Title:
A BIFUNCTIONAL AGGREGATION-INDUCED EMISSION LUMINOGEN FOR MONITORING AND KILLING OF MULTIDRUG-RESISTANT BACTERIA
Document Type and Number:
WIPO Patent Application WO/2020/011228
Kind Code:
A1
Abstract:
Antibiotic compounds having both antibiotic and aggregation-induced emission (AIE) characteristics. The compounds comprise an azole antibiotic unit, for example naphthalimide triazole (NT), and an AIE unit, for example triphenylethylene (TriPE). The compounds act as an effective AIEgen with ROS generating capabilities. The present combinations of an azole antibiotic unit and an AIE unit do not negatively affect the antibacterial properties of the azole. Accordingly, the present compounds exterminate bacteria with both the antibacterial mechanism of the azole along with the ROS produced when the AIE unit is exposed to light. In addition, the intrinsic imagining ability of the present compounds enables them to be used as imaging tools to monitor the drug-bacteria interaction. Collectively, the present compounds provide multiple functions including imaging, monitoring, and bacterial infection inhibition for integrated diagnosis and treatment in clinical practices.
Inventors:
TANG BENZHONG (CN)
LI YING (CN)
ZHAO ZHENG (CN)
LI YING (CN)
ZHAO ZHENG (CN)
Application Number:
PCT/CN2019/095581
Publication Date:
January 16, 2020
Filing Date:
July 11, 2019
Export Citation:
Assignee:
UNIV HONG KONG SCI & TECH (CN)
International Classes:
A61P31/04; C09K11/06; C07D221/06; C07D255/02; G01N21/64
Domestic Patent References:
| WO2016078603A1 | 2016-05-26 |
Foreign References:
| CN107602469A | 2018-01-19 | |||
| CN106461641A | 2017-02-22 | |||
| CN102706839A | 2012-10-03 |
Other References:
ZHANG Y.Y. ET AL.: "Synthesis and activities of naphthalimide azoles as a new type of antibacterial and antifungal agents", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 21, no. 14, 18 May 2011 (2011-05-18), pages 4349 - 4352, XP028234413, DOI: 10.1016/j.bmcl.2011.05.042
ZHANG G.F. ET AL.: "Utilising tetraphenylethene as a dual activator for intramolecular charge transfer and aggregation induced emission", CHEMICAL COMMUNICATIONS, vol. 48, no. 62, 31 December 2012 (2012-12-31), pages 7711 - 7713, XP055681927
ZHANG G.F. ET AL.: "Utilising tetraphenylethene as a dual activator for intramolecular charge transfer and aggregation induced emission", CHEMICAL COMMUNICATIONS, vol. 48, no. 62, 31 December 2012 (2012-12-31), pages 7711 - 7713, XP055681927
Attorney, Agent or Firm:
TEE&HOWE INTELLECTUAL PROPERTY ATTORNEYS (CN)
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