Title:
BIFUNCTIONAL MOLECULE FORMED BY FUSION OF PD1 ANTIBODY AND INTERLEUKIN 2
Document Type and Number:
WIPO Patent Application WO/2023/143308
Kind Code:
A1
Abstract:
The present invention relates to a bifunctional molecule formed by fusion of a PD1 antibody and interleukin 2. The bifunctional molecule comprises a heterodimer composed of a first monomer and a second monomer as follows: (1) a first monomer formed by linking interleukin 2 (IL2) to an immunoglobulin Fc single chain; and (2) a second monomer formed by linking an Fab/ScFv of an antibody against PD1 molecule on the surface of a T cell to an Fc single chain. The bifunctional molecule may also be a homodimer comprising a monomer comprising: (1) an interleukin 2 functional block; and (2) a monomer of an antibody or a monomer formed by linking an Fab/ScFv of an antibody to an Fc single chain, the antibody being an antibody against PD1 molecule on the surface of a T cell. The present invention further relates to use of the bifunctional molecule in preparing an anti-tumor medicament.
Inventors:
PENG HUA (CN)
CAO SHUAISHUAI (CN)
CAO SHUAISHUAI (CN)
Application Number:
PCT/CN2023/072903
Publication Date:
August 03, 2023
Filing Date:
January 18, 2023
Export Citation:
Assignee:
INST BIOPHYSICS CAS (CN)
International Classes:
A61K38/20; C07K19/00; A61K39/395; A61K45/06; A61K47/68; A61P35/00; C12N15/62
Domestic Patent References:
| WO2020259536A1 | 2020-12-30 |
Foreign References:
| CN114437228A | 2022-05-06 | |||
| CN110256583A | 2019-09-20 |
Attorney, Agent or Firm:
BEIJING CHENGHUI LAW FIRM (CN)
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