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Title:
BIFLAVONOID-NICKEL COMPLEX AND PREPARATION METHOD AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/153334
Kind Code:
A1
Abstract:
The present invention provides a biflavonoid-nickel complex and a preparation method and application thereof. The present invention uses amentoflavone as a ligand and a nickel ion as a central ion for reaction to obtain an amentoflavone-nickel complex. The structure of the complex was characterized by infrared spectroscopy, ultraviolet-visible absorption spectroscopy, and high-resolution mass spectrometry. Moreover, antitumor and antioxidant activity of the amentoflavone-nickel complex were studied in the present invention. An MTT method shows that the amentoflavone-nickel complex has stronger antitumor activity than amentoflavone. Both a pyrogallol autoxidation method and an ABTS method show that the antioxidant activity of the amentoflavone-nickel complex is stronger than amentoflavone itself. The antitumor and antioxidant activity of amentoflavone are improved due to the formation of the biflavonoid-nickel complex, and the biflavonoid-nickel complex is expected to be used in drug development.

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Inventors:
CAO FULIANG (CN)
YANG SHILONG (CN)
XU LI (CN)
TANG YING (CN)
ZHOU MENGYI (CN)
LU WEN (CN)
ZHAO FENGYI (CN)
JIANG GUOBIN (CN)
Application Number:
PCT/CN2018/076752
Publication Date:
August 30, 2018
Filing Date:
February 13, 2018
Export Citation:
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Assignee:
UNIV NANJING FORESTRY (CN)
International Classes:
C07F15/04; A61P35/00; A61P39/06
Foreign References:
CN106892946A2017-06-27
CN101857583A2010-10-13
US20060024691A12006-02-02
Other References:
QAMAR UDDI N: "The Biflavonoid, Amentoflavone Degrades DNA in the Presence of Copper Ions", TOXICOLOGY IN VITRO, vol. 18, no. 4, 1 August 2004 (2004-08-01), pages 435 - 440, XP055532214
Attorney, Agent or Firm:
NANJING SHENYUN INTELLECTUAL PROPERTY OFFICE (GENERAL PARTNERSHIP) (CN)
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