstract:
The present invention pertains to the field of bioengineering, and discloses a Bifidobacterium bifidum i771, a separation and purification method therefor, and an application thereof. The bacterial strain is screened from infant feces, and is deposited in the China General Microbiological Culture Collection Center, with the deposit number of CGMCC NO. 19855. The Bifidobacterium bifidum i771 is obtained by enriching, screening, and continuously purifying a target bacterial strain in the feces of breast-feeding infants or young children. The bacterial strain obtained by the present invention can adjust the balance of gut microbiota, and treat or relieve clinical depression. At the same time, in the field of yogurt fermentation, the strain can also improve the aroma of fermented milk and enhance the preference degree of yogurt. The bacterium can be used to prepare fermented dairy products and applied as an active ingredient in a drug for treatment and/or relief of clinical depression.
Inventors:
ZHANG DONG (CN)
WEI LIHUA (CN)
YUAN QINGBIN (CN)
WANG SHIJIE (CN)
FENG LILI (CN)
XUE YULING (CN)
XUN YIPING (CN)
FENG XIAOYING (CN)
LIU YAOYAO (CN)
WEI LIHUA (CN)
YUAN QINGBIN (CN)
WANG SHIJIE (CN)
FENG LILI (CN)
XUE YULING (CN)
XUN YIPING (CN)
FENG XIAOYING (CN)
LIU YAOYAO (CN)
Application Number:
PCT/CN2020/134211
Publication Date:
June 02, 2022
Filing Date:
December 07, 2020
Export Citation:
Assignee:
JUNLEBAO DAIRY GROUP CO LTD (CN)
International Classes:
C12N1/20; A23C9/123; A23L33/135; A61K35/745; A61P25/24; C12N1/02; C12R1/01
Foreign References:
| CN111919890A | 2020-11-13 | |||
| CN111935985A | 2020-11-13 | |||
| CN111372596A | 2020-07-03 | |||
| CN111972497A | 2020-11-24 | |||
| CN110331119A | 2019-10-15 | |||
| CN107427539A | 2017-12-01 | |||
| CN110974917A | 2020-04-10 | |||
| CN111528283A | 2020-08-14 | |||
| CN106754524A | 2017-05-31 | |||
| CN111484957A | 2020-08-04 |
Other References:
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GOMI A., YAMAJI K., WATANABE O., YOSHIOKA M., MIYAZAKI K., IWAMA Y., URITA Y.: "Bifidobacterium bifidum YIT 10347 fermented milk exerts beneficial effects on gastrointestinal discomfort and symptoms in healthy adults: A double-blind, randomized, placebo-controlled study", JOURNAL OF DAIRY SCIENCE, vol. 101, no. 6, 1 June 2018 (2018-06-01), US , pages 4830 - 4841, XP055934190, ISSN: 0022-0302, DOI: 10.3168/jds.2017-13803
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HAGHIGHAT NEDA, RAJABI SHIRIN, MOHAMMADSHAHI MAJID: "Effect of synbiotic and probiotic supplementation on serum brain-derived neurotrophic factor level, depression and anxiety symptoms in hemodialysis patients: a randomized, double-blinded, clinical trial", NUTRITIONAL NEUROSCIENCE, vol. 24, no. 6, 3 June 2021 (2021-06-03), GB , pages 1 - 10, XP055934215, ISSN: 1028-415X, DOI: 10.1080/1028415X.2019.1646975
CULPEPPER, T.; CHRISTMAN, M.C.; NIEVES, C.; SPECHT, G.J.; ROWE, C.C.; SPAISER, S.J.; FORD, A.L.; DAHL, W.J.; GIRARD, S.A.; LANGKAM: "Bifidobacterium bifidum R0071 decreases stress-associated diarrhoea-related symptoms and self-reported stress: a secondary analysis of a randomised trial", BENEFICIAL MICROBES, vol. 7, no. 3, 1 June 2016 (2016-06-01), pages 327 - 336, XP009537037, ISSN: 1876-2883, DOI: 10.3920/BM2015.0156
