Title:
BIFUNCTIONAL FUSION PROTEIN TARGETING PD-L1 AND TGFβ, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/042715
Kind Code:
A1
Abstract:
The present invention provides a bifunctional fusion protein targeting programmed cell death ligand-1 (PD-L1) and transforming growth factor-β (TGFβ), and also provides a nucleic acid molecule encoding the fusion protein of the present invention, an expression vector for expressing the fusion protein of the present invention, a host cell, a method, and a pharmaceutical composition containing the fusion protein of the present invention. The present invention also provides a medical application of the bifunctional fusion protein targeting PD-L1 and TGFβ in the treatment of tumor diseases.
Inventors:
HE LIZHEN (CN)
YU PIN (CN)
ZHOU LIANG (CN)
YOU QIANG (CN)
GUO XUANCHENG (CN)
LU MINKAN (CN)
XU FEIHU (CN)
WANG TONGYING (CN)
SUN HANDONG (CN)
YU PIN (CN)
ZHOU LIANG (CN)
YOU QIANG (CN)
GUO XUANCHENG (CN)
LU MINKAN (CN)
XU FEIHU (CN)
WANG TONGYING (CN)
SUN HANDONG (CN)
Application Number:
PCT/CN2021/115231
Publication Date:
March 03, 2022
Filing Date:
August 30, 2021
Export Citation:
Assignee:
HANGZHOU JIUYUAN GENE ENG CO LTD (CN)
International Classes:
C07K19/00; A61K38/17; A61P35/00; C12N15/62
Domestic Patent References:
| WO2018205985A1 | 2018-11-15 | |||
| WO2020094122A1 | 2020-05-14 |
Foreign References:
| CN112480253A | 2021-03-12 | |||
| CN111848800A | 2020-10-30 | |||
| CN112745391A | 2021-05-04 | |||
| CN106103488A | 2016-11-09 |
Other References:
HU MENGXUE, XU BIN, YU JINMING, SONG QIBIN: "Advances of bifunctional anti-PD-L1/TGF-β fusion protein M7824", JOURNAL OF INTERNATIONAL ONCOLOGY, CHINESE MEDICAL ASSOCIATION; SHANDONG ACADEMY OF MEDICAL SCIENCES, CN, vol. 46, no. 5, 31 May 2019 (2019-05-31), CN , pages 281 - 284, XP009526488, ISSN: 1673-422X, DOI: 10.3760/cma.j.issn.1673-422X.2019.05.006
HANNE LIND, SOFIA R GAMEIRO, CAROLINE JOCHEMS, RENEE N. DONAHUE, JULIUS STRAUSS, JAMES L GULLEY, CLAUDIA PALENA, JEFFREY SCHLOM: "Dual targeting of TGF-β and PD-L1 via a bifunctional anti-PD-L1/TGF-βRII agent: status of preclinical and clinical advances", JOURNAL FOR IMMUNOTHERAPY OF CANCER, vol. 8, no. 1, 19 December 2019 (2019-12-19), pages e000433, XP055686662, DOI: 10.1136/jitc-2019-000433
HANNE LIND, SOFIA R GAMEIRO, CAROLINE JOCHEMS, RENEE N. DONAHUE, JULIUS STRAUSS, JAMES L GULLEY, CLAUDIA PALENA, JEFFREY SCHLOM: "Dual targeting of TGF-β and PD-L1 via a bifunctional anti-PD-L1/TGF-βRII agent: status of preclinical and clinical advances", JOURNAL FOR IMMUNOTHERAPY OF CANCER, vol. 8, no. 1, 19 December 2019 (2019-12-19), pages e000433, XP055686662, DOI: 10.1136/jitc-2019-000433
Attorney, Agent or Firm:
ZHEJIANG HANGZHOU JINTONG PATENT OFFICE CO., LTD (CN)
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