SCHMIDT KRISTIN; COWEN PHILIP J.; HARMER CATHERINE J.; TZORTZIS GEORGE; ERRINGTON STEVEN; BURNET PHILIP W.: "Prebiotic intake reduces the waking cortisol response and alters emotional bias in healthy volunteers", PSYCHOPHARMACOLOGY, vol. 232, no. 10, 3 December 2014 (2014-12-03), DE , pages 1793 - 1801, XP035491859, ISSN: 0033-3158, DOI: 10.1007/s00213-014-3810-0
ADIKARI A M, MAHENDERAN APPUKUTTY , GARRY KUAN: "Psychotropic properties of probiotics : A systematic review ", INTERNATIONAL JOURNAL OF PUBLIC HEALTH AND CLINICAL SCIENCES, vol. 6, no. 4, 31 August 2019 (2019-08-31), pages 18 - 31, XP055934230, DOI: 10.32827/ijphes.6.4.18
GOMI A., YAMAJI K., WATANABE O., YOSHIOKA M., MIYAZAKI K., IWAMA Y., URITA Y.: "Bifidobacterium bifidum YIT 10347 fermented milk exerts beneficial effects on gastrointestinal discomfort and symptoms in healthy adults: A double-blind, randomized, placebo-controlled study", JOURNAL OF DAIRY SCIENCE, vol. 101, no. 6, 1 June 2018 (2018-06-01), US , pages 4830 - 4841, XP055934190, ISSN: 0022-0302, DOI: 10.3168/jds.2017-13803
LAURA STEENBERGEN, ROBERTA SELLARO, SASKIA VAN HEMERT, JOS A. BOSCH, LORENZA S. COLZATO: "A randomized controlled trial to test the effect of multispecies probiotics on cognitive reactivity to sad mood", BRAIN, vol. 48, 1 August 2015 (2015-08-01), US , pages 258 - 264, XP055226948, ISSN: 0889-1591, DOI: 10.1016/j.bbi.2015.04.003
HAGHIGHAT NEDA, RAJABI SHIRIN, MOHAMMADSHAHI MAJID: "Effect of synbiotic and probiotic supplementation on serum brain-derived neurotrophic factor level, depression and anxiety symptoms in hemodialysis patients: a randomized, double-blinded, clinical trial", NUTRITIONAL NEUROSCIENCE, vol. 24, no. 6, 3 June 2021 (2021-06-03), GB , pages 1 - 10, XP055934215, ISSN: 1028-415X, DOI: 10.1080/1028415X.2019.1646975
CULPEPPER, T.; CHRISTMAN, M.C.; NIEVES, C.; SPECHT, G.J.; ROWE, C.C.; SPAISER, S.J.; FORD, A.L.; DAHL, W.J.; GIRARD, S.A.; LANGKAM: "Bifidobacterium bifidum R0071 decreases stress-associated diarrhoea-related symptoms and self-reported stress: a secondary analysis of a randomised trial", BENEFICIAL MICROBES, vol. 7, no. 3, 1 June 2016 (2016-06-01), pages 327 - 336, XP009537037, ISSN: 1876-2883, DOI: 10.3920/BM2015.0156
SCHMIDT KRISTIN; COWEN PHILIP J.; HARMER CATHERINE J.; TZORTZIS GEORGE; ERRINGTON STEVEN; BURNET PHILIP W.: "Prebiotic intake reduces the waking cortisol response and alters emotional bias in healthy volunteers", PSYCHOPHARMACOLOGY, vol. 232, no. 10, 3 December 2014 (2014-12-03), DE , pages 1793 - 1801, XP035491859, ISSN: 0033-3158, DOI: 10.1007/s00213-014-3810-0
ADIKARI A M, MAHENDERAN APPUKUTTY , GARRY KUAN: "Psychotropic properties of probiotics : A systematic review ", INTERNATIONAL JOURNAL OF PUBLIC HEALTH AND CLINICAL SCIENCES, vol. 6, no. 4, 31 August 2019 (2019-08-31), pages 18 - 31, XP055934230, DOI: 10.32827/ijphes.6.4.18
Attorney, Agent or Firm:
SHIJIAZHUANG KECHENG PATENT OFFICE (GENERAL PARTNERSHIP) (CN)
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